Localization of three subtypes of Fcγ receptors in human placenta by immunohistochemical analysis

Kameda, Takashi; Koyama, Masayasu; Matsuzaki, Noboru; Taniguchi, Takeshi; Saji, Fumitaka; Takahashi, Osamu

doi:10.1016/0143-4004(91)90506-b

Cited by 69 publications

(46 citation statements)

References 13 publications

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“…Such transport is active and depends on the presence of cell receptors [Kameda et al, 1991;Simister and Story, 1997]. A correlation has been found between gestational age and IgG concentration at birth [Toivanen et al, 1968].…”

Section: Introductionmentioning

confidence: 96%

Placental transfer of naturally acquired, maternal cytomegalovirus antibodies in term and preterm neonates

Mussi-Pinhata¹,

Pinto²,

Yamamoto³

et al. 2002

Journal of Medical Virology

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Maternal antibodies may protect the fetus and neonate against severe forms of CMV-caused disease, therefore this study investigated the efficiency of the placental transfer of naturally acquired, maternal total anti-cytomegalovirus (CMV) IgG and neutralizing antibodies at different gestational ages. The study was conducted on 182 healthy CMV-seropositive Brazilian mothers and their 196 infants who were not infected congenitally with CMV, as determined by CMV detection in urine. The study groups were composed of 44 infants aged 28-30 weeks; 51 infants aged 31-33 weeks; 62 infants aged 34-36 weeks, and 39 infants of gestational age > or = 37 weeks. Quantitative detection of total CMV IgG was carried out using EIA and virus neutralizing titers were determined by a microneutralization assay in sera from mothers and infants. CMV IgG levels and neutralizing titers of the infants correlated with maternal levels (r=0.873 and r=0.841, respectively). The efficiency of placental transfer of these antibodies was enhanced significantly as gestation progressed until 34-36 weeks, when values similar to those of full-term infants (90-100%) were found. Transfer ratios were significantly higher for neutralizing compared to total CMV IgG antibodies at gestational age 31-33 weeks (100% vs. 84%, respectively) and at gestational age 28-30 weeks (75% vs. 60%, respectively). We conclude that placental transfer of naturally acquired maternal CMV neutralizing and total CMV IgG antibodies are similarly efficient above 34 weeks of gestational age. At less than 34 weeks of gestational age, transfer of neutralizing antibodies may be favored and these antibodies reach the neonatal serum of 99% of these premature infants.

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Section: Introductionmentioning

confidence: 96%

Placental transfer of naturally acquired, maternal cytomegalovirus antibodies in term and preterm neonates

Mussi-Pinhata¹,

Pinto²,

Yamamoto³

et al. 2002

Journal of Medical Virology

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“…However, in the third trimester, the number of cytotrophoblasts is greatly reduced and the feto-maternal barrier then consists of the syncytiotrophoblast and the fetal capillary endothelium [5]. Although Fc receptors have been localized in syncytiotrophoblast as well as in fetal endothelial cells [4,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]], the precise mechanism by which IgG crosses the term placenta is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Expression of placental alkaline phosphatase does not correlate with IgG binding, internalization and transcytosis

Stefaner

Stefanescu

Hunziker

et al. 1997

Biochemical Journal

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The human homologue of FcRn, an IgG Fc receptor expressed in rat villous syncytiotrophoblasts, might be involved in IgG transfer from the maternal to the fetal circulation. However, because the receptor does not bind IgG at the physiological pH of the maternal blood (pH 7.4), FcRn is probably not involved in the initial uptake of IgG. A role in IgG internalization has been suggested for placental alkaline phosphatase (PLAP), which is highly expressed on the apical surface of syncytiotrophoblasts. To determine whether PLAP does indeed have a role in IgG uptake, we analysed the ability of PLAP to bind, internalize and transcytose IgG in BeWo choriocarcinoma cells endogenously expressing the protein, or in Madin-Darby canine kidney (MDCK) cells transfected with the PLAP cDNA. Although PLAP expression in MDCK cells resulted in increased IgG binding to intact cells, binding was not correlated with the level of PLAP expressed in the different cell lines. Furthermore our findings do not support a role for PLAP in IgG endocytosis or transcytosis.

