Localization with Sr85 of Spinal Metastases in Mammary Cancer and Changes in Uptake after Hormone and Roentgen Therapy: A Preliminary Report

Abstract

Skeletal metastases are often not demonstrable in the roentgenogram until bone destruction is considerable. This applies particularly to the spine. A comparison between roentgen and postmortem findings, as well as experimental studies by BABAIANTZ, have shown that the bone decalcification must reach about 50 % before it is evident in the roentgen film.Investigations with so-called osseophil isotopes in recent decades have contributed considerably to our knowledge of the mineral metabolism of the skeleton. Such isotopes have also been used in the elaboration of methods enabling an earlier diagnosis of osseous tumours. The distribution of radiogallium (Ga 66 , Ga 6 7 and Ga 7 2 ) in the skeleton and their concentration in osseous lesions, particularly tumours, have been studied by DUDLEY et coll. (1950DUDLEY et coll. ( , 1956, DESGREZ (1954), DESGREZ et coll, (1954) and MULRY et coll.They have shown that occasionally an accumulation of radiogallium may be demonstrated in osseous tumours before it can be detected at roentgen examination.The method has been used in examinations for primary osseous tumours as well as skeletal metastases. DESGREZ et coll. claim to have shown that a tumour is sometimes more extensive than may be assumed from its roentgenographic appearance, an observation of importance in the radiotherapy

A Glance At The History Of Nuclear Medicine

“…After early trials, using '?P and 45Ca, a breakthrough came by the introduction of the gamma-emitting radionuclide "Sr. Gynning et al (41) used this radionuclide in external detection of spinal metastases. Cederqvist (42) performed retention studies in patients with and without widespread malignant skeletal disease using a whole body counter.…”

Atlas of Gallium-67 Scintigraphy

“…Strontium-85 was found to localize readily in areas of osteoblastic activity present in primary and metastatic bone lesions (8). However, the long half-life and energetic photon of 85-Sr were not satisfactory, and the search continued for a better bone imaging agent.…”

Βελτιωση Της Διαγνωστικης Αξιας Του Σπινθηρογραφηματος Των Οστων Με Τη Βοηθεια Ηλεκτρονικου Υπολογιστου

“…Tò πρώτο πού χρησιμοποιήθηκε ήταν τό στρόντιο-85 (άπό τους Gynning 43 Και Fleming 1961 35 ), το όποιο έχει τα έξης χαρακτηριστικά: εκπέμπει γ-άκτινοβολία ενεργείας 510 KeV και έχει φυσικό χρόνο υποδιπλασιασμού 64 ήμερες. Ή χορήγηση του ισοτόπου γίνεται ενδοφλέβια μέ τή μορφή 85 Sr-nitrate ή chloride σέ ποσότητα 50-100 μο, τό δέ σπινθηρογράφημα παίρνεται 2 ήμερες μετά τή χορήγηση.…”