“…The clinical characteristics of SFTP have been recognized increasingly over the past 20 years. It is diffi cult to diagnosis SFTP based on radiological image before surgery, and it is often impossible to determine whether the tumor is malignant or benign by chest X-ray and CT. 1,7) The diagnosis of SFTP can be confi rmed by typical histomorphologic fi ndings of short spindle neoplastic cells admixed with variable amount of collagen growing in a 'patternless' and/or hemangiopericytoma-like manner combined with matching immunohistochemical staining (positive for CD 34, vimentin, desmin, bcl-2, CD 99, but negative for EMA, S-100 and keratin). 8) Criteria of malignancy, as reported by England, et al, 2) includes high cellularity with crowding and overlapping of nuclei, high mitotic activity (more than 4 mitotic fi gures per 10 highpower fi elds), and signifi cant cellular pleomorphism.…”
“…The clinical characteristics of SFTP have been recognized increasingly over the past 20 years. It is diffi cult to diagnosis SFTP based on radiological image before surgery, and it is often impossible to determine whether the tumor is malignant or benign by chest X-ray and CT. 1,7) The diagnosis of SFTP can be confi rmed by typical histomorphologic fi ndings of short spindle neoplastic cells admixed with variable amount of collagen growing in a 'patternless' and/or hemangiopericytoma-like manner combined with matching immunohistochemical staining (positive for CD 34, vimentin, desmin, bcl-2, CD 99, but negative for EMA, S-100 and keratin). 8) Criteria of malignancy, as reported by England, et al, 2) includes high cellularity with crowding and overlapping of nuclei, high mitotic activity (more than 4 mitotic fi gures per 10 highpower fi elds), and signifi cant cellular pleomorphism.…”
“…Waite et al [9] demonstrated that 96% of patients with empyema and up to 10% of patients with malignant effusions showed parietal pleural enhancement; 95% of the latter are metastatic in origin, with common primaries being lung and breast, while mesothelioma accounts for 5% [11]. Localised fibrous tumours involving the pleura also exhibit intense homogeneous contrast enhancement on CT [11][12][13]. Our study demonstrates significantly higher pleural enhancement (83 HU) in patients receiving more contrast at a higher rate than in patients receiving a smaller traditional volume (59 HU) (Figure 1).…”
Objectives: Imaging of the pleura by multidetector CT (MDCT) can be challenging. There is no clear evidence or guidelines on contrast infusion parameters for imaging pleura. We compared two contrast protocols for assessing pleural pathology on MDCT.Methods: This was a prospective study in which consecutive patients with MDCT for suspected pleural disease on chest radiograph were randomised into two groups. The first group received 150 ml of intravenous contrast at a rate of 2.5 ml s -1 and the second group received 100 ml at 2 ml s -1. Images were acquired after a 60 s delay. Hounsfield units of the pleura, thoracic aorta, main pulmonary artery, portal vein and superior mesenteric artery were measured and analysed by two independent readers. Results: 40 patients (20 in each group) who had pleural enhancement on MDCT were included for final analysis. The mean pleural enhancement value was 83 HU (Group A) vs 59 HU (Group B) (p50.0004). The mean aortic enhancement was 241 HU (A) vs 141 HU (B) (p,0.0001); main pulmonary artery enhancement was 208 HU (A) vs 139 HU (B) (p,0.0002); portal venous enhancement was 169 HU (A) vs 115 HU (B) (p,0.0001); and the superior mesenteric artery enhancement was 215 HU (A) vs 128 HU (B) (p,0.0001). Conclusion: Enhancement of the pleura and major vessels was significantly higher in the group receiving more contrast at a greater infusion rate. This technique of a single scan through the entire pleural surface with a delayed acquisition is promising. When pleural disease is suspected, contrast infusion protocols should be modified to achieve the best results and clinicians should be encouraged to specifically request a ''pleural CT''.
“…Such features alert the radiologist to a possible SFT diagnosis. When the tumor is ≥10 cm in size with central necrosis and effusion, it is likely to be a malignant tumor (5,16,17).…”
Abstract. Solitary fibrous tumors (SFTs) are rare soft-tissue tumors of mesenchymal origin. Occasionally, these lesions have been indicated to associate with the salivary glands. Through the analysis of magnetic resonance imaging sequences, the present study reports a case of a solitary salivary gland lesion, demonstrating a well-circumscribed, soft-tissue tumor with marked signal changes and homogenous enhancement. SFT should be considered as a differential diagnosis when a solid mass exhibiting hypointensity on T1-weighted images and hyperintensity on T2-weighted images has been detected in the salivary gland. Due to the potentially malignant nature of SFTs, it is necessary for radiologists to improve their understanding of such lesions.
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