Localization of the human urate oxidase gene (UOX) to 1p22

Yeldandi, Anjana V.; Patel, Yogesh; Liao, Martha; Kao, Fa‐Ten; RAO, MEGHA; Reddy, J. K.; Beau, Michelle M. Le

doi:10.1159/000133386

Cited by 26 publications

(10 citation statements)

References 5 publications

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“…Urate oxidase (UOX), which we have mapped to SSC 6, is localized on HSA lp22 (Yeldandi et al 1992). Five other loci (PGD, PRKACB, EN01 [Yerle et al 1995], ALPL and FUCA1 [Archibald et al 1995]), whose human homologs map to distal HSA lp, map to the long arm of SSC 6.…”

Section: Discussionmentioning

confidence: 88%

Assignment of 19 porcine type I loci by somatic cell hybrid analysis detects new regions of conserved synteny between human and pig

et al. 1996

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Nineteen so-called type I-loci, including ACO2, ADRA2, CAST, CCK, CHAT, IGKC, IGLV, IL4, IL6, INHA, LIF, MX1, PTH, RBP2, TCRA, TCRB, TGFB2, TGFB3, and UOX have been mapped in the pig with an informative somatic cell hybrid panel. By analyzing these new assignments in the knowledge of heterologous chromosome painting (Zoo-FISH) data for the porcine genome, it is possible to predict subchromosomal locations for most of these loci. Previously defined regions of conserved synteny were confirmed, and the extent of six of these regions was refined. These improvements in the porcine gene map facilitate the transfer of gene mapping data from "map-rich" species such as humans and mice.

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Section: Discussionmentioning

confidence: 88%

Assignment of 19 porcine type I loci by somatic cell hybrid analysis detects new regions of conserved synteny between human and pig

et al. 1996

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“…Allantoin is a product of the oxidation of uric acid by reactive oxygen species (ROS) in humans and hominoid primates [11]. However, allantoin is produced by two independent pathways in the mouse, one involving ROS and the other a reaction between uric acid and urate oxidase (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Critically, allantoin has been reported as a sensitive marker of oxidative stress [9,10]. In most mammals uric acid is converted to allantoin by urate oxidase; however, in humans the urate oxidase gene is not expressed due to several "nonsense" mutations and uric acid is converted to allantoin via reactive oxygen species as shown in Fig. (1) [9,11]. Taken together, allantoin could be a likely candidate biomarker of CD.…”

Section: Introductionmentioning

confidence: 99%

Allantoin as A Biomarker of Inflammation in an Inflammatory Bowel Disease Mouse Model: NMR Analysis of Urine

Dryland¹,

Love²,

Walker³

et al. 2008

Open Bioact Compd J

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Crohn's disease (CD) is an Inflammatory Bowel Disease (IBD) that is characterised by destructive inflammation of the intestinal wall. Current methods for determining inflammation of the bowel are costly, time consuming and can cause discomfort to the patients. In order to address these problems, biomarker analysis of more accessible tissues is receiving increasing attention. Oxidative stress has been implicated in the promotion of inflammation. Allantoin has recently been reported as a biomarker for oxidative stress in human serum and urine. This paper investigates allantoin as a biomarker of inflammation in a mouse model of CD. Proton nuclear magnetic resonance ( 1 H NMR) spectroscopy was used to analyse allantoin in urine from the mdr1a -/-mouse which is a model of CD. The data show that the levels of allantoin are strongly correlated with histological injury scores of mouse colonic tissue samples. Allantoin appears to be a useful biomarker of gut inflammation, involving oxidative stress, in a mouse model of CD and may be a potential biomarker in human CD studies.

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“…Most mammals degrade UA to allantoin (All) by urate oxidase. In humans, the expression of the gene for urate oxidase is abrogated by several mutations [2]. UA is a powerful antioxidant substance and it protects from lipoperoxidation.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of allantoin, hypoxanthine, xanthine, and uric acid in serum/plasma by CE

et al. 2007

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Allantoin (All) is an oxidative end product of purines in mammals. The small amount of All present in human plasma or serum results from free radical action on urate and may provide a stable marker of in vivo free radical activity. Because free radicals have been implicated in the development and progression of atherosclerosis, this study focused on the metabolic compounds of the All pathway. We propose a new fast CE (CE/UV) method for the simultaneous determination of All, uric acid (UA), hypoxanthine (HX), and xanthine (X) in human plasma. These products were quantified in the plasma of patients with chronic renal failure before hemodialysis (n = 6), patients with chronic heart failure (n = 6) and controls (n = 6). The filtered plasma were diluted ten-fold before the direct injection in CE/UV (195 nm), which allows separating the four compounds in less than 13 min. The metabolites were detectable at concentrations of 0.3-0.6 micromol/L. The method was linear over the range 0.5-150 micromol/L for All, HX, and X and 10-1500 micromol/L for UA (r > 0.99). The analytical performance of this method is satisfactory with intra-assay CV < 3.4%, inter-assay CV < 5% (HX and X < 7%), and recovery (93-101%). The proposed CE-UV method appears to be a useful tool for studying physiological and pathological changes of HX, UA, and All levels in plasma samples, the latter being a possible indicator of free radical damage in vivo.

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Localization of the human urate oxidase gene (UOX) to 1p22

Abstract: The human urate oxidase (E.C. 1.7.3.3) gene, UOX, is assigned to chromosome 1 by Southern analysis of human × hamster cell hybrids. Using fluorescent in situ hybridization, we have mapped this gene to 1p22.

Cited by 26 publications

References 5 publications

Assignment of 19 porcine type I loci by somatic cell hybrid analysis detects new regions of conserved synteny between human and pig

Assignment of 19 porcine type I loci by somatic cell hybrid analysis detects new regions of conserved synteny between human and pig

Allantoin as A Biomarker of Inflammation in an Inflammatory Bowel Disease Mouse Model: NMR Analysis of Urine

Simultaneous determination of allantoin, hypoxanthine, xanthine, and uric acid in serum/plasma by CE

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