Localized juvenile spongiotic gingival hyperplasia possibly originates from the junctional gingival epithelium—an immunohistochemical study

Allon, Irit; Lammert, K.; Iwase, R.; Spears, Robert; Wright, John M.; Naidu, Aparna

doi:10.1111/his.12774

Cited by 26 publications

(47 citation statements)

References 12 publications

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“…However, immunohistochemical studies for the presence of estrogen and progesterone receptors have been negative . Additionally, the papillary architecture of the lesion raises the possibility of human papillomavirus (HPV) as an etiologic factor . However, LJSGH usually lacks the characteristic histopathologic features seen in HPV‐related lesions, particularly koilocytosis .…”

Section: Discussionmentioning

confidence: 99%

“…The age range of LJSGH also raises the possibility of a developmental etiology. Based on the histologic similarity of the LJSGH's epithelium to the junctional epithelium (JE) of the gingival sulcus, it was previously suggested that “exteriorization” of the JE could account for the development of this lesion . Junctional and marginal gingiva are phenotypically distinct.…”

Section: Discussionmentioning

confidence: 99%

“…Localized juvenile spongiotic gingival hyperplasia (LJSGH) is an unusual and distinct subtype of gingival inflammatory hyperplasia that usually affects the anterior facial gingiva in young patients, most commonly in the second decade of life . There seems to be a female predilection of about 2:1 . Clinically, it is generally characterized as a solitary, small lesion, with a micropapillary or granular surface and a bright red gingival overgrowth.…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, it is generally characterized as a solitary, small lesion, with a micropapillary or granular surface and a bright red gingival overgrowth. LJSGH is painless and may bleed easily during oral hygiene procedures . The attached gingiva of the anterior maxilla is the most common location, with variable marginal gingival involvement .…”

Section: Introductionmentioning

confidence: 99%

“…The pathogenesis of these lesions has remained unclear . Plaque‐induced inflammation is apparently not the cause as there is a lack of response to oral hygiene and the lesion does not regress after conventional periodontal treatment . Herein, the authors report four new cases of LJSGH, aiming to avoid diagnostic mistakes and overtreatment.…”

Section: Introductionmentioning

confidence: 99%

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Localized Juvenile Spongiotic Gingival Hyperplasia: A Report of Four Cases and Literature Review

Fernandes

Wright

Lopes

et al. 2018

Clin Adv Periodontics

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Introduction The aim of this case report is to present a distinct subtype of gingival inflammatory hyperplasia, providing information to avoid diagnostic mistakes and overtreatment. Also, an unexpected progression of the lesion is shown. Furthermore, a review of the literature to discuss the pathogenesis, diagnosis, treatment, and the need for new therapeutic approaches is presented. Case Series The authors report four cases of localized juvenile spongiotic gingival hyperplasia involving the anterior maxillary gingiva with distinct clinical features. The patients were followed for a period of 1 to 9 years, and the evolution of the lesions was documented. Surgical excision or therapy by topical steroids was used to treat the lesions. Conclusions The long‐term follow‐up provides important information for clinicians not to eliminate older patients for lesion diagnosis. Although surgical excision should not be recommended for all cases, considering the risk of esthetic problems, the treatment modality using topical steroids was not permanently effective in the authors’ cases. Investigations about new esthetic treatment modalities for lesions are needed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Localized Juvenile Spongiotic Gingival Hyperplasia: A Report of Four Cases and Literature Review

Fernandes

Wright

Lopes

et al. 2018

Clin Adv Periodontics

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Novel treatment approach of localized juvenile spongiotic gingival hyperplasia with use of Nd:YAG laser

Goldberg

Fatahzadeh

Bortnik

et al. 2023

Clin Adv Periodontics

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IntroductionThis article describes the management of two patients who presented with localized juvenile spongiotic gingival hyperplasia. This disease entity is poorly understood, and literature regarding successful treatment is scant. However, there are common themes to management including proper diagnosis and treatment via removal of the affected tissue. The biopsy demonstrates intercellular edema and neutrophil infiltrate with epithelial and connective tissue disease components, so surgical deepithelialization may not be adequate to definitively treat the disease.Methods and ResultsThis article presents two cases of the disease and suggests the use of the Nd:YAG laser as an alternative management modality.ConclusionTo our knowledge, we present the first cases of localized juvenile spongiotic gingival hyperplasia treated with the Nd:YAG laser.Key pointsWhy are these cases new information? To our knowledge, this case series illustrates the first use of an Nd:YAG laser to treat the rare pathology localized juvenile spongiotic gingival hyperplasia. What are the keys to successful management of these cases? To properly manage this rare presentation, proper diagnosis is paramount. Following diagnosis with microscopic evaluation, deepithelialization and treatment of underlying connective tissue infiltrate via the Nd:YAG laser offers an elegant option to treat the pathology and maintain esthetic outcomes. What are the primary limitations to success in these cases? The primary limitations of these cases include the small sample size, which is attributable to the rarity of the disease.

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Characterization of juvenile spongiotic gingival hyperplasia as an entity of odontogenic origin

Mendoza

Alberdi-Navarro

Marichalar-Mendía

et al. 2019

Journal of Periodontology

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Background Juvenile spongiotic gingival hyperplasia (JSGH) is a distinct clinicopathological entity of the buccal gingiva of young patients which has been related to several factors such as plaque formation, hormonal modifications, and viral infections; however, its true etiopathogenesis remains unsolved. Several immunohistochemical studies have demonstrated the similarity between the junctional epithelium (JE) and the hyperplasic epithelium of JSGH. The objective of this study is to analyze the clinicopathological and immunohistochemical characteristics of JSGH to explain its origin. Methods Clinicopathlogical data of 10 cases of JSGH (five men and five women) with a mean age of 13 years (range: 9 to 17 years) were collected. CK7, CK14, CK19, CD3, CD20, S100, and Ki‐67 antibodies were used for comparative immunohistochemical study. Results All the lesions showed hyperplasic epithelium in its central portion, exhibiting marked spongiosis, vascular proliferation, and a chronic inflammatory infiltrate on the subepithelial connective tissue. CK19 was positive in the whole hyperplasic epithelium of JSGH and the basal layer of the marginal gingiva, while expression of CK14 was present in all epithelial layers of both the JSGH and that of the marginal gingiva. The subepithelial inflammatory infiltrate has a larger amount of CD20 positive cells. Conclusion JSGH is a reactive tumor of the gingiva that may have an odontogenic etiology, whose origin seems to be the remnants of JE.

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Localized juvenile spongiotic gingival hyperplasia possibly originates from the junctional gingival epithelium—an immunohistochemical study

Cited by 26 publications

References 12 publications

Localized Juvenile Spongiotic Gingival Hyperplasia: A Report of Four Cases and Literature Review

Localized Juvenile Spongiotic Gingival Hyperplasia: A Report of Four Cases and Literature Review

Novel treatment approach of localized juvenile spongiotic gingival hyperplasia with use of Nd:YAG laser

Characterization of juvenile spongiotic gingival hyperplasia as an entity of odontogenic origin

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