2006
DOI: 10.1590/s1413-86702006000500013
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Localized hepatic tuberculosis presenting as fever of unknown origin

Abstract: Localized hepatic tuberculosis is a rare clinical form of tuberculosis infection; it has signs and symptoms related only to hepatic injury, with minimal or no extrahepatic involvement. It frequently presents as a non-specific syndrome, with systemic manifestations, which can sometimes result in a diagnostic dilemma. A high index of suspicion is required and a definitive diagnosis can be very difficult. We report a case of localized hepatic tuberculosis that presented as fever of unknown origin.

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Cited by 15 publications
(26 citation statements)
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“…It is believed that the route of transmission is different between the miliary TB and the primary liver TB. In the first one haematogenous dissemination of the bacteria seems to be the route of dissemination while in primary hepatic TB, the tubercle bacillus reaches the liver through the portal vein from the intestine 5. Primary liver TB was observed in about 1% of cases in two large hepatic TB series including 296 patients and in other studies 1 2 6.…”
Section: Discussionmentioning
confidence: 95%
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“…It is believed that the route of transmission is different between the miliary TB and the primary liver TB. In the first one haematogenous dissemination of the bacteria seems to be the route of dissemination while in primary hepatic TB, the tubercle bacillus reaches the liver through the portal vein from the intestine 5. Primary liver TB was observed in about 1% of cases in two large hepatic TB series including 296 patients and in other studies 1 2 6.…”
Section: Discussionmentioning
confidence: 95%
“…On the other hand, hepatic involvement can be seen in up to 80% of disseminated cases of TB 8. This disorder is referred to in the literature as atypical TB of the liver, tuberculous hepatitis, hepatic TB, hepatobiliary TB and localised or local hepatic TB 5. The most frequently encountered clinical laboratory findings of hepatic TB are hepatomegaly (90%), elevated alkaline phosphatase (80%), fever (70%), weight loss (60%), abdominal pain (50%), night sweats, anorexia and more seldom jaundice.…”
Section: Discussionmentioning
confidence: 99%
“…HTB also known as atypical tuberculosis of liver, hepatobiliary tuberculosis, localized hepatic tuberculosis, and isolated tuberculosis, is a rare and poorly defined disease of abdominal tuberculosis [2][3][4]. According to Leavine, Tubercli bacilli can reach liver by spread through hepatic artery, portal system or lymphatic tissue, categorized the disease into; miliary tuberculosis, pulmonary tuberculosis with hepatic involvement, primary hepatic tuberculosis, focal tuberculoma/abscess or tuberculous cholangitis [5].…”
Section: Discussionmentioning
confidence: 99%
“…Tuberculin test is not useful as yields false positive reaction and false negative results of cases with tuberculosis [2]. Laparoscopic liver biopsy was done and the specimen underwent for macroscopic and microscopic histopathological examinations, yield hepatic granuloma with central caseating necrosis.…”
Section: Discussionmentioning
confidence: 99%
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