Localized amyloidosis in usual-type vulvar intraepithelial neoplasia: High-risk HPV association and potential clinical significance. A series of 45 cases

Abstract

Highlights Localized amyloidosis is only identified in Usual-type HPV-associated VINs. Subtypes of hrHPV in both localized amyloidosis and non-amyloid cases are similar. VINs with localized amyloidosis appear to have a better prognosis. Amyloid deposits persisted even after regression of VINs. Localized amyloid deposits in VINs may be a manifestation of body’s defense mechanism.