Localization of serotonin and its possible role in early embryos of Tritonia diomedea (Mollusca: Nudibranchia)

Buznikov, G. A.; Nikitina, L. A.; Voronezhskaya, Elena E.; Безуглов, В. В.; Willows, A. O. D.; Nezlin, Leonid P.

doi:10.1007/s00441-002-0666-0

Cited by 36 publications

(21 citation statements)

References 33 publications

(32 reference statements)

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“…9 ([ 31 , 62 – 64 ], present data)), and in the hyposphere (caudally or caudo-laterally) in gastropods and polyplacophores (scenario 3 on Fig. 9 [ 57 , 65 , 66 ]). Important, the primary location of the sensory pioneer neurons in larvae is largely irrelevant, while the way of their neurites will ultimately mark a position of VNC, albeit through different pathways (dorso-ventral direction or posterior-anterior direction).…”

Section: Discussionmentioning

confidence: 83%

Nervous system development in the Pacific oyster, Crassostrea gigas (Mollusca: Bivalvia)

et al. 2018

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BackgroundBivalves comprise a large, highly diverse taxon of invertebrate species. Developmental studies of neurogenesis among species of Bivalvia are limited. Due to a lack of neurogenesis information, it is difficult to infer a ground pattern for Bivalvia. To provide more comprehensive morphogenetic data on bivalve molluscs and relationships among molluscan clades, we investigated neurogenesis in the Pacific oyster, Crassostrea gigas, from the appearance of the first sensory cells to the formation of the larval ganglionic nervous system by co-immunocytochemistry of the neuronal markers FMRFamide or 5-HT and vesicular acetylcholine transporter (VAChT).ResultsNeurogenesis begins with the emergence of the apical serotonin-immunoreactive (5-HT-ir) sensory cells and paired sensory posttrochal dorsal and ventral FMRFamide-immunoreactive (FMRFamide-ir) cells at the early trochophore stage. Later, at the early veliger stage, the apical organ (AO) includes 5-HT-ir, FMRFamide-ir, and VAChT-ir cells. At the same stage, VAChT-ir cells appear in the posterior region of larvae and send axons towards the AO. Thus, FMRFamide-ir neurites and VAChT-ir processes form scaffolds for longitudinal neurite bundles develop into the paired ventral nerve cords (VNC). Later-appearing axons from the AO/CG neurons join the neurite bundles comprising the VNC. All larval ganglia appear along the VNC as paired or fused (epiathroid) clusters in late veliger and pediveliger larvae. We observed the transformation of the AO into the cerebral ganglia, which abundantly innervated the velum, and the transformation of ventral neurons into the pedal ganglia, innervating the foot, gills, and anterior adductor muscle. The visceral ganglia appear last in the pediveliger oyster and innervate the visceral mass and posterior adductor of premetamorphic larvae. In addition, a local FMRFamide-ir network was detected in the digestive system of pediveliger larvae. We identified VAChT-ir nervous elements in oyster larvae, which have not been observed previously in molluscs. Finally, we performed a morphology-based comparative analysis of neuronal structures among bivalve, conchiferan, and aculiferan species.ConclusionsWe described the development of the nervous system during the larval development in Crassostrea gigas. These data greatly advance the currently limited understanding of neurodevelopment in bivalves and mollusks, which has hampered the generation of a ground pattern reconstruction of the last common ancestor of Mollusca. Our morphological data support phylogenomic data indicating a closer Bivalvia-Gastropoda sister group relationship than the Bivalvia-Scaphopoda (Diasoma) group relationship.Electronic supplementary materialThe online version of this article (10.1186/s12983-018-0259-8) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 83%

Nervous system development in the Pacific oyster, Crassostrea gigas (Mollusca: Bivalvia)

et al. 2018

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“…Serotonin is present in all species of early embryos studied (Buznikov, 1989). In particular in sea urchins it is distributed over the cytoplasm (Buznikov et al , 1979; Markova et al , 1985; Buznikov et al , 2003; Amireault & Dubé, 2005). The present immunohistochemical research showed the uniform localization of serotonin.…”

Section: Discussionmentioning

confidence: 99%

Expression and functional activity of neurotransmitter system components in sea urchins’ early development

Никишин

Milošević²,

Gojković³

et al. 2015

Zygote

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Reverse-transcription polymerase chain reaction (RT-PCR) investigation of the expression of the components supposedly taking part in serotonin regulation of the early development of Paracentrotus lividus has shown the presence of transcripts of five receptors, one of which has conservative amino acid residues characteristic of monoaminergic receptors. At the early stages of embryogenesis the expressions of serotonin transporter (SERT) and noradrenaline transporter (NET) were also recognized. The activities of the enzymes of serotonin synthesis and serotonin transporter were shown using immunohistochemistry and incubation with para-chlorophenylalanine (PСРА) and 5-hydroxytryptophan (HTP). Pharmacological experiments have shown a preferential cytostatic activity of ligands characterized as mammalian 5-hydroxytryptamine (5-HT)1-antagonists. On the basis of the sum of the data from molecular biology and embryo physiological experiments, it is suggested that metabotropic serotonin receptors and membrane transporters take part in the regulatory processes of early sea urchin embryogenesis.

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“…Detailed results from Buznikov's and other laboratories provided pharmacological and immunocytochemical evidence in developing embryos and larvae from sea urchin species of a pre-nervous serotoninergic system, a multifunctional regulator of key events in early embryogenesis, whose action is mediated by 5-HT receptors or transporters (Renaud et al 1983;Buznikov et al 1996Buznikov et al , 2001Buznikov et al , 2005Yaguchi et al 2000;Katow et al 2004). Similar data were obtained in other invertebrate species, and this neurochemical has been shown to participate in the control of oocyte maturation (Krantic et al 1993;Leclerc et al 2000;Stricker & Smythe 2000) and fertilization (Leclerc et al 2000), and to act as a regulator of cleavage division (Buznikov et al 2003) and of cell movement during gastrulation (Colas et al 1999a, b). The ability of neurotransmitters to regulate basic developmental processes before the appearance of neurons seems to be conserved across animal taxa.…”

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confidence: 77%

Distribution of cells containing FMRFamide‐related molecules in the embryonic development of Ophryotrocha labronica (Polychaeta: Dorvilleidae)

Franchini

2008

Invertebrate Biology

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Abstract. The timing and spatial distribution of cells containing FMRFamide‐related molecules in the embryogenesis of the polychaete Ophryotrocha labronica were studied immunocytochemically. FMRFamide‐like molecules emerge early during embryonic development. They are found at the one‐cell stage, are asymmetrically distributed in the first phases of cleavage, associated with gastrular movements, and label the central nervous system morphogenesis. Moreover, during embryogenesis, the pattern of gut cells with the FMRFamide‐like phenotype that is present in adults is already established. The early occurrence of FMRFamide‐like molecules in O. labronica suggests that these molecules are involved as pre‐nervous growth signals in the regulation of basic neuronal cell behaviors.

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Localization of serotonin and its possible role in early embryos of Tritonia diomedea (Mollusca: Nudibranchia)

Cited by 36 publications

References 33 publications

Nervous system development in the Pacific oyster, Crassostrea gigas (Mollusca: Bivalvia)

Nervous system development in the Pacific oyster, Crassostrea gigas (Mollusca: Bivalvia)

Expression and functional activity of neurotransmitter system components in sea urchins’ early development

Distribution of cells containing FMRFamide‐related molecules in the embryonic development of Ophryotrocha labronica (Polychaeta: Dorvilleidae)

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