Localization of Steroidogenic Enzymes in Adrenal Cortex and Its Disorders.

Sasano, Hironobu

doi:10.1507/endocrj.41.471

Cited by 88 publications

(64 citation statements)

References 32 publications

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“…Histological study clearly demonstrated aldosteronoma associated with hyperplasia of non-neoplastic adrenal tissues. In particular, the immunoreactivity of 3β-HSD II was positive in the non-neoplastic tissues, which is in general not detected in primary aldosteronism (11,12 I mmu n o r e a c t i v i t y o f 3 β -HS D I I i n t h e h y p e r p l a st i c g l o me r u l o s a z o n e o f t h e n o n -n e o p l a s t i c a d r e n a l t i s s u …”

Section: D B Amentioning

confidence: 86%

Bilateral Aldosteronoma Associated with Secondary Aldosteronism in a Chronic Hemodialysis Subject

et al. 2010

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Section: D B Amentioning

confidence: 86%

Bilateral Aldosteronoma Associated with Secondary Aldosteronism in a Chronic Hemodialysis Subject

et al. 2010

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“…No hypercortisolemia was observed, although the present case had high levels of 17-OH progesterone, 17-OH pregnenolone and 11deoxycortisol, all precursors of cortisol. As shown in Tables 1a and 1b, not only estrogen but also other steroid hormones were elevated, indicating disorganized steroid hormone production in this tumor (18,19). Due to an incidentally low expression of CYPB11, we considered cortisol elevation to be absent.…”

Section: Discussionmentioning

confidence: 99%

Feminizing Adrenocortical Carcinoma with Selective Suppression of Follicle-Stimulating Hormone Secretion and Disorganized Steroidogenesis: A Case Report and Literature Review

et al. 2011

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We report a 61-year-old male with gynecomastia, poor libido and erectile dysfunction. Endocrinological studies showed high levels of estradiol and dehydroepiandrosterone sulfate. Although luteinizing hormone (LH) level was within the normal limit, the concentration of follicle-stimulating hormone (FSH) was under the normal limit. Delayed response of LH and poor response of FSH to gonadotropin-releasing hormone administration were detected. Magnetic resonance imaging of the abdomen revealed a left adrenal tumor. Although the surgically-resected tumor was diagnosed as a high grade ACC based on Weiss's criteria of adrenocortical malignancy, no metastasis was detected. Since estrogen levels normalized after resection, feminizing ACC was confirmed. While LH concentration increased slightly after operation, FSH level became transiently elevated over the normal limit, and finally reached the normal range. These data may suggest that FSH was suppressed selectively by hormone produced by ACC different from estrogen.

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“…The activities of 21-hydroxylase (P450c21), 17-hydroxylase (P450 17a), 11-hydroxylase (P45011p) and 18-hydroxylase were measured as described previously by the authors [9][10][11] in microsomal or mitochondrial fraction obtained from both tumours.…”

Section: Biochemical Activities Of Steroidogenic Enzymesmentioning

confidence: 99%

“…(P45011#), and DHEA-ST were performed with formalin-fixed, paraffin-embedded serial sections of the tumours by the biotin-strept-avidin amplified method and Histofine immunostaining system (Nichirei Co. Ltd., Tokyo, Japan). Immunostaining procedures and the characteristics of primary antibodies used in this study have been described previously by the authors [9,10]. Phosphate buffered saline (0.01 mol/1) and normal rabbit IgG were used instead of primary antibodies as negative controls.…”

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A Patient With Preclinical Cushing's Syndrome and Excessive DHEA-S Secretion Having Unilateral Adrenal Carcinoma and Contralateral Adenoma.

et al. 1999

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Abstract. We report a case of preclinical Cushing's syndrome in a 54-year-old male associated with bilateral adrenocortical tumours. Physical findings and general laboratory data were unremarkable except for mild hypertension (158/90 mmHg) and impaired glucose tolerance. Endocrinological evaluation revealed the presence of autonomous cortisol secretion including unsuppressible serum cortisol by 8 mg dexamethasone test (11,ug/dl), high serum DHEA-S (3580 ng/ml, normal: 400-3500) and increased urinary 17-KS excretion (31.0-35.8 mg/day, normal: 5.8-21.3). CT scan demonstrated the presence of tumours in both adrenals and bilateral adrenalectomy was subsequently performed. Histological examination of the resected specimens revealed an adrenocortical carcinoma on the right side and an adenoma on the left side with noticeable cortical atrophy in non-neoplastic adrenals. Immunohistochemical study of steroidogenic enzymes demonstrated that all the steroidogenic enzymes involved in cortisol biosynthesis were expressed in both right and left adrenal tumours. Enzymatic activities of 21, f3-hydroxylases were detected in both right and left adrenals except for the absence of 11 f3-hydroxylase activity in the left adrenal adenoma.Results of in vitro tissue steroidogenesis examined in short-term tissue culture of the specimens revealed no significant differences between carcinoma and adenoma in cortisol production, but the production of adrenal androgens in carcinoma was significantly higher than that in adenoma, which may indicate the importance of evaluating adrenal androgen levels in patients with adrenocortical neoplasms.

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Localization of Steroidogenic Enzymes in Adrenal Cortex and Its Disorders.

Cited by 88 publications

References 32 publications

Bilateral Aldosteronoma Associated with Secondary Aldosteronism in a Chronic Hemodialysis Subject

Bilateral Aldosteronoma Associated with Secondary Aldosteronism in a Chronic Hemodialysis Subject

Feminizing Adrenocortical Carcinoma with Selective Suppression of Follicle-Stimulating Hormone Secretion and Disorganized Steroidogenesis: A Case Report and Literature Review

A Patient With Preclinical Cushing's Syndrome and Excessive DHEA-S Secretion Having Unilateral Adrenal Carcinoma and Contralateral Adenoma.

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