Localized Lymphomatoid Papulosis

Abstract

A 50-year-old Japanese male visited our clinic in April 1999 with a 2-year history of self-healing, reddish papules on his right palm. On examination, there were grouped erythematous papules, 2–4 mm in size, which formed a relatively well-circumscribed erythematous plaque. A biopsy specimen showed a wedge-shaped, dense dermal infiltrate consisting of variously sized mononuclear lymphoid cells mixed with few large CD30-positive cells and inflammatory cells, suggesting the diagnosis of regional lymphomatoid papulosis (LyP). Analysis of the T cell receptor gene revealed a polyclonal pattern on lesional skin. Only 5 cases of LyP presenting in a regional distribution have been reported previously. Although the etiology of localized LyP remains unknown, considering that 2 of 5 reported patients developed widespread lesions regional LyP may be the initial presentation of typical LyP.

EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma*

“…76,80,88,[91][92][93][94][95] CR was observed in 4 of 5 patients after 2-6 weeks of treatment with 3-15 MU IFN-␣ per week in an open trial. 94 Discontinuation resulted in relapses within 3-4 weeks and the necessity for maintenance therapy over 10-17 months.…”

“…Treatment with topical steroids has been documented in detail in 25 patients with CR observed in only 3 of 25 patients (12%). 63,72,[84][85][86][87][88][89][90] Topical steroids are often combined with other therapies, such as antibiotics or phototherapy. 72 In one study of children with LYP, with halobetasol or clobetasol propionate applied twice per day for 2 to 3 weeks followed by weekly pulsed application, complete resolution of all lesions occurred over 6 months, but 2 of the 3 children developed new lesions.…”

Persistent Agmination of Lymphomatoid Papulosis: An Ongoing Debate

“…The most commonly affected sites are the buttocks, flank, lower abdomen and legs. Furthermore, sporadic cases with an exclusive acral involvement have been reported [9,10]. Localized LyP tends to relapse on the same anatomical area, although in some instances the recurrence lasts some years [8].…”

Medicolegal issues in cluster headache

“…Electrocardiographic monitoring is recommended to reduce this risk. Another recently recognized risk of verapamil therapy is lymphomatoid papulosis, a condition that can progress to lymphoma if the drug is not stopped [28].…”