Localized Juvenile Spongiotic Gingival Hyperplasia: Report of Two Cases

Kalogirou, Eleni‐Marina; Chatzidimitriou, Konstantina; Tosios, Konstantinos I.; Piperi, Evangelia; Sklavounou, Alexandra

doi:10.17796/1053-4628-41.3.228

Cited by 13 publications

(11 citation statements)

References 11 publications

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“…Similar to previous reports, the most commonly affected oral site for LJSGH was the anterior maxillary gingiva. The reason for this localization in the anterior maxilla is unknown.…”

Section: Discussionsupporting

confidence: 89%

“…The median age in our series was 13 years old. Together with the previous case series, we conclude that LJSGH is most common in but not limited to the juvenile age range.…”

Section: Discussionsupporting

confidence: 83%

“…In this current study, we found that all but three patients were less than 20 years of age, with 29.6% of the patients younger than 10 years old, and 44.4% of the patients between 11 and 15 years. The majority of patients within other prior publications are also between 11 and 15 years . Vargo et al reported a large age range between 3 and 64 years old, with the median to be 14.5 years old.…”

Section: Discussionmentioning

confidence: 95%

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Localized juvenile spongiotic gingival hyperplasia: A report of 27 cases

Wang

Jordan

2019

J Cutan Pathol

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Background: Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a poorly understood but distinctive inflammatory hyperplasia occurring in children and young adults. Fewer than 100 cases have been reported since its initial description.Methods: During the period of 2015 to 2018, cases of LJSGH were identified, retrieved and their clinical and histopathological data reviewed.Results: There were 27 cases, with a median age of 13 years (range 7-72 years).Twenty-four of 27 patients were less than 20 years old, and in three cases the patients were over 60 years of age. The most commonly affected site was the anterior maxillary gingiva presenting as a solitary, red, and papillated lesion. Typical microscopic findings included elevated areas of variably acanthotic, spongiotic nonkeratinized epithelium with elongated rete ridges, accompanied by a neutrophilic-rich infiltrate. An abrupt transition between epithelium affected by LJSGH and normal mucosa was characteristic.LJSGH typically exhibited full-thickness epithelial expression of CK19 without expression of estrogen and progesterone receptors. Conclusions:The clinical and histopathologic characteristics of LJSGH are unique and consistent. Despite the name, the condition is not limited to juveniles and can occur in adults. LJSGH in adults and juveniles shares the same spectrum of histopathologic and immunohistochemical findings. K E Y W O R D Sgingival lesion, gingivitis, inflammatory gingival hyperplasia, oral disease

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“…Similar to previous reports, the most commonly affected oral site for LJSGH was the anterior maxillary gingiva. The reason for this localization in the anterior maxilla is unknown.…”

Section: Discussionsupporting

confidence: 89%

“…The median age in our series was 13 years old. Together with the previous case series, we conclude that LJSGH is most common in but not limited to the juvenile age range.…”

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 95%

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Localized juvenile spongiotic gingival hyperplasia: A report of 27 cases

Wang

Jordan

2019

J Cutan Pathol

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“…[18][19][20] In our literature review, 221 previous reported cases of LJSGH were found with no clear gender preponderance (Table 1). [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] This number may be an overestimation or an underestimation, as the disease is recently described and the diagnostic criteria has not been well established in some reports. Some authors have suggested that the lesion should be named as localized spongiotic gingival hyperplasia, as the disease may occur in both pediatric and adult population.…”

Section: Discussionmentioning

confidence: 99%

“…Table 1 summarizes the previous reports of LJSGH. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] The main clinical feature of the disease consists of an erythematous line accompanying the marginal gingiva, and in some cases, gingival hyperplasia is present. Characteristically the disease is not associated with plaque-induced inflammation.…”

Section: Introductionmentioning

confidence: 99%

A Conservative Approach for Localized Spongiotic Gingivitis Hyperplasia Using Photodynamic Therapy: A Case Report and Review of the Literature

Vieira

Leite

Figueiredo

et al. 2019

Photobiomodulation, Photomedicine, and Laser Surgery

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Objective: To describe a clinical case of successful conservative management of Localized Juvenile Spongiotic Gingivitis Hyperplasia (LJSGH) using photodynamic therapy (PDT) and reviews the current literature on this pathology. Background data: LJSGH is a recently described rare disease with controversial treatment results. As of today, 13 publications report surgical treatment approaches. The use of CO 2 laser and cryotherapy was reported only in one study. The use of PDT was not previously reported. Patients and methods: A 9-year-old male patient was referred to our institution with the chief complaint of asymptomatic ''inflamed gingiva'' starting 1 year before. Clinical examination revealed an erythematous line accompanying the gingival contour, with a certain degree of hyperplasia. The diagnosis of LJSGH was performed based on clinical features and later confirmed histopathologically. A novel approach using PDT was then proposed. The photosensitizer was methylene blue, and a semiconductor laser diode was used. Results: One week after starting PDT, gingival hyperplasia was partially reduced. Immediately after the end of treatment, a significant reduction of gingival hyperplasia was observed. PDT proved to be safe, quick and painless, with no esthetic harm. Conclusions: This case illustrates the benefit of a more conservative approach as opposed to surgical procedure, with good clinical response and decreased morbidity over a 2-year follow-up period.

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Spongiotic Gingival Hyperplasia Synchronously Involving Multiple Sites: Case Report and Review of the Literature

Siamantas¹,

Kalogirou

Tosios³

et al. 2018

Head and Neck Pathol

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Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a gingival lesion with unique clinicopathologic features that may involve synchronously multiple sites. We present a case with lesions clinically consistent with LJSGH in four jaw quadrants, confirmed by biopsy and review the English literature on multifocal LJSGH cases. A 19 year-old woman presented with circumscribed, erythematous overgrowths on the right and left maxillary and mandibular gingiva. With the provisional diagnosis of multifocal LJSGH, total excision of four maxillary lesions was performed. Clinical, microscopic and immunohistochemical examination with cytokeratin 19 confirmed the diagnosis of LJSGH in multiple sites. The excised lesions showed partial to complete recurrence after 4 months, while spontaneous regression of all but one lesion was observed after 15 months. Twenty cases with synchronous involvement of the gingiva of at least two teeth were previously reported. Their clinical features were comparable to that of solitary LJSGH. Only one case involved all four jaw quadrants. Spontaneous remission has not been documented before. The recognition of multiple lesions with clinicopathologic features diagnostic of LJSGH in the same adult patient argue against the designations "localized" and "juvenile". Recurrences are common, while remission might occur.

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Localized Juvenile Spongiotic Gingival Hyperplasia: Report of Two Cases

Abstract: LJSGH is a recently introduced entity that is worth attention in the clinical pediatric dentistry. Clinical and histological examination is required for the final diagnosis, while immunohistochemistry has shed light to LJSGH pathogenesis.

Cited by 13 publications

References 11 publications

Localized juvenile spongiotic gingival hyperplasia: A report of 27 cases

Localized juvenile spongiotic gingival hyperplasia: A report of 27 cases

A Conservative Approach for Localized Spongiotic Gingivitis Hyperplasia Using Photodynamic Therapy: A Case Report and Review of the Literature

Spongiotic Gingival Hyperplasia Synchronously Involving Multiple Sites: Case Report and Review of the Literature

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