Localization of tyrosine hydroxylase and olfactory marker protein immunoreactivities in the human and macaque olfactory bulb

Smith, Robin L.; Baker, Harriet; Kolstad, Kaare; Spencer, Dennis D.; Geer, Charles A.

doi:10.1016/0006-8993(91)91115-h

Cited by 58 publications

(50 citation statements)

References 30 publications

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“…The layers of the human olfactory bulb, especially the mitral cell layer [Smith et al, 1991], are not as clearly defi ned as those in other mammals [Zilles, 2004]. The superfi cial layer, consisting of fi bres of the olfactory nerve, begins to form in stage 18 and includes olfactory ensheathing cells by stage 19 ( fi g. 8 a).…”

Section: The Olfactory Bulbmentioning

confidence: 99%

“…In the human the pattern of lamination is polarized, i.e., it 'was only observed in the inferior half, in which the majority of olfactory nerve input was also found' [Chuah and Zheng, 1987] ( fi g. 1 and 3 at 14 GW). In the adult a well-defi ned mitral cell layer is unclear, and an internal plexiform layer is not readily apparent [Smith et al, 1991].…”

Section: The Olfactory Bulbmentioning

confidence: 99%

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Olfactory Structures in Staged Human Embryos

Müller¹,

OʼRahilly²

2004

Cells Tissues Organs

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The olfactory region was investigated in 303 serially sectioned human embryos, 23 of which were controlled by precise graphic reconstructions. The following findings in the embryonic period are new for the human. (1) The nasal plates arise at the neurosomatic junction, as do also the otic placodes. (2) Crest comes from the nasal plates later (stage 13) than the maximum production in the neural folds (stage 10). (3) The crest arises and migrates during a much longer time (at least until the end of the embryonic period) than the neural crest of the head, where origin and migration end at stage 12. (4) Olfactory nerve fibres enter the brain at stage 17, the vomeronasal fibres and those of the nervus terminalis at stages 17 and 18. (5) Fibre connections between the olfactory tubercle and the olfactory bulb, as well as those to the amygdaloid nuclei, forebrain septum, and hippocampus, develop during and after stage 17. (6) Mitral cells appear late in the embryonic period. (7) Localized, although incomplete, lamination of the olfactory bulb is detectable at the embryonic/fetal transition. (8) Tangential migratory streams of neurons, from stage 22 to the early fetal period, proceed from the subventricular zone of the olfactory bulb towards the future claustrum; they remain within the insular region but are separated from the cortical plate. (9) In future cebocephaly morphological indications may be visible as early as stage 13. The various findings are integrated by means of staging, and current information for the fetal period is tabulated from the literature.

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Section: The Olfactory Bulbmentioning

confidence: 99%

Section: The Olfactory Bulbmentioning

confidence: 99%

Olfactory Structures in Staged Human Embryos

Müller¹,

OʼRahilly²

2004

Cells Tissues Organs

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“…In rodents, six well-defined layers are described in the OB. In humans they are not as clearly defined, although the main cells types of each can be identified 37 . The olfactory nerve layer is the most superficial layer of the OB.…”

Section: Olfactory Bulbmentioning

confidence: 99%

“…The internal plexiform layer is another layer with few cells bodies: it mainly combines the dendritic process of granule cells and the axons of the mitral and tufted cells. Similar to the external plexiform layer, in humans it also merges with the mitral cell layer 37 . The granule cell layer has the most numerous cell structures in the rodent olfactory bulb, with a few million neurons.…”

mentioning

confidence: 99%

The Hitchhiker’s guide to the rhinencephalon

Silveira‐Moriyama

Glass

Rajan

et al. 2016

Arq. Neuro-Psiquiatr.

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Pathology of the rhinencephalon has been a subject of interest in the fields of neurodegenerative diseases, trauma, epilepsy and other neurological conditions. Most of what is known about the human rhinencephalon comes from comparative anatomy studies in other mammals and histological studies in primates. Functional imaging studies can provide new and important insight into the function of the rhinencephalon in humans but have limited spatial resolution, limiting its contribution to the study of the anatomy of the human rhinencephalon. In this study we aim to provide a brief and objective review of the anatomy of this important and often overlooked area of the nervous system.

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“…Tissues of bowhead whales were sampled under NOAA/NMFS permit 814-1899, and the preparation of tissue sections (thickness: 6 um) was described previously (Thewissen et al 2011). Glomeruli are labeled by the expression of olfactory marker protein (OMP) (Danciger et al 1989;Smith et al 1991). The ImmunoCruz goat ABC staining system (Santa Cruz Biotechnology, Inc., cat no.…”

Section: Methodsmentioning

confidence: 99%

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Supplemental Information 7: Table S1

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Although modern baleen whales still possess a functional olfactory systems that includes olfactory bulbs, cranial nerve I and olfactory receptor genes, their olfactory capabilities have been reduced profoundly. This is probably in response to their fully aquatic lifestyle.The glomeruli that occur in the olfactory bulb can be divided into two non-overlapping domains, a dorsal domain and a ventral domain. Recent molecular studies revealed that all modern whales have lost olfactory receptor genes and marker genes that are specific to the dorsal domain, and that a modern baleen whale possess only 60 olfactory receptor genes. Here we show that olfactory bulb of bowhead whales (Balaena mysticetus, Mysticeti) lacks glomeruli on the dorsal side, consistent with the molecular data. In addition, we estimate that there are more than 4,000 glomeruli in the bowhead whale olfactory bulb. Olfactory sensory neurons that express the same olfactory receptor in mice generally project to two specific glomeruli in an olfactory bulb, meaning that ratio of the

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Localization of tyrosine hydroxylase and olfactory marker protein immunoreactivities in the human and macaque olfactory bulb

Cited by 58 publications

References 30 publications

Olfactory Structures in Staged Human Embryos

Olfactory Structures in Staged Human Embryos

The Hitchhiker’s guide to the rhinencephalon

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