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1997
DOI: 10.2214/ajr.169.3.9275877
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Localized benign fibrous tumors of the pleura.

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Cited by 82 publications
(94 citation statements)
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“…The clinical characteristics of SFTP have been recognized increasingly over the past 20 years. It is diffi cult to diagnosis SFTP based on radiological image before surgery, and it is often impossible to determine whether the tumor is malignant or benign by chest X-ray and CT. 1,7) The diagnosis of SFTP can be confi rmed by typical histomorphologic fi ndings of short spindle neoplastic cells admixed with variable amount of collagen growing in a 'patternless' and/or hemangiopericytoma-like manner combined with matching immunohistochemical staining (positive for CD 34, vimentin, desmin, bcl-2, CD 99, but negative for EMA, S-100 and keratin). 8) Criteria of malignancy, as reported by England, et al, 2) includes high cellularity with crowding and overlapping of nuclei, high mitotic activity (more than 4 mitotic fi gures per 10 highpower fi elds), and signifi cant cellular pleomorphism.…”
Section: Discussionmentioning
confidence: 99%
“…The clinical characteristics of SFTP have been recognized increasingly over the past 20 years. It is diffi cult to diagnosis SFTP based on radiological image before surgery, and it is often impossible to determine whether the tumor is malignant or benign by chest X-ray and CT. 1,7) The diagnosis of SFTP can be confi rmed by typical histomorphologic fi ndings of short spindle neoplastic cells admixed with variable amount of collagen growing in a 'patternless' and/or hemangiopericytoma-like manner combined with matching immunohistochemical staining (positive for CD 34, vimentin, desmin, bcl-2, CD 99, but negative for EMA, S-100 and keratin). 8) Criteria of malignancy, as reported by England, et al, 2) includes high cellularity with crowding and overlapping of nuclei, high mitotic activity (more than 4 mitotic fi gures per 10 highpower fi elds), and signifi cant cellular pleomorphism.…”
Section: Discussionmentioning
confidence: 99%
“…Waite et al [9] demonstrated that 96% of patients with empyema and up to 10% of patients with malignant effusions showed parietal pleural enhancement; 95% of the latter are metastatic in origin, with common primaries being lung and breast, while mesothelioma accounts for 5% [11]. Localised fibrous tumours involving the pleura also exhibit intense homogeneous contrast enhancement on CT [11][12][13]. Our study demonstrates significantly higher pleural enhancement (83 HU) in patients receiving more contrast at a higher rate than in patients receiving a smaller traditional volume (59 HU) (Figure 1).…”
Section: Discussionmentioning
confidence: 99%
“…Such features alert the radiologist to a possible SFT diagnosis. When the tumor is ≥10 cm in size with central necrosis and effusion, it is likely to be a malignant tumor (5,16,17).…”
Section: Discussionmentioning
confidence: 99%