Localization of renal oxidative stress and inflammatory response after lithotripsy

Clark, Daniel; Connors, Bret A.; Evan, Andrew P.; Willis, Lynn R.; Handa, Rajash K.; Gao, Sujuan

doi:10.1111/j.1464-410x.2008.08260.x

Cited by 31 publications

(49 citation statements)

References 28 publications

(40 reference statements)

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“…Aksoy et al [5] reported an increase in MDA and nitric oxide in plasma and urine immediately after a shockwave session. However, as in the present study, neither a study by Clark et al [33] nor a previous study [34] found changes in LPO levels. For oxidative stress in the present study, there were only slight decreases in GSH and SOD at the 2-and 24-h follow-ups.…”

Section: Eswl Associated Injurycontrasting

confidence: 87%

The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

et al. 2014

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These results are protected by a patent at the Spanish Office of Patents and Trademarks (Reference: P201131992) Objective• To determine the efficacy of coenzyme Q10 (CoQ10) in preventing renal injury in patients with lithiasis undergoing extracorporeal shockwave lithotripsy (ESWL). Patients and Methods• Prospective, randomised, double-blind, placebo-controlled clinical trial of 100 patients with renal lithiasis who were treated with ESWL.• The patients were distributed randomly into two groups receiving either placebo or CoQ10 (200 mg/day), a powerful antioxidant with vasoactive properties, orally administered during the week before ESWL and for 1 week after.• Renal dysfunction markers, vasoactive hormones, oxidative stress, plasma levels of several interleukins and vascular resistance index (VRI) using Doppler ultrasound were evaluated the week before ESWL, 2 h before ESWL and at 2 h, 24 h and 7 days after ESWL. Results• There was a significant increase in glomerular filtration (P = 0.013), as well as a decrease in the albumin/creatinine ratio and the β2-microglobulin level (P = 0.02) after 1 week of treatment in the CoQ10 group. These changes were maintained at the follow-up after ESWL.• The administration of CoQ10 was associated with improvement in vasoactive hormone parameters, VRI and interleukin levels. These improvements were maintained until the end of the follow-up period.• However, the administration of CoQ10 was not associated with significant changes in the oxidative stress parameters. Conclusion• Our results indicate that CoQ10 administration improves renal function and vasoactive and inflammation parameter values, allowing for preconditioning before the tissue insult caused by ESWL.

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Section: Eswl Associated Injurycontrasting

confidence: 87%

The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

et al. 2014

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“…While earlier studies focused on oxidative injury to the renal cortex (15), Clark et al showed that acute oxidative stress and infl ammation after SWL are highly localized to the renal medulla within the focus (F2) of the lithotripter (19). In our study we also observed that cortical and medullar collector tubules were more affected than glomeruli.…”

Section: Discussionsupporting

confidence: 63%

Reduction of shock wave lithotripsy-induced renal tubular injury by tadalafil

Me¹,

Aytaç²,

Kilicaslan³

et al. 2013

BLL

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Abstract:Objectives: The aim of the study was to examine whether administration of tadalafi l, a phosphodiesterase type 5 inhibitor, has a protective effect in the prevention of renal injury in a rat model after Shock Wave Lithotripsy (SWL), with the assessment based on histopathologic examination and measurement of Heat Shock Protein 70 expression. Methods: A total of 40 adult, male Sprague-Dawley rats were divided into fi ve groups as follows; control group, group SN3, group SN7, group TSN3, TSN7. Both kidneys were evaluated regarding tubular damage, peritubular fi brosis and glomerular damage using light microscopy. We examined HSP-70 expression, which occurred in response to renal ischemic injury observed after SWL. The groups were compared between each other and with the control group. Results: No statistically signifi cant difference was found when the groups were compared using light microscopy for the changes in glomeruli. Tubular necrosis, loss of microvilli and peritubular fi brosis were less in Group TSN3 and Group TSN7 compared to Group SN3. Similarly, tubular necrosis, loss of microvilli and peritubular fi brosis were less in Group TSN3 and Group TSN7 compared to Group SN7. HSP-70 staining was less in Group TSN3 and Group TSN7 compared to Group SN3 and Group SN7. Conclusion: Based on the results of light microscopy and HSP-70 staining, we demonstrated that SWL could cause renal ischemia-reperfusion injury. Our results suggested that Tadalafi l administration could prevent this SWL-related renal cell injury (Tab. 2, Fig. 5, Ref. 28). Text in PDF www.elis.sk.

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“…The role of these signaling molecules is communication between immune cells or other cells. They regulate inflammatory and immune responses (14). Interleukin-1ɑ (IL-1ɑ) and interleukin-6 (IL-6) are used to call pro-inflammatory cytokines due to their role in the inflammatory process.…”

Section: Introductionmentioning

confidence: 99%

Urinary level of interleukin-1alpha and interleukin-6 in patients underwent extracorporeal shock wave lithotripsy

Chenari¹,

Fazeli²,

Jahantigh³

et al. 2017

J Renal Inj Prev

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Findings of the current study highlighted the underlying inflammatory process following extracorporeal shock wave lithotripsy (ESWL) procedure and can be a good sample for further investigations. Introduction: Extracorporeal shock wave lithotripsy (ESWL) was established as a dramatic procedure in the treatment of urinary stones. According to the growing utilization of ESWL as a major method of urinary stone, management and the reports have been reported based on renal tissue damage. Objectives: We decided to examine the severity of ESWL-induced renal tissue damage and its related factors by monitoring the urinary levels of cytokines. Patients and Methods: In this study, the urinary samples of 32 patients with urolithiasis were taken before, 24 hours and 14 days after ESWL and interleukin-1ɑ (IL-1a) and interleukin-6 (IL-6) levels were measured by enzyme-linked immunosorbent assay (ELISA) method. Results: Our findings indicated that there was a significant difference between the urinary levels of both IL-1ɑ and IL-6 in 14 days before and after ESWL. Conclusion: According to our results, ESWL leads to an inflammatory process in the urinary tract and the inflammation have continuously increased up to 14 days after procedure. Please cite this paper as:

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Localization of renal oxidative stress and inflammatory response after lithotripsy

Cited by 31 publications

References 28 publications

The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

Reduction of shock wave lithotripsy-induced renal tubular injury by tadalafil

Urinary level of interleukin-1alpha and interleukin-6 in patients underwent extracorporeal shock wave lithotripsy

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