Localized B0 shimming based on 23Na MRI at 7 T

Gast, Lena V.; Henning, A; Hensel, Bernhard; Uder, Michael; Nagel, Armin M.

doi:10.1002/mrm.28011

Cited by 11 publications

(3 citation statements)

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“…To reduce motion effects during the acquisition, several cushions were used to fix the position of the leg within the 23 Na/ 39 K RF coil. Before 23 Na/ 39 K MRI measurements, B 0 shimming was performed based on 23 Na MRI data in combination with a constrained regularized algorithm 24 . Quantitative 39 K and 23 Na MRI data were acquired using a 3D acquisition-weighted stack-of-stars (AW-SOSt) sequence applying a nonselective excitation pulse 25 .…”

Section: Methodsmentioning

confidence: 99%

“…Before 23 Na/ 39 K MRI measurements, B 0 shimming was performed based on 23 Na MRI data in combination with a constrained regularized algorithm. 24 Quantitative 39 K and 23 Na MRI data were acquired using a 3D acquisition-weighted stack-of-stars (AW-SOSt) sequence applying a nonselective excitation pulse. 25 Most relevant MRI measurement parameters are summarized in Table 1.…”

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confidence: 99%

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MRI of Potassium and Sodium Enables Comprehensive Analysis of Ion Perturbations in Skeletal Muscle Tissue After Eccentric Exercise

et al. 2022

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Objectives: The aims were to investigate if potassium ( 39 K) magnetic resonance imaging (MRI) can be used to analyze changes in the apparent tissue potassium concentration (aTPC) in calf muscle tissue after eccentric exercise and in delayed-onset muscle soreness, and to compare these to corresponding changes in the apparent tissue sodium concentration (aTSC) measured with sodium ( 23 Na) MRI. Materials and Methods: Fourteen healthy subjects (7 female, 7 male; 25.0 ± 2.8 years) underwent 39 K and 23 Na MRI at a 7 T MR system, as well as 1 H MRI at a 3 T MR system. Magnetic resonance imaging data and blood samples were collected at baseline (t0), directly after performing eccentric exercise (t1) and 48 hours after exercise (t2). Self-reported muscle soreness was evaluated using a 10-cm visual analog scale for pain (0, no pain; 10, worst pain) at t0, t1, and t2. Quantification of aTPC/aTSC was performed after correcting the measured 39 K/ 23 Na signal intensities for partial volume and relaxation effects using 5 external reference phantoms. Edema volume and 1 H T 2 relaxation times were determined based on the 1 H MRI data. Participants were divided according to their increase in creatine kinase (CK) level into high (CK t2 ≥ 10•CK t0 ) and low CK (CK t2 < 10•CK t0 ) subjects.Results: Blood serum CK and edema volume were significantly increased 48 hours after exercise compared with baseline ( P < 0.001). Six participants showed a high increase in blood serum CK level at t2 relative to baseline, whereas 8 participants had only a low to moderate increase in blood serum CK. All participants reported increased muscle soreness both at rest and when climbing stairs at t1 (0.4 ± 0.7; 1.4 ± 1.2) and t2 (1.6 ± 1.4; 4.8 ± 1.9) compared with baseline (0 ± 0; 0 ± 0). Moreover, aTSC was increased at t1 in exercised muscles of all participants (increase by 57% ± 24% in high CK, 73% ± 33% in low CK subjects). Forty-eight hours after training, subjects with high increase in blood serum CK still showed highly increased aTSC (increase by 79% ± 57% compared with t0). In contrast, aTPC at t2 was elevated in exercised muscles of low CK subjects (increase by 19% ± 11% compared with t0), in which aTSC had returned to baseline or below. Overall, aTSC and aTPC showed inverse evolution, with changes in aTSC being approximately twice as high as in aTPC. Conclusions: Our results showed that 39 K MRI is able to detect changes in muscular potassium concentrations caused by eccentric exercise. In combination with 23 Na MRI, this enables a more holistic analysis of tissue ion concentration changes.

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MRI of Potassium and Sodium Enables Comprehensive Analysis of Ion Perturbations in Skeletal Muscle Tissue After Eccentric Exercise

et al. 2022

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“…The B 0 inhomogeneity was corrected by calculating the 23 Na Δ B 0 maps as described in Gast et al 22 Here, the 23 Na Δ B 0 maps were calculated based on the first two 23 Na-MRSI phase-unwrapped images (…”

Section: Post-processingmentioning

confidence: 99%

Fast in vivo²³Na imaging and T₂^*mapping using accelerated 2D-FID magnetic resonance spectroscopic imaging at 3 T: Proof of concept and reliability study

