Localization of pancreatic endocrine tumours

Hammond, P. J.; Jackson, J. A.; Bloom, Stephen R.

doi:10.1111/j.1365-2265.1994.tb02436.x

Cited by 41 publications

(16 citation statements)

References 67 publications

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“…Although many diagnostic tools are available, including abdominal ultrasound, CT scan, endoscopic retrograde cholangiopancreatography (ERCP), echoendoscopy, and percutaneous transhepatic cholangiography (PTC), the correct diagnosis of endocrine tumor is usually made postoperatively after histological and immunohistochemical examination of the surgical specimen [14,23,25].…”

Section: Discussionmentioning

confidence: 99%

Well-differentiated endocrine tumor of the distal common bile duct: a case study and literature review

et al. 2006

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Primary carcinoid tumors of the extrahepatic biliary tree are exceedingly rare, accounting for 0.2-2% of all digestive carcinoids. The authors in this study describe a case of biliary duct primary well-differentiated endocrine tumor in a 30-year-old man with symptoms of biliary obstruction and watery diarrhoea. Abdominal ultrasound showed a 2-cm solid lesion in the head of the pancreas, compressing the distal common bile duct. A computed tomography scan confirmed these findings, revealing the hypervascular pattern of the tumor. Gastrointestinal hormonal screening demonstrated an increase in plasma serotonin. The patient underwent standard pylorus-preserving pancreatoduodenectomy. Pathological examination showed a neuroendocrine tumor of the distal common bile duct measuring 1.8 cm in greatest dimension. The tumor cells were immunopositive for neuron-specific enolase (NSE), chromogranin A, synaptophysin, serotonin, and cytokeratin. Stains for gastrin and somatostatin were negative. Seven years later, the patient is well, with no evidence of disease. Given the site of these tumors and the difficulty in differentiating them from periampullary lesions, decisions as to the appropriate surgical approach may be problematic. After an exhaustive review of the literature, the authors conclude that pancreatoduodenectomy is the treatment of choice.

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Section: Discussionmentioning

confidence: 99%

Well-differentiated endocrine tumor of the distal common bile duct: a case study and literature review

et al. 2006

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“…The detection of the tumor by arteriography depends on both tumor vascularity and tumor size. Arteriography may therefore be a useful localization procedure in selected patients 12 but is used infrequently today in our medical center for this purpose. The sensitivity of arteriography for detection of tumors less than 1 cm in diameter among our patients in this series was 71%.…”

Section: Commentmentioning

confidence: 99%

Localization of Insulinomas

et al. 1999

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“…After the injection of calcium into the splenic artery (SA), gastroduodenal artery (GDA), superior mesenteric artery (SMA), and proper hepatic artery (PHA), hepatic venous blood was sampled and serum immunoreactive insulin (IRI) levels were measured. The IRI levels were markedly increased after the injection of calcium into the SA and GDA [1][2][3][4] The reliability of PTPS is also unsatisfactory in patients with multiple tumors despite the fact that it has been reported to be highly sensitive in regionalizing the tumor to the head-uncinate or body-tail regions. 6 The failure of accurately localizing tumors results in the need for reoperation.…”

Section: Discussionmentioning

confidence: 95%

Combining the selective arterial calcium injection test and intraoperative blood glucose monitoring for multiple insulinomas: Report of two cases

et al. 2000

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To date, no precise methods of preoperatively localizing multiple insulinomas or intraoperatively confirming their complete removal have been established. We describe herein the effectiveness of combining the selective arterial calcium injection (SACI) test to locate tumors preoperatively, with intraoperative continuous blood glucose monitoring (IOBGM) to confirm their complete removal. During the 8-year period from 1990 to 1997, we experienced two patients with multiple insulinomas. The first patient required resection of a residual tumor in the remnant pancreas for persistent hyperinsulinemia after a distal pancreatectomy performed under conventional diagnostic procedures. In the second patient, a SACI test was performed in addition to other diagnostic imaging procedures, and while computed tomography scan, endoscopic ultrasonography, and arteriography demonstrated multiple tumors in the body and tail of pancreas, the SACI test suggested that there were also tumors in the head of pancreas. Intraoperative ultrasonography showed a tumor measuring 5 mm in diameter on the surface of the head of the pancreas, apart from the multiple tumors in the body and tail of the pancreas. Complete removal of all tumors was assessed by the hyperglycemic rebound after resection of the tumors, determined by IOBGM. Based upon our experience, we believe that the SACI test and IOBGM are helpful for establishing precise localization and achieving complete removal of multiple insulinomas.

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Localization of pancreatic endocrine tumours

Cited by 41 publications

References 67 publications

Well-differentiated endocrine tumor of the distal common bile duct: a case study and literature review

Well-differentiated endocrine tumor of the distal common bile duct: a case study and literature review

Localization of Insulinomas

Combining the selective arterial calcium injection test and intraoperative blood glucose monitoring for multiple insulinomas: Report of two cases

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