Localization of Rolling and Firm-Adhesive Interactions Between Circulating Tumor Cells and the Microvasculature Wall

Dabagh, Mahsa; Gounley, John; Randles, Amanda

doi:10.1007/s12195-020-00610-7

Cited by 17 publications

(12 citation statements)

References 49 publications

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“…The mechanisms through which arrested cancer cells come out of the vessels in anatomic sites close to or distant from the primary tumor are very similar to those employed by neutrophils or monocytes to exit from vessels during inflammation [ 98 ]. At the beginning, entrapped tumor cells slide toward the margins of the blood or lymph stream; then, they bind with low affinity to selectins, i.e., adhesion receptors expressed on the endothelial cell membrane [ 103 ]. This is because carcinoma cells express selectin ligands such as CD24, CD44 or the carcinoembryonic antigen ( Table 1 ) [ 75 , 76 , 78 ].…”

Section: Mmp-9 Aids Cancer Cell Trafficking Inside and Outside Thementioning

confidence: 99%

The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process

Barillari

2020

IJMS

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In industrialized countries, cancer is the second leading cause of death after cardiovascular disease. Most cancer patients die because of metastases, which consist of the self-transplantation of malignant cells in anatomical sites other than the one from where the tumor arose. Disseminated cancer cells retain the phenotypic features of the primary tumor, and display very poor differentiation indices and functional regulation. Upon arrival at the target organ, they replace preexisting, normal cells, thereby permanently compromising the patient’s health; the metastasis can, in turn, metastasize. The spread of cancer cells implies the degradation of the extracellular matrix by a variety of enzymes, among which the matrix metalloproteinase (MMP)-9 is particularly effective. This article reviews the available published literature concerning the important role that MMP-9 has in the metastatic process. Additionally, information is provided on therapeutic approaches aimed at counteracting, or even preventing, the development of metastasis via the use of MMP-9 antagonists.

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Section: Mmp-9 Aids Cancer Cell Trafficking Inside and Outside Thementioning

confidence: 99%

The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process

Barillari

2020

IJMS

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“…A conclusion is drawn that the CTC adhesion becomes weak as the shear rate increases, which was also confirmed in the recent simulation work of Dabagh et al . [ 26 ]. For example, at about , there are 13, 6 and 3 bonds formed for , 0.095 and 0.19, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…However, some experiments [ 23 – 25 ] have shown that the soft CTCs are more likely to extravasate from the circulation, because the soft CTCs have a large contact surface with the vascular wall and thus have a higher possibility of adhesion than the rigid CTCs. Recently, some simulation work [ 26 , 27 ] has also favored the latter conclusion.…”

Section: Introductionmentioning

confidence: 93%

“…[ 51 ] observed that the diameter of a tumor cell in vivo is only about 5 μ m, while Guo et al . [ 34 ] gave its diameter about 16 μ m. In simulations, a moderate value of 8–10 μ m is often chosen for saving computational cost [ 26 , 27 , 52 ]. The CTC’s nucleus is also neglected for the same purpose, saving the computational cost, and this is one of limitations of our cell model.…”

Section: Introductionmentioning

confidence: 99%

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Margination and adhesion dynamics of tumor cells in a real microvascular network

Wang

et al. 2021

PLoS Comput Biol

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In tumor metastasis, the margination and adhesion of tumor cells are two critical and closely related steps, which may determine the destination where the tumor cells extravasate to. We performed a direct three-dimensional simulation on the behaviors of the tumor cells in a real microvascular network, by a hybrid method of the smoothed dissipative particle dynamics and immersed boundary method (SDPD-IBM). The tumor cells are found to adhere at the microvascular bifurcations more frequently, and there is a positive correlation between the adhesion of the tumor cells and the wall-directed force from the surrounding red blood cells (RBCs). The larger the wall-directed force is, the closer the tumor cells are marginated towards the wall, and the higher the probability of adhesion behavior happen is. A relatively low or high hematocrit can help to prevent the adhesion of tumor cells, and similarly, increasing the shear rate of blood flow can serve the same purpose. These results suggest that the tumor cells may be more likely to extravasate at the microvascular bifurcations if the blood flow is slow and the hematocrit is moderate.

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“…The transport of cells in the human body is the main mechanism to sustain life as it provides oxygen, nutrient, and defensive mechanism to fence off infection. Human cells are comprised of many compartments such as bi-lipid membrane, cytoplasm, nucleus, and others [2]. However, special cells such as the Red Blood Cell (RBC), White Blood Cell (WBC), and platelet, are contained mostly of a thin membrane and cytosol fluid [3].…”

Section: Introductionmentioning

confidence: 99%

A Hybrid Continuum-Particle Approach for Fluid-Structure Interaction Simulation of Red Blood Cells in Fluid Flows

Akerkouch

2021

Fluids

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Transport of cells in fluid flow plays a critical role in many physiological processes of the human body. Recent developments of in vitro techniques have enabled the understanding of cellular dynamics in laboratory conditions. However, it is challenging to obtain precise characteristics of cellular dynamics using experimental method alone, especially under in vivo conditions. This challenge motivates new developments of computational methods to provide complementary data that experimental techniques are not able to provide. Since there exists a large disparity in spatial and temporal scales in this problem, which requires a large number of cells to be simulated, it is highly desirable to develop an efficient numerical method for the interaction of cells and fluid flows. In this work, a new Fluid-Structure Interaction formulation is proposed based on the use of hybrid continuum-particle approach, which can resolve local dynamics of cells while providing large-scale flow patterns in the vascular vessel. Here, the Dissipative Particle Dynamics (DPD) model for the cellular membrane is used in conjunction with the Immersed Boundary Method (IBM) for the fluid plasma. Our results show that the new formulation is highly efficient in computing the deformation of cells within fluid flow while satisfying the incompressibility constraints of the fluid. We demonstrate that it is possible to couple the DPD with the IBM to simulate the complex dynamics of Red Blood Cells (RBC) such as parachuting. Our key observation is that the proposed coupling enables the simulation of RBC dynamics in realistic arterioles while ensuring the incompressibility constraint for fluid plasma. Therefore, the proposed method allows an accurate estimation of fluid shear stresses on the surface of simulated RBC. Our results suggest that this hybrid methodology can be extended for a variety of cells in physiological conditions.

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Localization of Rolling and Firm-Adhesive Interactions Between Circulating Tumor Cells and the Microvasculature Wall

Cited by 17 publications

References 49 publications

The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process

The Impact of Matrix Metalloproteinase-9 on the Sequential Steps of the Metastatic Process

Margination and adhesion dynamics of tumor cells in a real microvascular network

A Hybrid Continuum-Particle Approach for Fluid-Structure Interaction Simulation of Red Blood Cells in Fluid Flows

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