Localized fibrous mesothelioma of the mediastinum devoid of pleural connections

Solitary fibrous tumours of the pleura

“…They may show slow growth rate over time and may reach very large sizes [65]. Large lesions and those that arise from paramediastinal pleural surfaces may manifest with typical radiographic features of pulmonary or mediastinal masses, respectively [31,66]. Pleural effusion is reported in 6-17% of patients [10,30,35].…”

“…The currently accepted nomenclature is localized (solitary) fibrous tumour of the pleura, and a derivation from submesothelial mesenchymal cells with a fibroblastic differentiation is generally acknowledged [30]. Lesions of similar histological characteristics have been reported in extrapleural thoracic locations, including the mediastinum, lung, pericardium and heart [31][32][33]. Yousem and Flynn [34] described three intrapulmonary localized fibrous tumours and suggested the tissues in the interlobular septa as a common origin for this subset of lesions.…”

“…However, it should be noted that lesions of identical histological characteristics (i.e. localized fibrous tumours) may arise in the mediastinum without any relationship to the pleura [31]. Mass effect on the adjacent lung and mediastinum was described as a typical finding [62].…”

Malignant solitary fibrous tumor with superior vena cava syndrome

“…2 Preoperative diagnosis of mediastinal SFT is challenging, as it is diffi cult to differentiate SFTs from other mediastinal tumors. 4,5 In addition, mediastinal SFT is quite rare. Witkin and Rosai reported 14 mediastinal SFTs and concluded that this condition is more likely to display aggressive behavior than SFT of the pleura.…”

“…2 SFT rarely occurs in the mediastinum. [3][4][5] Compared to parietal and visceral SFTs, mediastinal SFT is more aggressive. 3 We report a case of malignant SFT with superior vena cava (SVC) syndrome that rapidly relapsed following surgery and radiotherapy.…”