Localized K63 ubiquitin signaling is regulated by VCP/p97 during oxidative stress
Austin O. Maduka,
Sandhya Manohar,
Matthew W. Foster
et al.
Abstract:Under stress conditions, cells reprogram their molecular machineries to mitigate damage and promote survival. Ubiquitin signaling is globally increased during oxidative stress, controlling protein fate and supporting stress defenses at several subcellular compartments. However, the rules driving subcellular ubiquitin localization to promote these concerted response mechanisms remain understudied. Here, we show that K63-linked ubiquitin chains, known to promote proteasome-independent pathways, accumulate primar… Show more
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