Localization of <i>Helicobacter pylori</i> gastritis and the relation of existing histopathological features with reflux esophagitis

Yalakı, Serkan; Pülat, Hüseyin; Ilhan, Aysu

doi:10.1080/00365521.2019.1701071

Cited by 11 publications

(14 citation statements)

References 32 publications

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“…A study by Yalaki et al, aimed at comparing and evaluating the relationship between GERD and H. pylori in adult patients with gastric localization of H. pylori infection and its historical features, the incidence of H. pylori has been shown to be signi cantly lower in patients with GERD than in the control group. This result is not consistent with the results of our study (5).…”

Section: Discussioncontrasting

confidence: 99%

“…H. pylori, as a common infection, plays an important role in the pathogenesis of various benign and malignant gastroduodenal diseases including gastric ulcer, gastric mucosal lymphoma and gastric cancer (4), however, there is still no agreement on its role in GERD. According to some reports, an inverse relationship between H. pylori and GERD has been observed (5,(16)(17)(18)(19), but some other studies have not shown this relationship (12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

“…Helicobacter pylori (H. pylori), as a gram-negative bacterium, plays an important role in the pathogenesis of different GI diseases including gastric ulcer, gastric mucosal lymphoma and gastric cancer (4). However, the relationship between H. pylori and GERD is a complex and confusing subject that needs further investigation (5,6). Some studies have reported a higher prevalence of H. pylori in patients with GERD, while some have observed an inverse relationship.…”

Section: Introductionmentioning

confidence: 99%

“…To date, the true relationship of H. pylori to GERD is still unclear (4), and recent studies have shown that more research is needed to clarify this association, with a more focus on confounding factors in GERD and H pylori (5)(6)(7), so we designed this study.…”

Section: Introductionmentioning

confidence: 99%

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The Association Between Helicobacter Pylori Infection and Erosive Gastroesophageal Reflux Disease; a Cross-Sectional Study

Niknam

Lankarani

Moghadami

et al. 2021

Preprint

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Background The association between H. pylori (Helicobacter pylori) infection and gastroesophageal reflux disease (GERD) is a complex and confusing subject, so we designed this study. Method In a cross-sectional study, all patients referred for endoscopy due to dyspepsia were enrolled. The diagnosis of erosive GERD was made by endoscopy. Patients with normal esophagus were selected as comparison group. Random gastric biopsies were taken from all participants to diagnose H. pylori infection. Result In total, 1916 patients were included in this study, of whom 45.6% had GERD. The mean age (SD) was 42.95 (16.32). Overall, 1442 (75.3%) patients were positive for H. pylori infection. The frequency of H. pylori infection in mild GERD patients was higher than the severe GERD, but this difference was not significant (P=0.214). Except for sociodemographic status (P < 0.001), other variables including gender, age, ethnicity, body mass index (BMI), smoking, and presence of hiatus hernia in patients had no significant association with the frequency of H. pylori infection. According to Robust Poisson regression models analysis, the association of H. pylori (PR 1.026;95%CI 0.990-1.064; P=0.158) and sociodemographic status were not significantly different between the two groups. But smoking, increased BMI, older age, presence of hiatus hernia, and peptic ulcer diseases were significantly associated with GERD compared with the non-GERD group. Conclusion In our results, there was no association between H. pylori infection and erosive GERD. Further studies are recommended, especially considering the effects of pathophysiological and other confounding factors on H. pylori and GERD.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Association Between Helicobacter Pylori Infection and Erosive Gastroesophageal Reflux Disease; a Cross-Sectional Study

Niknam

Lankarani

Moghadami

et al. 2021

Preprint

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“…A significantly lower amount of H pylori infection was found in the corpus of subjects presenting with erosive reflux disease compared to controls whereas no differences were detected in antrum predominant gastritis and atrophic lesions. The authors concluded that hypoacidity driven by corpus predominant gastritis was the reason for these observations 1 . Screening by esophagogastroduodenoscopy (EGD) before bariatric surgery is frequently applied to detect contraindications which may change the planned surgical procedure.…”

Section: Esophageal Diseasesmentioning

confidence: 99%

Review ‐ Helicobacter pylori and non‐malignant upper gastro‐intestinal diseases

Schulz

Kupčinskas

2020

Helicobacter

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This review takes into account recent publications focusing on the relationship between Helicobacter pylori infection and non‐malignant diseases of the upper gastro‐intestinal tract. The authors have summarized current knowledge on associations between the H pylori infection and non‐malignant upper GI conditions including gastroesophageal reflux disease (GERD), Barrett's esophagus, eosinophilic esophagitis (EOE), peptic ulcer disease (PUD), H pylori gastritis, celiac disease and functional dyspepsia. In the field of GERD, current data focusing on different locations of H pylori infection detect significant differences between antrum‐ and corpus predominant gastritis explainable by different changes in acid secretion in different gastric niches. High volume studies from Sweden and Brazil underline the safety of H pylori eradication concerning the risk of Barret's esophagus or adenocarcinoma. The relationship betweenH pylori infection and EOE remains uncertain, but current data supports the concept of expected positive and protective effects of H pylori exposure reducing the risk of EOE. Analyzing biomarkers might be helpful to identify subjects under risk for the development of precancerous lesions after H pylori infection, where microRNAs, IL‐9 and IL‐4, and also Tc17/9 and Th17/9 and microbiota profiles showed promising results to identify subgroups under risk.

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Aktualisierte S2k-Leitlinie Helicobacter pylori und gastroduodenale Ulkuskrankheit der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – Juli 2022 – AWMF-Registernummer: 021–001

2023

Z Gastroenterol

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Localization of Helicobacter pylori gastritis and the relation of existing histopathological features with reflux esophagitis

Cited by 11 publications

References 32 publications

The Association Between Helicobacter Pylori Infection and Erosive Gastroesophageal Reflux Disease; a Cross-Sectional Study

The Association Between Helicobacter Pylori Infection and Erosive Gastroesophageal Reflux Disease; a Cross-Sectional Study

Review ‐ Helicobacter pylori and non‐malignant upper gastro‐intestinal diseases

Aktualisierte S2k-Leitlinie Helicobacter pylori und gastroduodenale Ulkuskrankheit der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – Juli 2022 – AWMF-Registernummer: 021–001

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