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“…A presença de receptores para a região Fc de IgG tem sido demonstrada na placenta humana já nas primeiras 12 semanas de idade gestacional. O sinciciotrofoblasto e as células de Hofbauer são as principais células que possuem os receptores Fc 40 . Todas as quatro subclasses de IgG (IgG1, IgG2, IgG3 e IgG4) atravessam a placenta.…”

Section: Imunidade Passivamente Adquiridaunclassified

Immunological peculiarities of extremely preterm infants: a challenge for the prevention of nosocomial sepsis

Mussi-Pinhata¹,

Rego²

2005

J Pediatr (Rio J)

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Como citar este artigo: Mussi-Pinhata MM, Rego MA. Particularidades imunológicas do pré-termo extremo: um desafio para a prevenção da sepse hospitalar. J Pediatr (Rio J). 2005;81(1 Supl):S59-S68. AbstractObjective: To review the main aspects of fetal immune development focusing on the host defenses of extremely preterm infants against bacterial pathogens, and describing the possibilities of immunotherapeutic intervention for the prevention of neonatal nosocomial sepsis.Sources of data: Electronic search of MEDLINE database for articles published in the last 15 years. Those with relevant information regarding the target issue were selected.Summary of the findings: Immunity of extremely preterm infants is deficient due to skin fragility, insufficient complement system components, decreased bone marrow neutrophil storage pool, and lower chemotaxis, adherence, deformability, and neutrophil enzyme activities. Further limitations are found at NK cell-mediated cytotoxicity, T cell proliferation and cytokine production, B and T cell cooperation, and antibody synthesis by B lymphocytes. No definitive benefits of interventions for enhancing the immune function, such as the use of intravenous immunoglobulin or myeloid colony-stimulating factors, have been demonstrated. Conclusion:As a consequence of the immaturity of several immune components, extremely preterm infants are highly susceptible to nosocomial infections. The very limited possibilities for intervention in this system require the control of extrinsic factors for the prevention of nosocomial sepsis in these infants. ResumoObjetivo: Realizar revisão sobre os principais aspectos do desenvolvimento imunológico fetal, salientando a defesa de prematuros extremos contra patógenos bacterianos e descrevendo a situação atual de intervenções imunoterapêuticas para a prevenção de sepse hospitalar. Fontes dos dados:Obtiveram-se, por meio de busca eletrônica, no banco de dados MEDLINE, artigos publicados nos últimos 15 anos referentes ao tema, e foram selecionados aqueles que trouxessem informações relevantes.Síntese dos dados: A imunidade de prematuros extremos é deficiente devido à fragilidade da pele, à carência dos produtos de ativação do sistema complemento, ao menor pool de reserva de precursores de neutrófilos na medula óssea e à quimiotaxia, aderência, deformabilidade e atividade enzimática neutrofílicas reduzidas. Limitações adicionais são detectadas na citotoxicidade de células NK, na proliferação e produção de citocinas dos linfócitos T, na cooperação entre células T e B e na síntese de anticorpos pelos linfócitos B. Ainda não foram demonstrados benefícios definitivos de intervenções para incremento da função imunológica dessas crianças, tais como o uso de imunoglobulinas endovenosas e de fatores estimuladores de colônias mielóides.Conclusão: Em conseqüência à imaturidade de diversos componentes da imunidade, prematuros extremos são altamente suscetíveis a infecções nosocomiais. As possibilidades ainda muito limitadas para a intervenção nesse sistema fazem com que...

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Localization of three subtypes of Fcγ receptors in human placenta by immunohistochemical analysis

Cited by 69 publications

References 13 publications

Placental transfer of naturally acquired, maternal cytomegalovirus antibodies in term and preterm neonates

Placental transfer of naturally acquired, maternal cytomegalovirus antibodies in term and preterm neonates

Expression of placental alkaline phosphatase does not correlate with IgG binding, internalization and transcytosis

Immunological peculiarities of extremely preterm infants: a challenge for the prevention of nosocomial sepsis

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