Localized bullous pemphigoid: Four clinical cases and a literature review

Abstract

Localized bullous pemphigoid (LBP) rarely evolves into the generalized form, and the prognosis is better. In our opinion, the occurrence of LBP is underestimated because of incorrect diagnoses. It is therefore important to perform a skin biopsy each time a bullous rash is concerned in order to make a definite diagnosis.

Unusual Presentations of Bullous Pemphigoid in Young Patients: A Case Series

“…In the second patient, vesicles and bullae were predominantly present over the face and extremities. Localized BP is an unusual variant with less than 20 cases reported in young people so far (11), with the most common site being lower limbs or over surgical/burn/trauma scar, radiation therapy, and phototherapy site (12), but in our case, it developed de novo over the right forearm. The bullae are typically filled with serous fluid but may be hemorrhagic with a positive bulla spread sign and negative Nikolsky's sign.…”

Successful excision of localized bullous pemphigoid on the unilateral areola

“…Localized BP frequently occurs on the legs, palms, or soles, and occasionally at sites of prior radiation, surgery, or trauma. 1,4 In our case, the patient did not have such triggers.…”

“…This is the first report of successful excision. Localized BP usually responds better to topical steroids; 3,4 however, this case showed resistance to them despite being a small lesion.…”

Blisters and Milia around the Peritoneal Dialysis Catheter: A Case of Localized Bullous Pemphigoid

“…The clinical manifestation might mimic a contact dermatitis, a more common and benign dermatologic condition, a bacterial infection, which is a serious and potentially fatal event, or other conditions, delaying a proper diagnosis and treatment. In general, localized BP has a more benign disease course because it responds better to local treatments than the generalized form [ 25 ]. Moreover, the removal of the PD catheter was not required in our case or in the one described by Giunzioni [ 11 ].…”

“…Moreover, the removal of the PD catheter was not required in our case or in the one described by Giunzioni [ 11 ]. Nevertheless, the localized disease may precede a diffuse involvement and a regular follow-up is necessary [ 25 ].…”