Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization

Close kinship of human 20α‐hydroxysteroid dehydrogenase gene with three aldo‐keto reductase genes

“…Therefore, the four AKR genes were located close together on the same region of the chromosome. These results were consistent with the previous report from uorescent in situ hybridization (FISH), that the 20a-HSD, BABP and DD4 loci are sited on chromosome 10p14-p15 (Khanna et al 1995a). …”

Identification of a Functional Polymorphism of the Human Type 5 17β-Hydroxysteroid Dehydrogenase Gene Associated with Polycystic Ovary Syndrome

“…On the other hand, the 17␤-HSD5 gene (HSD17B5) is widely expressed and is found in the ovary and adrenal gland (8 -13). Human HSD17B5 is composed of nine exons spanning 16 kb and is located on chromosome 10p14,15 (11,14). We recently reported that a binding site for the ubiquitous transcription factors Sp1/Sp3 in the HSD17B5 proximal promoter is necessary for gene activity (15).…”

Molecular Endocrinology of Hydroxysteroid Dehydrogenases*

“…The rat 3␣-HSD gene is more than 47 kb long, whereas the type I and type II human 3␣-HSD genes are 20 and 16 kb in length, respectively (121). The human type I 3␣-HSD is located on chromosome 10 at p14 (133) To understand what controls high constitutive expression and regulated expression in rat liver, detailed functional studies have been performed on the rat 3␣-HSD gene (130). The bulk of the 2.7-kb transcript encodes for a long 3Ј-UTR which may be an important determinant in mRNA stability (134,135).…”