Localization of impaired cortical neurons by EEG power fluctuation analysis

Musha, Toshimitsu; Mochiduki, Yuusuke; Kurachi, Takayoshi; Asada, Takashi

doi:10.1016/j.ics.2004.04.051

Cited by 4 publications

(3 citation statements)

References 4 publications

(4 reference statements)

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“…NAT provides rich information about neuronal activities by quantitative EEG analysis (Musha et al, 2002 , 2004 , 2013 ; Shibata et al, 2014 ), which comprises 210 submarkers referring to the 10 frequency components ranging from 4 to 20 Hz. Each submarker has its own role in the characterization of neuronal activities, which are represented with the 210-dimensional NAT spaces.…”

Section: Methodsmentioning

confidence: 99%

Boundary EEG Asymmetry Is Associated to Linguistic Competence in Vascular Cognitive Impairments

Shibata

Musha²,

Kosugi³

et al. 2018

Front. Hum. Neurosci.

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Background and Purpose: We recently noted a gradual change in the boundary electroencephalography (EEG) oscillation of 7.8 Hz between theta (θ) and alpha (α) bands in response to increased atherosclerosis levels in the elderly. The aim of this study was to investigate the role of boundary EEG oscillations of θ-α bands on cognitive functions in vascular cognitive impairments (VCI) patients.Materials and Methods: We examined 55 patients with VCI in carotid stenosis, and underwent EEG in a resting state with closed eyes for 5 min. The asymmetry index (AI) along homologous channel pairs (e.g., F7-8) was assessed using neuronal activity topography (NAT). AI referring to 10 frequency components ranging from 4 to 20 Hz and neuropsychological assessments including linguistic competence were analyzed.Results: The main findings was that the language score had a positive association with AI in 7.8 Hz at F7-8 and a negative association with AI in 6.3 Hz at C3-4 and 14.1 Hz at F3-4.Conclusion: EEG asymmetry in a boundary range might have a special role in linguistic competence, suggesting the application of neural oscillation on the cognitive function evaluation and neurorehabilition induced by a frequency-specific transcranial alternating current stimulation.

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Section: Methodsmentioning

confidence: 99%

Boundary EEG Asymmetry Is Associated to Linguistic Competence in Vascular Cognitive Impairments

Shibata

Musha²,

Kosugi³

et al. 2018

Front. Hum. Neurosci.

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“…Each submarker has its own role in the characterization of cerebral neuronal activity, which is represented by the 210-dimensional NAT spaces. The NAT system has been used to detect Alzheimer's disease (AD) and to discriminate AD from other forms of dementia, VCI, dementia with lewy bodies, and is currently undergoing testing for its practical use in the clinical setting (Musha et al, 2002 , 2004 , 2013 ). Recently, we reported on VCI templates, consisting of patients with VCI associated with moderate carotid stenosis (>60%) and normal controls (NLc) (Shibata et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Altered Neuronal Activity Topography Markers in the Elderly with Increased Atherosclerosis

Shibata

Musha²,

Kosugi³

et al. 2017

Front. Aging Neurosci.

