Localization of the Sentinel Node in Breast Cancer: Identical Results With Same-Day and Day-Before Isotope Injection

Abstract

The results of SLN mapping with same-day and day-before injection of radioisotope are virtually identical. The logistical advantages of day-before injection do not compromise the success of the procedure.

Tracer agents for the detection of sentinel lymph nodes in breast cancer: Current concerns and directions for the future

“…On the other hand, day-before injection allows greater flexibility in the scheduling of the radioisotope injection and the timing of surgery. Comparisons of same-day versus day-before injections found no significant difference in the sentinel node identification and false-negative rates [29]. Alternatively, Vargas et al [30] demonstrated that intraoperative injection of radioisotope is both technically feasible and effective for sentinel node localization.…”

Comparison of subareolar injection lymphoscintigraphy with the 1-day and the 2-day protocols for the detection of sentinel lymph nodes in patients with breast cancer

“…Because of time constraints the coordination of lymphoscintigraphy with surgery may be difficult to achieve [15][16][17][18]. The results of this study showed that there was a high-identification rate of sentinel lymph nodes, 91.1% by lymphoscintigraphy and 89.7% by gamma probe with the 1 day protocol.…”

Lymphatic Mapping Techniques and Sentinel Lymph Node Biopsy in Breast Cancer

“…Additionally, mapping was improved when 1.0 mCi-filtered radioisotope was used (versus 0.5 to 1.0 mCi unfiltered radioisotope). McCarter and colleagues [41] also had successful outcomes using the 2-day procedure. The authors studied 933 patients who received 0.1 mCi of dermal technitium-99 sulfur colloid in 0.05 cc normal saline on the day of surgery, and 387 patients who received 0.5 mCi technitium-99 sulfur colloid dermal injections on the day before operation.…”