Localization of neurones projecting to the hypothalamic paraventricular nucleus area of the rat: A horseradish peroxidase study

Tribollet, Eliane; Dreifuss, Jean Jacques

doi:10.1016/0306-4522(81)90190-1

Cited by 207 publications

(105 citation statements)

References 46 publications

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“…As OT has a facilitatory role in oxytocinergic neurons in PVN, 71,72 we suggest that the stimulation of PVN OT receptors by OT facilitate the induction of grooming behavior 73 and might induce a subsequently neurotransmission release of OT in the CeA. As CeA sends projections to PVN, 37 activation of the CeA OT receptors by OT showed here and possibly related to PVN and DHA activation, must form a circuit that, when overactivated, should explain the hypergrooming behavior described here.…”

Section: Discussionsupporting

confidence: 51%

“…28 Previous work demonstrated neuroanatomical connections between the HGA and CeA, using an anterograde neuronal tracer injected in the HGA, 35,36 and neurons were labeled retrogradely following injection of tracer HRP in the PVN, showing that the CeA project directly to PVN. 37 A variety of different functions have been attributed to the amygdaloid complex, including memory, attention, interpretation of emotional significance of sensory stimuli and the production of appropriate responses. 38 Several reports suggest that the CeA participates in fear and anxiety responses 39,40,41 and neurophysiologic studies demonstrated selective electrophysiological responses of the CeA to OT.…”

Section: Introductionmentioning

confidence: 99%

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Neuroanatomical and cellular substrates of hypergrooming induced by microinjection of oxytocin in central nucleus of amygdala, an experimental model of compulsive behavior

et al. 2007

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Oxytocin (OT) is a neurosecretory nonapeptide synthesized in hypothalamic cells that project to the neurohypophysis as well as to widely distributed sites in the central nervous system. Central OT microinjections induce a variety of cognitive, sexual, reproductive, grooming and affiliative behaviors in animals. Obsessive-compulsive disorder (OCD) includes a range of cognitive and behavioral symptoms that bear some relationship with OT. Here, we study the neuroanatomical and cellular substrates of the hypergrooming induced by administration of OT in the central nucleus of amygdala (CeA). In this context, this hypergrooming is considered as a model of compulsive behavior. Our data suggest a link between the CeA and the hypothalamic grooming area (HGA). The HGA includes parts of the paraventricular nucleus and the dorsal hypothalamic area. Our data on colocalization of OT (immunohistochemistry for peptide), OT receptor (binding assay) and its retrogradely labeled cells after Fluoro-Gold injection in the CeA suggest that CeA and connections are important substrates of the circuit underlying this OT-dependent compulsive behavioral pattern.

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Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Neuroanatomical and cellular substrates of hypergrooming induced by microinjection of oxytocin in central nucleus of amygdala, an experimental model of compulsive behavior

et al. 2007

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“…It has reciprocal connections with arousal centers, such as locus coeruleus and raphe nuclei (4,59). Lesion of the PVN decreases REMS sleep and abolishes the circadian sleep-wake cycles (42).…”

