Localization of Secretory Granule Marker Protein Chromogranin B in the Nucleus

Yoo, Seung Hyun; You, Soon Hee; Kang, Moon Kyung; Huh, Yang Hoon; Shim, Chan Seob

doi:10.1111/j.1749-6632.2002.tb04492.x

Cited by 15 publications

(32 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tweety1 and Hes6 were identified as common gene targets for Neurog3 and NeuroD1 and chromogranin B was identified as a Neurog3‐specific target. While we do not know the relevance of the specific induction of chromogranin B mRNA by Neurog3, it is noteworthy that this Ca 2+ storage protein of the secretory granules of neuroendocrine cells has also been detected in the cell nucleus where it may impact transcription (Yoo et al, 2002).…”

Section: Resultsmentioning

confidence: 93%

Induction of pancreatic islet cell differentiation by the neurogenin–neuroD cascade

et al. 2008

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 93%

Induction of pancreatic islet cell differentiation by the neurogenin–neuroD cascade

et al. 2008

View full text Add to dashboard Cite

“…The total calcium content of the nucleus is very high, above 10 mmole/l, the second highest after the secretory granules [82]. The high capacity/low affinity Ca 2+ binding proteins chromogranin and secretogranin are present in large NucCaSig4.doc_Alonso&Garcia-Sancho 10 amounts in the nucleus [114,115], but, surprisingly, they apparently do not overlap with NE nor nucleoplasmic reticulum membranes. Apparently chromogranin B, phospholipid and IP 3 R colocalize in complexes of 2-3•10 7 Da [116] not associated to morphologic differentiations.…”

Section: Unconventional Nuclear Discharge Docks: Nucleoplasmic Reticumentioning

confidence: 96%

Nuclear Ca2+ signalling

Alonso

García‐Sancho

2011

Cell Calcium

View full text Add to dashboard Cite

Ca(2+) signalling is important for controlling gene transcription. Changes of the cytosolic Ca(2+) ([Ca(2+)](C)) may promote migration of transcription factors or transcriptional regulators to the nucleus. Changes of the nucleoplasmic Ca(2+) ([Ca(2+)](N)) can also regulate directly gene expression. [Ca(2+)](N) may change by propagation of [Ca(2+)](C) changes through the nuclear envelope or by direct release of Ca(2+) inside the nucleus. In the last case nuclear and cytosolic signalling can be dissociated. Phosphatidylinositol bisphosphate, phospholipase C and cyclic ADP-ribosyl cyclase are present inside the nucleus. Inositol trisphosphate receptors (IP(3)R) and ryanodine receptors (RyR) have also been found in the nucleus and can be activated by agonists. Furthermore, nuclear location of the synthesizing enzymes and receptors may be atypical, not associated to the nuclear envelope or other membranes. The possible role of nuclear subdomains such as speckles, nucleoplasmic reticulum, multi-macromolecular complexes and nuclear nanovesicles is discussed.

show abstract

“…This allows CGB to start aggregation at lower (micromolar) calcium concentration (Yoo,1995). In addition, CGB also localizes to the nucleus in bovine chromaffin cells, where it is believed to participate to transcription control (Yoo et al,2002). As a result, it appears that the biosynthesis of CGA and CGB in CV is independently regulated.…”

Section: Graninsmentioning

confidence: 99%

The Chromaffin Vesicle: Advances in Understanding the Composition of a Versatile, Multifunctional Secretory Organelle

Crivellato

Nico

2008

The Anatomical Record

View full text Add to dashboard Cite

Chromaffin vesicles (CV) are highly sophisticated secretory organelles synthesized in adrenal medullary chromaffin cells. They contain a complex mixture of structural proteins, catecholamine neurotransmitters, peptide hormones, and the relative processing enzymes, as well as protease inhibitors. In addition, CV store ATP, ascorbic acid, and calcium. During the last decades, extensive studies have contributed to increase our understanding of the molecular composition of CV. Yet, the recent development of biochemical and imaging procedures has greatly increased the list of CV-soluble constituents and opened new horizons as to the complexity of CV involvement in acute stress responses. Thus, a coherent picture of CV molecular composition is still to be drawn. This review article will provide a detailed account of the content of CV soluble molecules as it emerges from the most recent analytical studies. Moreover, this review article will attempt at focussing on the physiological and pathophysiological implications of the products released by CV.

show abstract

Localization of Secretory Granule Marker Protein Chromogranin B in the Nucleus

Cited by 15 publications

References 0 publications

Induction of pancreatic islet cell differentiation by the neurogenin–neuroD cascade

Induction of pancreatic islet cell differentiation by the neurogenin–neuroD cascade

Nuclear Ca2+ signalling

The Chromaffin Vesicle: Advances in Understanding the Composition of a Versatile, Multifunctional Secretory Organelle

Contact Info

Product

Resources

About