Localized Forms of Scleroderma

Gilliam, Amy E.; Gilliam, Anita C.

doi:10.1007/978-1-4419-5774-0_12

Cited by 3 publications

(3 citation statements)

References 203 publications

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“…11 According to the literature data, there is no connection between antinuclear factor detection and any clinical form of JLS. 5 In our series sclerodermospecific antibodies and ds-DNA were detected in small percentage of ArIn patients and in none without it. It is no wonder, because these antibodies are mainly found in JSS.…”

Section: Resultssupporting

confidence: 48%

“…4 There are some data stating that antinuclear factor directly correlates with joint lesions. 5 Patients with rheumatic conditions often have mixed cryoglobulins, composed of class M and rheumatoid factor immunoglobulins, class G polyclonal immunoglobulins and fibronectin. The level of cryoglobulins also correlates with clinical and laboratory activity of scleroderma.…”

Section: Introductionmentioning

confidence: 99%

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Articular involvement in juvenile localized scleroderma

Mk¹,

Na²,

Ov³

2018

MOJOR

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The articular involvement (ArIn) of juvenile localized scleroderma was studied retrospectively in 190 patients with juvenile localized scleroderma patients. Of these ArIn was detected in 125 patients (65,7%), among them 99% were in cases of linear and unilateral form of JLS. It was presented by joint pain in 25% of patients, limitation of joint movement in 62% of affected patients, mostly due to periarticular induration or tissue fibrosis, joint effusions -in 1% of ArIn. 25 % of affected children complained of joint pain. Limitation of joint movements was mostly (in 70%) due to the induration of soft tissue and skin around the joint and was reversible under therapy. Joint effusions were observed in 1% of ArIn. Ultrasound investigation imaging showed slight "subclinical" -synovitis and tenosynovitis in 80% of ArIn parients. Joint space narrowing by X-ray was detected in 12, articular erosions -in 2 children. In 1 girl with unilateral scleroderma MRI with contrasting detected avascular osteonecrosis of tibia. The levels of detected autoantibodies and markers of fibrosis were significantly higher in the patients with ArIn. All the patients with ArIn received immunodepressant therapy -glucocorticosteroids (GC) orally 1mg\kilo for 6-8 weeks, then tapered and withdrawn through the 3-6 months, and methotrexate (MTX) parenterally 12mg\ sq.m. for at least 2 years. In 76% of cases of ArIn this treatment increased range of joint movements or stopped flexion contractures. Therapeutic efficacy was worse in prolonged JLS with ArIn.

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Section: Resultssupporting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Articular involvement in juvenile localized scleroderma

Mk¹,

Na²,

Ov³

2018

MOJOR

View full text Add to dashboard Cite

show abstract

“…In the line of German classification, gLoS is diagnosed when at least three anatomical sites are affected . Furthermore, some authors acknowledge that gLoS is a term used to describe lesions covering more than 30% of the body surface …”

Section: Resultsmentioning

confidence: 99%