Localization of tumor suppressor activity important in nonsmall cell lung carcinoma on chromosome 11q

Abstract

Loss of heterozygosity on chromosome 11q23 is observed at high frequency in human nonsmall cell lung carcinomas (

Gadd45a inhibits cell migration and invasion by altering the global RNA expression

“…The cell adhesion molecules (CAMs) (including immunoglobulin and calcium-dependent collagen type III α 1 and typeIα 2 have been reported to be overexpressed in ovarian and gastric carcinomas, 24,25 we verified the diverse kinds of cancers, including breast cancer, lung cancer and esophageal squamous cell carcinoma. [30][31][32] In addition to the aberration, it is also reported that the promoter methylation plays a role in the reduction of TSLC1. 33,34 Integrins, which link cell to extracellular matrix substrates, also appear to play critical roles in the processes of metastasis.…”

Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer

“…TSLC1/IGSF4 encoding an immunoglobulin superfamily member was recently cloned from a genomic fragment corresponding to 11q23.2, based on its functional competency in the suppression of the tumorigenicity of human A549 and mouse Lewis lung cancer cell lines (Murakami et al, 1998). Although TSLC1 appears to carry mutations rather infrequently, expression of TSLC1 has been shown to be frequently reduced by DNA hypermethylation of its promoter region (Kuramochi et al, 2001).…”

Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22

“…Even tumors that have arisen through multiple genetic alterations on di erent chromosomes have been reverted to a less tumorigenic phenotype, indicating that introduction of a single TSG may be su cient to suppress tumor growth. More recently, functional complementation using YAC clones has been used successfully to further localize putative TSGs to individual YACs, which are more amenable to positional cloning approaches (Koreth et al, 1999;Murakami et al, 1998;Reddy et al, 2000).…”