Localization of the growth hormone receptor/binding protein in skin

Lobie, PE; Breipohl, W.; Lincoln, Doug; Garcia-Aragon, J.; Waters, M. J.

doi:10.1677/joe.0.1260467

Cited by 101 publications

(54 citation statements)

References 21 publications

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“…The presence of the GH receptor in human skin and its appendages, including eccrine sweat glands, suggests a direct effect of GH (10,11), but the exact mechanism by which GH exerts its effect is unknown. However, studies using PCR have shown an abundance of IGF-I receptor mRNA in human skin biopsies (20), which could suggest an IGF-I-mediated action on skin.…”

Section: Discussionmentioning

confidence: 99%

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Skin morphological changes in growth hormone deficiency and acromegaly

Lange

Thulesen

Feldt‐Rasmussen

et al. 2001

European Journal of Endocrinology

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Objective: To evaluate the histomorphology of skin and its appendages, especially eccrine sweat glands, in patients with GH disorders, because reduced sweating ability in patients with growth hormone de®ciency (GHD) is associated with increased risk of hyperthermia under stressed conditions. Design and methods: A skin biopsy was obtained from 17 patients with GHD treated with GH, ®ve patients with untreated GHD, 10 patients with active acromegaly and 13 healthy controls. Results: The sweat secretion rate (SSR) was signi®cantly decreased in both the untreated (median 41 mg/30 min, range 9±79 mg/30 min) and the GH-treated (median 98 mg/30 min, range 28± 147 mg/30 min) patients with GHD compared with that in controls (median 119 mg/30 min, range 90±189 mg/30 min; P 0X001 and 0.01 respectively). Epidermal thickness was signi®cantly decreased in both untreated (median 39 mm, range 28±55 mm) and GH-treated patients with GHD (median 53 mm, range 37±100 mm), compared with that in controls (median 66 mm, range 40± 111 mm; P , 0X02X A statistically non-signi®cant tendency towards thinner epidermis (median 59 mm, range 33±83 mm) was recorded in acromegalic patients P 0X08 compared with controls. There was no signi®cant difference in the area of the sebaceous glands in the biopsies between the three groups and the controls. The area of eccrine sweat gland glomeruli was signi®cantly decreased in the untreated patients with GHD (median 16407 mm 2 , range 12758±43976 mm 2 ) compared with that in controls (median 29446 mm 2 , range 13511±128661 mm 2 ; P 0X03Y but there was no signi®cant difference between the GH-treated patients with GHD and controls. Conclusions: We conclude that GH, either directly or via IGF-I, may have both a structural and a functional effect on human skin and its appendages, and that patients with GHD have histomorphological changes in skin compared with controls. Importantly, these changes are not fully reversed despite long-term and adequate GH treatment in patients with childhood onset GHD.

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Section: Discussionmentioning

confidence: 99%

“…It has been suggested that the effect on the skin and its appendages is in part a direct effect of GH (9). This suggestion is supported by identi®cation of the GH receptor in skin tissue, including the eccrine sweat glands (10,11).…”

Section: Introductionmentioning

confidence: 89%

Skin morphological changes in growth hormone deficiency and acromegaly

Lange

Thulesen

Feldt‐Rasmussen

et al. 2001

European Journal of Endocrinology

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“…The increased hair growth is observed in the facial and axillary regions, which may enhance masculine appearance and thereby enhance self-esteem. These effects on skin may be mediated directly at GHRs, since sweat glands in human skin and hair follicles in rat skin contain GHR immunoreactivity (Lobie et al 1990).…”

Section: Body Compositionmentioning

confidence: 99%

Growth hormone therapy and Quality of Life: possibilities, pitfalls and mechanisms

Hull

Harvey²

2003

Journal of Endocrinology

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The actions of growth hormone (GH) are not restricted to growth: GH modulates metabolic pathways as well as neural, reproductive, immune, cardiovascular, and pulmonary physiology. The importance of GH in most physiological systems suggests that GH deficiency at any age would be associated with significant morbidity. However, prior to the advent of recombinant GH, cadaverderived GH was only used therapeutically to correct the height deficit, and thereby hypothetically improve quality of life (QoL), in GH-deficient children. Physicians now have access to unlimited, albeit expensive, supplies of recombinant GH, and are considering the advisability of GH replacement or supplementation in other patient populations. This paper analyses studies investigating the relationship between GH and QoL in GH-deficient children or adults, in GH-replete short children suffering from idiopathic short stature, Turner syndrome, or intrauterine growth retardation and in GH-deficient or replete elderly adults. Possible mechanisms by which GH might improve QoL at neural and somatic sites are also proposed.

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“…Moreover, in a study performed on athletes, we showed that the water loss recorded during exercise was positively correlated with the GH secretion rate (14). In molecular research, speci®c receptors for GH have been found in the epithelium of sweat glands (15,16).…”

Section: Introductionmentioning

confidence: 99%

Effect of hydration on exercise-induced growth hormone response

Peyreigne¹,

Bouix²,

Fédou³

et al. 2001

European Journal of Endocrinology

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Design: Growth hormone (GH) has demonstrated water-retaining effects in subjects at rest, whereas other research has indicated that GH may stimulate sweating. Thus, the aim of this study was to investigate the effect of¯uid intake on the exercise-induced GH response. Methods: Seven healthy male volunteers (age: 27X4^1X3 years, weight: 74X5^1X1 kgY height: 179X32X3 cm performed a 40-min submaximal rectangular cycling exercise in two different sessions. The ®rst session (Session 1) was performed without water intake, and the second (Session 2) involved the ingestion of spring water (four intakes) corresponding to the volume of water lost during the ®rst session. Results: In session 1, the water loss was 568^32 mlX In Session 2, the volume of water loss was not signi®cantly different from the volume of¯uid intake 524^16 versus 568^32 ml respectively). The decrease in plasma volume was signi®cantly reduced in Session 2 26X69^1X59% versus 211X31 X89%; P , 0X05X In Session 1, the GH concentration was signi®cantly lower than that during Session 2 after 25 min 3X04^1X05 versus 5X26^1X81; P , 0X05 and after 40 min 13X7^3X55 versus 17X60^4X14 ngaml; P , 0X05 of exercise. The total GH response was signi®cantly lower in Session 1 than in Session 2 136X6^39X2 versus 202X4^58X9 ngamlXmin; P , 0X05X Conclusions: We conclude that the exercise-induced GH response decreases when exercise is performed without¯uid intake.

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Localization of the growth hormone receptor/binding protein in skin

Cited by 101 publications

References 21 publications

Skin morphological changes in growth hormone deficiency and acromegaly

Skin morphological changes in growth hormone deficiency and acromegaly

Growth hormone therapy and Quality of Life: possibilities, pitfalls and mechanisms

Effect of hydration on exercise-induced growth hormone response

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