Localization of Testicular Plasminogen Activator in Discrete Portions (Stages VII and VIII) of the Seminiferous Tubule

Lacroix, Martial; Parvinen, Martti; Fritz, Irving B.

doi:10.1095/biolreprod25.1.143

Cited by 120 publications

(34 citation statements)

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“…Such a metabolic influence has already been described for the carbohydrate metabolism of Sertoli cells (Jutte, 1982 (Parvinen etal., 1980 ;Purvis and Hansson, 1981). The same observation has been made in regard to plasminogen secretion both in vivo (Lacroix et al, 1981) and in vitro (Vihko et al, 1984 Gillet, 1984), and stabilized after this age.…”

supporting

confidence: 71%

Production of seminiferous and interstitial fluid in the growing rat after unilateral testicular irradiation

Laporte¹,

Floch²

1985

Reprod. Nutr. Dévelop.

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supporting

confidence: 71%

Production of seminiferous and interstitial fluid in the growing rat after unilateral testicular irradiation

Laporte¹,

Floch²

1985

Reprod. Nutr. Dévelop.

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“…2). It is therefore of interest that secretion by the Sertoli cell of a protease, plasminogen activator, is 10-to 30-fold higher at stages VII and VIII of the cycle than at other stages (Lacroix, Parvinen & Fritz, 1981). As it is known from studies in other tissues that secretion of plasminogen activator is correlated with cell migration and tissue restructuring (Beers, Strickland & Reich 1975;Strickland, Reich & Sherman, 1976), the implication is that plasminogen activator may be involved in the process of spermiation and/or the dissolution of tight junctions, particularly as these two events occur simultaneously (Russell, 1977).…”

Section: Control Of Germ Cell Divisionmentioning

confidence: 99%

Local Control of Testicular Function

Sharpe

1983

Exp Physiol

124

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This review has shown that local control of testicular function exists at three different levels. (1) Regulation of the entry of substances into the testis via the operation of selective barriers at the level of the capillary endothelium, myoid layer and Sertoli cell tight junctions, and by control of the rate of interstitial fluid formation which is the medium for transport into and within the testis. These mechanisms permit the creation of specific micro‐environments around the Leydig cells and outside of the seminiferous tubules as well as within the tubules, prerequisites for the local interaction and communication summarized below. (2) Regulation of spermatogenesis by co‐ordination of changes in hormone responsiveness and function of the Sertoli cells with the requirements of the associated germ cells, this varying according to the stage of the spermatogenic cycle. These changes involve regulation of germ cell multiplication, their differentiation and translocation from the basal to the adluminal compartment of the seminiferous tubule and their release into the lumen. (3) Interaction between the seminiferous tubules and the Leydig cells via various factors. The purpose of this interaction is not certain but in the prepubertal testis it probably co‐ordinates development of the tubules and Leydig cells, whilst in the adult testis it probably functions to regulate the steroidogenic responsiveness of the Leydig cells in accordance with the stage‐dependent requirements of the adjacent seminiferous tubules. Local control mechanisms within the testis therefore appear to co‐ordinate the function of the different cell types in the two testicular compartments and, as this is essential for normal function of the testis, the importance of local factors is self‐evident. In each of the three areas there is still only limited information as to the precise operation of the various mechanisms and even less is known about the identity of the co‐ordinating agents. But, as most of the available information derives only from the last three years, the gaps in our knowledge are to be expected and it is certain that the next few years will see major advances in this area. If the interpretation of the data offered in this review proves accurate then we are on the threshold of a revolution in our understanding of the control of testicular function, and of spermatogenesis in particular. This can only lead to improved methods for regulation of fertility in the male.

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“…The protease plasmin is formed from plasminogen in the extracellular space by the action of either of the two types of PA: tissue-type PA (tPA) and urokinase-type PA (uPA) that are secreted by a variety of cells in response to factors such as hormones, cytokines and growth factors [5,6]. Increasing evidence has also shown that the PA system is involved in the spermatogenesis process [7].…”

Section: Introductionmentioning

confidence: 99%

“…By histological exami nation of cross-sections of seminiferous tu bules, the cycle of spermatogenesis was di vided into 14 successive stages in the rat and 12 successive stages in the mouse [8], Initia tion of the complex restructuring process leading to the passage of meiosis-committed germ cells from the basal to the adluminal compartment and release of spermatozoa into the lumen (spermiation) both occur between stages VII and VIII. Segments of rat seminif erous tubules at stages VII and VIII secrete higher levels of PA compared to other stages [7,9]. In vitro, secretion of PA from Sertoli cells and segments of seminiferous tubules can be regulated by FSH and 8-bromo-cyclic AMP (dbcAMP) [10].…”

Section: Introductionmentioning

confidence: 99%

Hormonal Regulation of Plasminogen Activator in Rat and Mouse Seminiferous Epithelium

Liu¹,

Du²,

Liu³

et al. 1995

Neurosignals

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To elucidate the possible role of plasminogen activator (PA) in spermatogenesis and spermiation in mammals, we studied the hormonal regulation of PA secretion in cultured rat and mouse seminiferous tubules during defined stages of spermatogenesis. Results indicated that: (1) under basal conditions, segments of rat seminiferous tubules released primarily urokinase-type PA (uPA) at all stages of the cycle. The highest level of PA secretion occurred at stages VIIab, VIIcd and VIII. FSH, 8-bromo cyclic AMP and forskolin (FK) stimulated PA secretion, predominantly tissue-type PA (tPA). (2) In contrast, mouse seminiferous tubules secreted only tPA under basal conditions. In the presence of 50 µM MIX, seminiferous tubules at stages VII and VTII secreted higher levels of both types of PA than at the other stages. Both tPA and uPA secretion was enhanced by addition of FSH and FK to the organ culture media. (3) Segments of both rat and mouse seminiferous tubules at stages IX-XII in which the sperm residual bodies are absorbed into the Sertoli cells were also very sensitive to the addition of FSH to the organ culture. These results suggest that tPA in rat and mouse testes may play an essential role in the process of spermatogenesis and spermiation as well as in sperm residual body absorption.

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Localization of Testicular Plasminogen Activator in Discrete Portions (Stages VII and VIII) of the Seminiferous Tubule

Abstract: We have previously reported that rat Sertoli cells in culture produce and secrete plasminogen activator, a highly specific protease, and that FSH stimulates these processes.

Cited by 120 publications

References 0 publications

Production of seminiferous and interstitial fluid in the growing rat after unilateral testicular irradiation

Production of seminiferous and interstitial fluid in the growing rat after unilateral testicular irradiation

Local Control of Testicular Function

Hormonal Regulation of Plasminogen Activator in Rat and Mouse Seminiferous Epithelium

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