Localization of the Renin-Angiotensin System in the Bovine Ovary: Cyclic Variation of the Angiotensin II Receptor Expression1

Schauser, Kirsten; Nielsen, A. H.; Winther, Henrik; Dantzer, V.; Poulsen, Knud

doi:10.1095/biolreprod65.6.1672

Cited by 27 publications

(31 citation statements)

References 36 publications

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“…In monovular species, the expression of AGTR2 receptor was first identified in theca cells from bovine dominant follicles (Schauser et al 2001). These data were further confirmed by Berisha et al (2002) who demonstrated mRNA-encoding AGTR1 and AGTR2 receptors in both theca and granulosa cells from bovine and observed a slight increase in AGTR2 mRNA in theca cells from highly estrogenic follicles (O180 ng/ml) in comparison with less estrogenic follicles (20-180 ng/ml).…”

Section: Ang II Receptors In Follicular Cellsmentioning

confidence: 56%

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Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Gonçalves¹,

Ferreira²,

Gasperin³

et al. 2012

Reproduction

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Angiotensin (Ang) II is widely known for its role in the control of systemic blood vessels. Moreover, Ang II acts on the vascular control of ovarian function, corpus luteum formation, and luteolysis. Over the past 10 years, our research group has been studying the new concept of the renin-angiotensin system (RAS) as an autocrine/paracrine factor regulating steroidogenesis and promoting different cellular responses in the ovary, beyond vascular function. We have developed and used different in vivo and in vitro experimental models to study the role of RAS in the ovary and a brief overview of our findings is presented here. It is widely accepted that there are marked species differences in RAS function in follicle development. Examples of species-specific functions of the RAS in the ovary include the involvement of Ang II in the regulation of follicle atresia in rats vs the requirement of this peptide for the dominant follicle development and ovulation in rabbits and cattle. More recently, Ang-(1-7), its receptor, and enzymes for its synthesis (ACE2, NEP, and PEP) were identified in bovine follicles, implying that Ang-(1-7) has an ovarian function. Other novel RAS components (e.g. (pro)renin receptor and renin-binding protein) recently identified in the bovine ovary show that ovarian RAS is poorly understood and more complex than previously thought. In the present review, we have highlighted the progress toward understanding the paracrine and autocrine control of ovarian antral follicle development and ovulation by ovarian tissue RAS, focusing on in vivo studies using cattle as a model.

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Section: Ang II Receptors In Follicular Cellsmentioning

confidence: 56%

“…Schauser et al (2001) observed intense AGTR2 receptor binding in cow periovulatory follicles, mainly in the theca cells. Using an in vivo model, our group demonstrated that i.m.…”

Section: Ang II Signaling and Receptors Near Ovulationmentioning

confidence: 82%

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Gonçalves¹,

Ferreira²,

Gasperin³

et al. 2012

Reproduction

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“…The present study identified a discrete RAS within the ovarian stroma and its blood vessels, including renin gene expression, angiotensinogen and ANG II protein and ACE binding. Of particular importance when attributing a function to the stromal RAS, is the localisation of AT 1a receptor mRNA to the stroma adjacent to large follicles and corpora lutea, a finding previously reported in the bovine ovary (Schauser et al 2001). The AT 1a receptor is viewed to elicit most of the cell growth and angiogenic properties of ANG II (Chung et al 1998), and it is therefore likely that ANG II at this site influences processes such as blood flow, vascularisation and growth of developing follicles via this receptor.…”

Section: Discussionmentioning

confidence: 72%

“…Previous studies in the rat have also reported angiotensin receptors to be absent in corpora lutea (Obermuller et al 1998), while other studies have reported angiotensin receptors in cultured luteal cells (Pepperell et al 1993) and renin mRNA in corpora lutea following gonadotrophin stimulation (Lightman et al 1987). In other species the results are also inconsistent with angiotensin receptors reported to be both present (Hayashi et al 2000, Schams et al 2003 and absent (Schauser et al 2001) in corpora lutea from cows and in low levels in pigs (Nielsen et al 1995). The reason for the discrepancies between the studies is unclear but may relate to species variations and/or modulation of the RAS by gonadotrophins at various stages of the oestrus cycle (Loret de Mola et al 1999).…”

Section: Figurementioning

confidence: 72%

Angiotensin II influences ovarian follicle development in the transgenic (mRen-2)27 and Sprague-Dawley rat

