Localized Eruptive Blue Nevi after Herpes Zoster

Colson, Fany; Arrese, Jorge E.; Nikkels, Arjen F.

doi:10.1159/000446178

Cited by 5 publications

(9 citation statements)

References 12 publications

(29 reference statements)

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“…25 Lesions of BN have also been named based on their evolutionary history; the term 'eruptive BN' is used to describe multiple lesions appearing in a short period of time. 27 Trauma, puberty, sunburn and pregnancy have been accused as triggering factors for this rare presentation. 27,28 Many atypical morphological presentations of BN have also been described.…”

Section: Blue Naevusmentioning

confidence: 99%

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The spectrum of benign dermal dendritic melanocytic proliferations

Baykal

Yılmaz

Sun

et al. 2019

Acad Dermatol Venereol

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Dermal melanocytoses (DMs) comprise a heterogeneous group of benign lesions, located on skin and mucous membranes, characterized by dendritic melanocytes in the dermis. Although they share common histopathological features, some variants may present only as bluish or grey patches, some only as papules/nodules/plaques and others may show combination of all of these lesions. Despite the fact that blue naevus (BN) is typically characterized with papulonodular lesions, its variants may show all of the aforementioned presentations. Mongolian spot, naevus of Ota and naevus of Ito are patchy DMs distinguished by their specific localizations. Apart from these classical forms, many atypical variants without unique clinicopathological characteristics have been described in the literature making the nomenclature of DMs more complicated. However, congenital dermal melanocytosis and acquired dermal melanocytosis seem to be crucial umbrella terms that encompass all patchy DMs in atypical locations. Papules or subcutaneous nodules on patchy lesions and association of epidermal pigmentation presenting as brownish patches may be encountered as rare features of DMs. On the other hand, delayed‐onset subcutaneous nodules may be typical presentations of melanoma in patchy DMs; therefore, they deserve special attention. Large plaque‐type BN with subcutaneous cellular nodules is a newly described entity, harbouring clinical features of various DMs together and has a high risk of melanoma. The whole spectrum of dermal dendritic melanocytic proliferations is discussed including novelties and controversial issues.

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Section: Blue Naevusmentioning

confidence: 99%

“…27 Trauma, puberty, sunburn and pregnancy have been accused as triggering factors for this rare presentation. 27,28 Many atypical morphological presentations of BN have also been described. Target-like appearance defines a pigmented central portion surrounded by a skin-coloured area and an outer ring-like pigmentation.…”

Section: Blue Naevusmentioning

confidence: 99%

The spectrum of benign dermal dendritic melanocytic proliferations

Baykal

Yılmaz

Sun

et al. 2019

Acad Dermatol Venereol

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“…There are several case reports that have documented the development of bona fide melanocytic naevi, including so-called “eruptive blue naevi” at sites of sunburn [21], previous trauma [22], and infection [23]. Mechanisms that have been proposed are the release of growth factors from keratinocytes and inflammatory cells triggering melanocyte proliferation [21,22,23]. To the best of the authors' knowledge, this is the first report of a conjunctival blue naevus occurring in an anophthalmic socket.…”

Section: Discussionmentioning

confidence: 99%

Conjunctival Blue Naevus in an Anophthalmic Socket

2017

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Purpose of the Study: To describe an unusual brown pigmented lesion of the conjunctiva in an anophthalmic socket in a 16-year-old male. Procedures: A 16-year-old male patient presented with socket irritation whilst wearing an artificial eye due to meibomian gland dysfunction. An area of flat, subepithelial, dark brown pigmentation with irregular and indistinct borders on the bulbar conjunctiva of the anophthalmic socket was seen. The patient believed it had been present for at least 2 years. His past ocular history was of childhood trauma to the right eye at the age of 9 years, and he underwent primary enucleation and hydroxyapatite orbital implant insertion at that time. Unfortunately, the implant extruded and was removed a year later. Results: An incisional biopsy of the pigmented lesion showed a conjunctival, subepithelial bland spindle cell melanocytic lesion, with uniform-sized and -shaped melanosomes. Immunohistochemistry showed the cells to express Melan A and HMB45 and they were negative for CD68 and pan-cytokeratins. The features were of a common blue naevus. Conclusion: This is the first documentation of a post-enucleation conjunctival naevus in an anophthalmic socket. We propose a pathogenesis and suggest surveillance as there is a risk of transformation to melanoma.

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“…This condition is characterized by a rapid appearance of multiple melanocytic nevi mainly developed in immunosuppressed patients or those affected by blistering disease, varicella zoster virus infection, severe sunburn, or trauma. [23]…”

mentioning

confidence: 99%

“…The abrupt eruption of melanocytic lesions may also occur in physiological conditions such as puberty or pregnancy. [3]…”

mentioning

confidence: 99%