Localized Mastocytosis of the Vulva

Abstract

Mastocytosis is a relatively common disorder characterized by mast cell collections in the skin and other organ systems. Affected children are more likely than adults to have limited cutaneous disease. We report two patients with localized vulvar mastocytosis in the absence of other cutaneous findings and review previous reports of vulvar involvement in cutaneous mastocytosis.

Yellowish Nodules on the Vulva in a 6-year-old Girl: A Quiz

“…Symptoms of mastocytosis in children are due to mastcell degranulation and mediator release such as itch, palpitations, headache, episodic flushing, bronchospasm, diarrhoea or syncope, which can appear spontaneously or after mechanical, physical or chemical stimulation (4,10). However, most children with skin mastocytosis remain asymptomatic or have only minimal degranulation symptoms (10).…”