Gooyer¹,

Skinner²,

Wlodek³

et al. 2004

Journal of Endocrinology

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There is accumulating evidence that local reninangiotensin systems (RASs) influence cell growth and organ function in a variety of tissues including the ovary. The first aim of this study was to characterise the cellular location of RAS components in the rat ovary. This was facilitated by the use of the hypertensive transgenic (mRen-2)27 rat which overexpresses renin and angiotensin in extra-renal tissues. Comparisons were made with normal Sprague-Dawley (SD) rats. The second aim was to determine if the upregulated RAS of the transgenic (mRen-2)27 rat and infusion of angiotensin II (ANG II) in SD rats influences follicle number and litter size. Gene expression, immunohistochemical and autoradiographic techniques were used to identify a discrete RAS including ANG II receptors in the ovarian stroma, follicles (particularly atretic) and to a lesser extent corpora lutea. The RAS at these sites was most abundant in homozygous (HMZ) followed by heterozygous (HTZ) (mRen-2)27 rats and then SD rats. Large antral and preovulatory follicles and litter size were reduced in (mRen-2)27 rats. In HMZ (mRen-2)27 rats and SD rats infused with ANG II, angiotensin 1a (AT 1a ) receptor mRNA in the ovarian stroma was lower than control SD rats and was associated with a reduction in large antral and preovulatory follicles. These findings indicate that upregulation of the ovarian RAS in the rat influences follicular development and, potentially, reproductive capacity.

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“…In fact, the AngII receptor type 2 has been demonstrated to be the mediator of several reproductive functions including steroidogenesis, oocyte maturation, and ovulation (Kuji et al 1996, Ferreira et al 2007. In cows, the AngII receptor type 2 is present in the dominant follicle (Schauser et al 2001), and its mRNA expression was positively correlated with estradiol production (Portela et al 2006). In perfused rabbit ovaries, the ovulation and the meiosis resumption induced by hCG are blocked by saralasin (1-sarcosine-8-alanine-5-isoleucine-AngII, a competitive AngII antagonist; Yoshimura et al 1992).…”

Section: Introductionmentioning

confidence: 99%

Evidence that the effect of angiotensin II on bovine oocyte nuclear maturation is mediated by prostaglandins E2 and F2α

Barreta

Oliveira²,

Ferreira³

et al. 2008

Reproduction

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Angiotensin II (AngII) prevents the inhibitory effect of follicular cells on oocyte maturation, but its involvement in LH-induced meiotic resumption remains unknown. The aim of this study was to assess the involvement of AngII in LH-induced meiotic resumption and of prostaglandins (PGs) in the action of AngII. In the experiment I, seven cows were superovulated, intrafollicularly injected with 10 mM saralasin (a competitive AngII antagonist) or saline when the follicles reached a diameter larger than 12 mm, and challenged with a GnRH agonist to induce an LH surge. Fifteen hours after GnRH, the animals were ovariectomized and the oocytes were recovered to determine the stage of meiosis. The oocytes from follicles that received saline were in germinal vesicle (GV) breakdown (30.8%) or metaphase I (MI; 69.2%) stage while those that received saralasin were in the GV stage (100%; P!0.001) 15 h after GnRH agonist. In another experiment, oocytes were co-cultured with follicular hemisections for 15 h to determine whether PGs mediate the effect of AngII on meiotic resumption. Indomethacin (10 mM) inhibited AngII-induced meiotic resumption (13.4 vs 77.5% MI without indomethacin; P!0.001). Furthermore, the GV oocytes progressed to MI at a similar rate when PGE 2 , PGF 2a or AngII was present in the co-culture system with follicular cells (PGE 2 77.4%, PGF 2a 70.0%, and AngII 75.0% MI). In conclusion, our results provide strong evidence that AngII mediates the resumption of meiosis induced by an LH surge in bovine oocytes and that this event is dependent on PGE 2 or PGF 2a produced by follicular cells. Reproduction (2008) 136 733-740

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Localization of the Renin-Angiotensin System in the Bovine Ovary: Cyclic Variation of the Angiotensin II Receptor Expression1

Cited by 27 publications

References 36 publications

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances

Angiotensin II influences ovarian follicle development in the transgenic (mRen-2)27 and Sprague-Dawley rat

Evidence that the effect of angiotensin II on bovine oocyte nuclear maturation is mediated by prostaglandins E2 and F2α

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