Section: Discussionmentioning

confidence: 99%

Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats

Szentirmai¹,

Kapás²,

Krueger³

2007

American Journal of Physiology-Regulatory, Integrative and Comp

109

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Szentirmai É , Kapás L, Krueger JM. Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats. Am J Physiol Regul Integr Comp Physiol 292: R575-R585, 2007. First published August 17, 2006; doi:10.1152/ajpregu.00448.2006.-Ghrelin, a gutbrain peptide, is best known for its role in the stimulation of feeding and growth hormone release. In the brain, orexin, neuropeptide Y (NPY), and ghrelin are parts of a food intake regulatory circuit. Orexin and NPY are also implicated in maintaining wakefulness. Previous experiments in our laboratory revealed that intracerebroventricular injections of ghrelin induce wakefulness in rats. To further elucidate the possible role of ghrelin in the regulation of arousal, we studied the effects of microinjections of ghrelin into hypothalamic sites, which are implicated in the regulation of feeding and sleep, such as the lateral hypothalamus (LH), medial preoptic area (MPA), and paraventricular nucleus (PVN) on sleep in rats. Sleep responses, motor activity, and food intake after central administration of 0.04, 0.2, or 1 g (12, 60, or 300 pmol) ghrelin were recorded. Microinjections of ghrelin into the LH had strong wakefulness-promoting effects lasting for 2 h. Wakefulness was also stimulated by ghrelin injection into the MPA and PVN; the effects were confined to the first hour after the injection. Ghrelin's non-rapid-eye-movement sleepsuppressive effect was accompanied by attenuation in the electroencephalographic (EEG) slow-wave activity and changes in the EEG power spectrum. Food consumption was significantly stimulated after microinjections of ghrelin into each hypothalamic site. Together, these results are consistent with the hypothesis that forebrain ghrelinergic mechanisms play a role in the regulation of vigilance, possibly through activating the components of the food intake-and arousalpromoting network formed by orexin and NPY. lateral hypothalamus; medial preoptic area; paraventricular nucleus; electroencephalogram; slow-wave activity; sleep GHRELIN IS A 28-AMINO ACID peptide produced by endocrine cells in the gastrointestinal system and by neurons in the central nervous system (21). Circulating ghrelin is derived mainly from the stomach (1). Plasma ghrelin levels inversely correlate with feeding; fasting increases, while food intake reduces, plasma ghrelin concentrations (7, 61). In the brain, ghrelin is produced by arcuate nucleus (ARC) neurons and by a distinct hypothalamic neuronal population in the internuclear region (6). Ghrelin's actions are mediated by the growth hormone secretagogue receptor (GHS-R) (21). GHS-R mRNA is widely distributed in the gastrointestinal tract, sensory vagus fibers, and the brain. Those hypothalamic nuclei that are implicated in the regulation of feeding and/or sleep-wake activity, such as the lateral hypothalamus (LH), paraventricular nucleus (PVN), ARC, dorsomedial hypothalamic nucleus, anteroventral preoptic nucleus, anterior hypothalamic area, suprachiasmatic nucleus, anterolateral hypothalamic nucleus, and the...

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“…Consequently, it regulates the activation of the HPA-axis via projections to the hypothalamus, which might underlie the increase of depressive behaviors and mood alterations. Some reports have indicated that neurons in CeA have direct projections to many areas in brain, including PVN in the hypothalamus [34][35][36][37] . Transmitter release from the amygdala onto PVN has been identified by Gray [35] .…”

mentioning

confidence: 99%

Increased expression level of corticotropin-releasing hormone in the amygdala and in the hypothalamus in rats exposed to chronic unpredictable mild stress

et al. 2010

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Objective Corticotropin-releasing hormone (CRH) plays an important role in neuroendocrine, autonomic and behavioral responses to stressors. In the present study, the effect of chronic unpredictable mild stress (CUMS) on CRH neurons was investigated in rat brain. Methods The rats were exposed to one of the stressors each day for 21 d. Immunostaining was performed to detect the CRH-positive neurons in the paraventricular nucleus (PVN) of the hypothalamus and in amygdala.Results After the stress protocol, the animals showed a reduction in body weight gain as well as reduced sucrose preference and locomotor activity. Interestingly, the CRH neurons in both PVN and central nucleus of the amygdala (CeA) were stimulated by CUMS. The densities of CRH-containing neurons in both PVN and CeA were significantly higher than those in control group. Conclusion The CRH systems in PVN and CeA may both contribute to depression-like behaviors during CUMS.

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Localization of neurones projecting to the hypothalamic paraventricular nucleus area of the rat: A horseradish peroxidase study

Cited by 207 publications

References 46 publications

Neuroanatomical and cellular substrates of hypergrooming induced by microinjection of oxytocin in central nucleus of amygdala, an experimental model of compulsive behavior

Neuroanatomical and cellular substrates of hypergrooming induced by microinjection of oxytocin in central nucleus of amygdala, an experimental model of compulsive behavior

Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats

Increased expression level of corticotropin-releasing hormone in the amygdala and in the hypothalamus in rats exposed to chronic unpredictable mild stress

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