Alhulail

Xia

Shen

et al. 2020

Preprint

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PurposeTo implement an accelerated MR-acquisition method allowing to map sodium T2* relaxation and absolute concentration within skeletal muscles at 3T.MethodsA fast-2D density-weighted concentric-ring-trajectory 23Na-MRSI technique was used to acquire 64 time-points of FID with a spectral bandwidth of 312.5 Hz from a 2.5 x 2.5 mm2 in-plane resolution within about 15 minutes. The fast relaxing 23Na signal was localized with a single-shot, inversion-recovery based, non-echo (SIRENE) OVS method. The sequence was verified using simulation and phantom studies before implementing it in human calf muscles. Within two same-day sessions, 2D-SIRENE-MRSI (UTE = 0.55 ms) and 3D-MRI (UTE = 0.3 ms) data were acquired. The T2* values were fitted voxel-by-voxel using a bi-exponential model for the 2D-MRSI data. Within-subject coefficients of variation were estimated for both acquisition methods.ResultsThe MRSI-FID data allowed for fast and slow T2* mapping of the calf muscles in vivo with minimal sensitivity reduction. The spatial-distributions of 23Na concentration for both in vivo MRSI and 3D-MRI acquisitions were significantly correlated (r = 0.7, P<0.001). The test-retest results rendered high reliability for both MRSI (CV = 5%) and 3D MRI (CV = 6%). The mean in calf muscles was 0.7 ± 0.1 (contribution fraction = 37%), while was 13.2 ± 0.2 ms (63%). The mean absolute muscle 23Na concentration calculated from the T2*-corrected data was 28.6 ± 3.3 mM.ConclusionThe proposed MRSI technique is a reliable technique to map sodium’s absolute concentration and T2* within a clinically acceptable scan time at 3T.

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Frontiers of Sodium MRI Revisited: From Cartilage to Brain Imaging

Zaric

Juráš

Szomolányi

et al. 2020

Magnetic Resonance Imaging

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Sodium magnetic resonance imaging ( 23 Na-MRI) is a highly promising imaging modality that offers the possibility to noninvasively quantify sodium content in the tissue, one of the most relevant parameters for biochemical investigations. Despite its great potential, due to the intrinsically low signal-to-noise ratio (SNR) of sodium imaging generated by low in vivo sodium concentrations, low gyromagnetic ratio, and substantially shorter relaxation times than for proton ( 1 H) imaging, 23 Na-MRI is extremely challenging. In this article, we aim to provide a comprehensive overview of the literature that has been published in the last 10-15 years and which has demonstrated different technical designs for a range of 23 Na-MRI methods applicable for disease diagnoses and treatment efficacy evaluations. Currently, a wider use of 3.0T and 7.0T systems provide imaging with the expected increase in SNR and, consequently, an increased image resolution and a reduced scanning time. A great interest in translational research has enlarged the field of sodium MRI applications to almost all parts of the body: articular cartilage tendons, spine, heart, breast, muscle, kidney, and brain, etc., and several pathological conditions, such as tumors, neurological and degenerative diseases, and others. The quantitative parameter, tissue sodium concentration, which reflects changes in intracellular sodium concentration, extracellular sodium concentration, and intra-/extracellular volume fractions is becoming acknowledged as a reliable biomarker. Although the great potential of this technique is evident, there must be steady technical development for 23 Na-MRI to become a standard imaging tool. The future role of sodium imaging is not to be considered as an alternative to 1 H MRI, but to provide early, diagnostically valuable information about altered metabolism or tissue function associated with disease genesis and progression. Level of Evidence: 1 Technical Efficacy Stage: 1

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Localized B₀ shimming based on ²³Na MRI at 7 T

Cited by 11 publications

References 21 publications

MRI of Potassium and Sodium Enables Comprehensive Analysis of Ion Perturbations in Skeletal Muscle Tissue After Eccentric Exercise

MRI of Potassium and Sodium Enables Comprehensive Analysis of Ion Perturbations in Skeletal Muscle Tissue After Eccentric Exercise

Fast in vivo²³Na imaging and T₂^*mapping using accelerated 2D-FID magnetic resonance spectroscopic imaging at 3 T: Proof of concept and reliability study

Frontiers of Sodium MRI Revisited: From Cartilage to Brain Imaging

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Localized B0 shimming based on 23Na MRI at 7 T

Cited by 11 publications

References 21 publications

MRI of Potassium and Sodium Enables Comprehensive Analysis of Ion Perturbations in Skeletal Muscle Tissue After Eccentric Exercise

MRI of Potassium and Sodium Enables Comprehensive Analysis of Ion Perturbations in Skeletal Muscle Tissue After Eccentric Exercise

Fast in vivo23Na imaging and T2*mapping using accelerated 2D-FID magnetic resonance spectroscopic imaging at 3 T: Proof of concept and reliability study

Frontiers of Sodium MRI Revisited: From Cartilage to Brain Imaging

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Localized B₀ shimming based on ²³Na MRI at 7 T

Fast in vivo²³Na imaging and T₂^*mapping using accelerated 2D-FID magnetic resonance spectroscopic imaging at 3 T: Proof of concept and reliability study