Localized hepatic tuberculosis presenting as fever of unknown origin

Ferrari, Teresa Cristina Abreu; Couto, Carolina Mundim; Vilaça, Tatiane; Xavier, Marcelo Antônio Pascoal

doi:10.1590/s1413-86702006000500013

Cited by 17 publications

(30 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is believed that the route of transmission is different between the miliary TB and the primary liver TB. In the first one haematogenous dissemination of the bacteria seems to be the route of dissemination while in primary hepatic TB, the tubercle bacillus reaches the liver through the portal vein from the intestine 5. Primary liver TB was observed in about 1% of cases in two large hepatic TB series including 296 patients and in other studies 1 2 6.…”

Section: Discussionmentioning

confidence: 95%

“…On the other hand, hepatic involvement can be seen in up to 80% of disseminated cases of TB 8. This disorder is referred to in the literature as atypical TB of the liver, tuberculous hepatitis, hepatic TB, hepatobiliary TB and localised or local hepatic TB 5. The most frequently encountered clinical laboratory findings of hepatic TB are hepatomegaly (90%), elevated alkaline phosphatase (80%), fever (70%), weight loss (60%), abdominal pain (50%), night sweats, anorexia and more seldom jaundice.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatic tuberculoma mimicking hepatocellular carcinoma in an immunocompetent host

et al. 2013

View full text Add to dashboard Cite

Hepatic tuberculosis as a part of disseminated tuberculosis is seen in 50-80% of cases. Isolated hepatic tuberculosis is very uncommon even in countries with high prevalence of tuberculosis. It can occur as a primary case or due to reactivation of an old tubercular focus. We report a case of a 59-year-old Caucasian woman who presented with persistent right upper quadrant pain and a hepatic lesion on an abdominal CT. She had a history of pulmonary tuberculosis 15 years ago with localised lung tuberculosis treated with lobectomy and antituberculous drugs.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Hepatic tuberculoma mimicking hepatocellular carcinoma in an immunocompetent host

et al. 2013

View full text Add to dashboard Cite

show abstract

“…HTB also known as atypical tuberculosis of liver, hepatobiliary tuberculosis, localized hepatic tuberculosis, and isolated tuberculosis, is a rare and poorly defined disease of abdominal tuberculosis [2][3][4]. According to Leavine, Tubercli bacilli can reach liver by spread through hepatic artery, portal system or lymphatic tissue, categorized the disease into; miliary tuberculosis, pulmonary tuberculosis with hepatic involvement, primary hepatic tuberculosis, focal tuberculoma/abscess or tuberculous cholangitis [5].…”

Section: Discussionmentioning

confidence: 99%

“…Tuberculin test is not useful as yields false positive reaction and false negative results of cases with tuberculosis [2]. Laparoscopic liver biopsy was done and the specimen underwent for macroscopic and microscopic histopathological examinations, yield hepatic granuloma with central caseating necrosis.…”

Section: Discussionmentioning

confidence: 99%

“…The disease can start at any age and has been identified in primary and secondary tuberculosis. In the primary form, HTB can occurred via access of tubercular bacilli from primary infected source in bowel into the portal vein, while in the secondary form, it can occur as a disseminated diffuse hepatic tuberculosis, comes along with pulmonary or miliary tuberculosis [2,3]. Clinically, the disease may present with prolonged fever, poor gaining weight, abdominal discomfort and even serious manifestations of hepatic failure [4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A rare unusual case report of Hepatic Tuberculosis in a Yemeni Child, presented with Pyrexia of Unknown Origin

Muftah¹,

Mathouq²,

Zain³

2016

SJMCR

View full text Add to dashboard Cite

Hepatic Tuberculosis (HTB) is a rare form of tuberculosis. The disease presentation and characteristics have been described in a number of adult cases from low resource settings, however, little is known about the disease in children. We report a case of 9-year-old boy who had a prolonged history of fever. His clinical data were nonspecific. Laboratory and imaging data were not helpful. We did laparoscope biopsy of liver and histopathological study was done, which showed chronic granulomatous inflammation. He diagnosed as Hepatic Tuberculosis and received anti tuberculosis therapy; his condition got better. The age of our case indicates that the disease can infrequently occur in children in contrast to what is written in literature.

show abstract

Miliary tuberculosis in an immune‐competent Bangladeshi man—A case report

Paul

Ahmed

Chakrabortty

et al. 2023

Clinical Case Reports

View full text Add to dashboard Cite

Miliary tuberculosis (MTB) is a rare and fatal infectious disease that occurs due to the lympho-hematogenous spread of Mycobacterium tuberculosis bacilli. 1 According to the world health organization (WHO) 2021 reports, the incidence of tuberculosis in Bangladesh and Malaysia is around 221 and 97 per 100,000 people, respectively. It involves commonly the lung but may also affect other systems in the body. In all forms of tuberculosis cases, MTB occurs in 1%-2%, and in extrapulmonary tuberculosis, it is approximately 8%. 2 Clinical features of MTB are nonspecific, such as prolonged pyrexia, night sweats, weight loss, lassitude, anorexia, hepatomegaly, and abdominal pain. When the lungs are, an affected patient presents with cough, dyspnea, and chest pain. Occasionally, patients with miliary tuberculosis can present with "pyrexia of unknown origin" (PUO).Atypical clinical manifestation often delays the diagnosis and may cause a fatal outcome. Therefore, a high index of clinical suspicion is needed to diagnosing of MTB. Chest radiography plays a vital role in the initial detection and final diagnosis of MTB, but miliary mottling is seen in only 50% of cases of miliary tuberculosis. 3 Only one-third of MTB patients are sputum smear-positive. Histological demonstration of granulomatous inflammation in biopsy tissue (e.g., liver, lung, and bone marrow) is usually required to make a prompt diagnosis. 4 The molecular diagnosis of mycobacterium tuberculosis DNA by polymerase chain reaction is helpful, and it is rapid, sensitive, and specific. 5 MTB is more likely to see in an immune-compromised patient due to suppression of their cellular immunity and is rarely affected in an immune-competent patient.Herein, we reported a case of miliary tuberculosis in an immune-competent Bangladeshi man presented with pyrexia of unknown origin and hyponatremia.

show abstract

Localized hepatic tuberculosis presenting as fever of unknown origin

Cited by 17 publications

References 16 publications

Hepatic tuberculoma mimicking hepatocellular carcinoma in an immunocompetent host

Hepatic tuberculoma mimicking hepatocellular carcinoma in an immunocompetent host

A rare unusual case report of Hepatic Tuberculosis in a Yemeni Child, presented with Pyrexia of Unknown Origin

Miliary tuberculosis in an immune‐competent Bangladeshi man—A case report

Contact Info

Product

Resources

About