Localized 2D J-resolved 1H MR spectroscopy: Strong coupling effects in vitro and in vivo

Ryner, Lawrence; Sorenson, James A.; Thomas, M. Albert

doi:10.1016/0730-725x(95)00031-b

Cited by 120 publications

(118 citation statements)

References 11 publications

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“…CSSMRS may also be beneficial in a research setting in which sophisticated 2D MR spectroscopy experiments have inherently long acquisition times, such as J-resolved MR spectroscopy. 25 Another promising application of CSSMRS is in functional spectroscopy, in which real-time changes in metabolic information can be measured from multiple points within the brain simultaneously with high temporal resolution. Further development and applications of CSSMRS should be explored in the future.…”

Section: Discussionmentioning

confidence: 99%

Constrained Source Space MR Spectroscopy: Multiple Voxels, No Gradient Readout

Landheer¹,

Sahgal²,

Das³

et al. 2015

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

Constrained Source Space MR Spectroscopy: Multiple Voxels, No Gradient Readout

Landheer¹,

Sahgal²,

Das³

et al. 2015

AJNR Am J Neuroradiol

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“…However, due to their complex resonance patterns and high degree of overlap with each other as well as with more dominant resonances, simultaneous detection of these amino acids remains a difficult task. J-resolved methods have been investigated as a potential tool for unraveling the complex J-coupled spectral patterns of Glu and Gln in vivo, thus providing a higher degree of resolution and separation of the distinct spectral components (1,3,4,6,7). In the TE-averaged spectrum, the amplitude of the coupled resonance pattern is mostly cancelled out, resulting in a much smoother baseline and facilitating improved quantification.…”

Section: Introductionmentioning

confidence: 99%

Quantification of J‐resolved proton spectra in two‐dimensions with LCModel using GAMMA‐simulated basis sets at 4 Tesla

et al. 2009

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A two-dimensional, J-resolved magnetic resonance spectroscopic extraction approach was developed employing GAMMA-simulated, LCModel basis-sets. In this approach, a two-dimensional J-resolved (2D-JPRESS) dataset was resolved into a series of one-dimensional spectra where each spectrum was modeled and fitted with its theoretically customized LCModel template. Metabolite levels were derived from the total integral across the J-series of spectra for each metabolite. Phantoms containing physiologic concentrations of the major brain chemicals were used for validation. Varying concentrations of glutamate and glutamine were evaluated at and around their accepted in vivo concentrations in order to compare the accuracy and precision of our method with 30 ms PRESS. We also assessed 2D-JPRESS and 30 ms PRESS in vivo, in a single voxel within the parieto-occipital cortex by scanning ten healthy volunteers once and a single healthy volunteer over nine repeated measures. Phantom studies demonstrated that serial fitting of 2D-JPRESS spectra with simulated LCModel basis sets provided accurate concentration estimates for common metabolites including glutamate and glutamine. Our in vivo results using 2D-JPRESS suggested superior reproducibility in measuring glutamine and glutamate relative to 30 ms PRESS. These novel methods have clear implications for clinical and research studies seeking to understand neurochemical dysfunction.

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“…Among the simplest and most useful sequences for in vivo MRS is localised 2D Jresolved spectroscopy (JPRESS) (10,11). The J evolution is encoded in an additional indirect dimension by time shifting the last 1808 refocusing pulse.…”

Section: Introductionmentioning

confidence: 99%

ProFit: two‐dimensional prior‐knowledge fitting of J‐resolved spectra

2006

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A two-dimensional fitting procedure is introduced, capable of extracting the full amount of information from 2D J-resolved magnetic resonance spectroscopic data. The fitting procedure uses a linear combination of 2D model spectra. For reducing the degrees of freedom and increasing robustness, it is divided into a non-linear outer loop and an inner linear least-squares fit for the concentrations. In vitro and in vivo experiments on a whole-body 3 T MR scanner show the detectability of a wide range of metabolites in the human brain, namely total creatine, N-acetylaspartate, N-acetylaspartylglutamate, choline-containing compounds, glutamate, myo-inositol, glutathione, scyllo-inositol, gamma-aminobutyric acid, alanine and ascorbic acid.

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Localized 2D J-resolved 1H MR spectroscopy: Strong coupling effects in vitro and in vivo

Cited by 120 publications

References 11 publications

Constrained Source Space MR Spectroscopy: Multiple Voxels, No Gradient Readout

Constrained Source Space MR Spectroscopy: Multiple Voxels, No Gradient Readout

Quantification of J‐resolved proton spectra in two‐dimensions with LCModel using GAMMA‐simulated basis sets at 4 Tesla

ProFit: two‐dimensional prior‐knowledge fitting of J‐resolved spectra

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