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Background: Previously, we reported on vascular cognitive impairment (VCI) templates, consisting of patients with VCI associated with carotid stenosis (>60%) using a quantitative electroencephalographic (EEG) technique called neuronal activity topography (NAT). Here using the VCI templates, we investigated the hypothesis that internal carotid artery–intima-media thickness (ICA–IMT) is associated with EEG spectrum intensity (sNAT) and spectrum steepness (vNAT).Methods: A total of 221 community-dwelling elderly subjects were recruited. Four groups were classified according to quartiles of ICA–IMT as assessed by ultrasonography: control group A, normal (≤0.9 mm); group B, mild atherosclerosis (1−1.1 mm); group C, moderate atherosclerosis (1.2−1.8 mm); and group D, severe atherosclerosis (≥1.9 mm). EEG markers of power ratio index (PRI), and the binary likelihood of being in the VCI group vs. the that of being in control group A (sLx:VCI−A, vLx:VCI−A) were assessed, respectively. Differences in mean total scores for PRI, sLx:VCI−A, vLx:VCI−A, between control group A and the other groups were compared using Dunnett's test, respectively.Results: The mean total scores of the PRI were 3.25, 3.00, 2.77, and 2.26 for groups A, B, C, and D, respectively. There was a significant decrease in the PRI in group D compared with group A (P = 0.0066). The mean total scores of the sLx:VCI−A were −0.14, −0.11, −0.1, and −0.03 for groups A, B, C, and D, respectively. The sLx:VCI−A in group D was significantly higher compared to that in group A (P < 0.0001). The mean total scores of the vLx:VCI−A were −0.04,−0.01, 0.01, and 0.06 for group A, B, C, and D, respectively. The vLx:VCI−A in group D and group C was significantly higher compared to that in group A, respectively (P < 0.0001, P = 0.02).Conclusion: Community-dwelling elderly subjects in the increased carotid atherosclerosis of ICA–IMT (≥1.9 mm) were at greatest risk of an EEG change as assessed by NAT.

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“…The EEG is rich in information on cortical, neuronal activity in the brain and an appropriate signal processing will give valuable information on the brain activity which could not be obtained by other imaging tools (Musha et al 2004). A number of studies have confirmed that quantitative EEG (qEEG) analyses are far superior to conventional EEG in the detection of subtle alterations of EEG background activity (John 1989;Fitz-Gerald and Patrick 1991); they reflect the time course of pharmacologic effects of a drug and provide an independent measure of bioavailability in the CNS (Knott 2000).…”

Section: Introductionmentioning

confidence: 99%

Effect of high dose cytosine arabinoside on quantitative EEG in patients with acute myeloid leukemia

Maschio¹,

Marchesi²,

Dispenza

et al. 2016

Cogn Neurodyn

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Background EEG activity is considered an index of functional state of brain. Chemotherapy (CT), used for non-central nervous system (CNS) cancer, can cross the blood brain barrier and contribute to changes in the functional state of brain that can alter background EEG activity. Quantitative EEG (qEEG) is superior to conventional EEG in the detection of subtle alterations of EEG background activity and for this reason, the use of qEEG might assist the clinician in evaluating the possible effect of CT on the CNS. The nucleoside analog cytosine arabinoside (Ara-C) is one of the milestone chemotherapeutic agents used for treatment of acute myeloid leukemia (AML). Our observational study evaluates the possible effect of Ara-C on the qEEG of patients with AML, without CNS involvement. We conducted an observational study on newly diagnosed AML patients without CNS involvement, undergoing treatment with Ara-C to analyze the possible effect of Ara-C high doses on EEG background activity using qEEG analyses. A total of nine AML patients, 5 with Ara-C i.v. high dose (C3 g/m 2 die), 4 with standard dose (100 mg/m 2 die) underwent qEEG (at rest, during hyperpnoea, mental arithmetic task and blocking reaction). We compared the EEG background activity of the two groups at baseline and after 6 months. Statistical analysis showed no significant differences between the two groups in mean relative power for all frequency bands, at rest and during hyperpnoea, mental arithmetic task and blocking reaction. Our data indicate that high dose Ara-C i.v. did not induce significant changes on EEG background activity in our patients. Future research in this area could include prospective studies that would combine qEEG and neuropsychological testing to assess the impact of CT on brain functions.

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Localization of impaired cortical neurons by EEG power fluctuation analysis

Cited by 4 publications

References 4 publications

Boundary EEG Asymmetry Is Associated to Linguistic Competence in Vascular Cognitive Impairments

Boundary EEG Asymmetry Is Associated to Linguistic Competence in Vascular Cognitive Impairments

Altered Neuronal Activity Topography Markers in the Elderly with Increased Atherosclerosis

Effect of high dose cytosine arabinoside on quantitative EEG in patients with acute myeloid leukemia

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