Localization of fibroblast growth factor-9 mRNA in the rat brain

Tagashira, Shuzou; Ozaki, Kei-ichi; Ohta, Mitsuhiro; Itoh, Nobuyuki

doi:10.1016/0169-328x(95)00009-h

Cited by 47 publications

(29 citation statements)

References 21 publications

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“…Because extension of cellular processes is essential for the myelination of axons by OLs, FGF-9/FGFR2 signaling may have relevance for myelination in vivo. Consistent with this, FGF-9 and FGFR2 are expressed in the white matter, including the active phase of myelination (Tagashira et al, 1995;Miyake et al, 1996;Nakamura et al, 1999;Bansal et al, 2003b). It is interesting to note that, although FGF-2 induces process elongation, it also downregulates the synthesis of myelin proteins, accompanied by loss of membranes.…”

Section: Fgf Regulation Of Ol Proliferation and Differentiationmentioning

confidence: 50%

Distinct Fibroblast Growth Factor (FGF)/FGF Receptor Signaling Pairs Initiate Diverse Cellular Responses in the Oligodendrocyte Lineage

Fortin¹,

Rom²,

Sun³

et al. 2005

J. Neurosci.

144

166

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Fibroblast growth factors (FGFs) have been implicated in numerous cellular processes, including proliferation, migration, differentiation, and survival. Whereas FGF-2, the prototypic ligand in a family of 22 members, activates all four tyrosine kinase FGF receptors (FGFR1-FGFR4), other members demonstrate a higher degree of selectivity. Oligodendrocytes (OLs), the myelin-producing cells of the CNS, are highly influenced by FGF-2 at all stages of their development. However, how other FGFs and their cognate receptors orchestrate the development of OLs is essentially undefined. Using a combination of specific FGF ligands and receptor blocking antibodies, we now show that FGF-8 and FGF-17 target OL progenitors, inhibiting their terminal differentiation via the activation of FGFR3, whereas FGF-9 specifically targets differentiated OLs, triggering increases in process growth via FGFR2 signaling; FGF-18 targets both OL progenitors and OLs via activation of both FGFR2 and FGFR3. These events are highly correlated with changes in FGF receptor expression from FGFR3 to FGFR2 as OL progenitors differentiate into mature OLs. In addition, we demonstrate that, although activation of FGFR1 by FGF-2 leads to proliferation of OL progenitors, it produces deleterious effects on differentiated OLs (i.e., aberrant reentry into cell cycle and downregulation of myelin proteins with a loss of myelin membrane). These data suggest that ligand availability, coupled with changes in FGF receptor expression, yield a changing repertoire of ligand-receptor signaling complexes that contribute critically to the regulation of both normal OL development and potential OL/myelin pathogenesis.

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Section: Fgf Regulation Of Ol Proliferation and Differentiationmentioning

confidence: 50%

Distinct Fibroblast Growth Factor (FGF)/FGF Receptor Signaling Pairs Initiate Diverse Cellular Responses in the Oligodendrocyte Lineage

Fortin¹,

Rom²,

Sun³

et al. 2005

J. Neurosci.

144

166

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“…FGF-5 is expressed in distinct regions of the CNS, including the cerebral cortex, hippocampus, thalamus, and cerebellar granule layer (Hattori et al, 1997;Haub et al, 1990;Gomez-Pinilla and Cotman, 1993). FGF-9 displays a wider distribution and is found in the olfactory bulb, caudate/putamen, cerebral cortex, hippocampus, thalamus, midbrain, brain stem, and cerebellum (Tagashira et al, 1995;Todo et al, 1998). FGFs differ not only in their distributional patterns, but also with respect to their cellular sites of synthesis.…”

Section: Introductionmentioning

confidence: 98%

Fibroblast growth factors-5 and -9 distinctly regulate expression and function of the gap junction protein connexin43 in cultured astroglial cells from different brain regions

Reuss

Hertel

Werner

et al. 2000

Glia

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“…They target a wide array of cell types, affecting many biological activities that include either inhibition or stimulation of differentiation, proliferation, migration and survival. Numerous members of the FGF family are present in the CNS during development (e.g., [Ford-Perriss et al, 2001 and references therein; Giordano et al, 1992;Tagashira et al, 1995]. In the adult brain FGF-1 and FGF-9 are expressed preferentially in neurons, whereas FGF-2 is expressed in both neurons and glial cells.…”

Section: Fibroblast Growth Factors (Fgfs) and Their Receptorsmentioning

confidence: 99%

Fibroblast Growth Factors and Their Receptors in Oligodendrocyte Development: Implications for Demyelination and Remyelination

et al. 2002

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Fibroblast growth factors are a family of broad-spectrum growth factors influencing a plethora of cellular activities. The interaction of at least 23 ligands, 4 receptors and multiple coreceptors provides a dramatic complexity to a signaling system capable of effecting a multitude of responses. This review focuses on the fibroblast growth factors signaling in oligodendrocyte development, function and discusses implications for demyelination/remyelination.

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Localization of fibroblast growth factor-9 mRNA in the rat brain

Cited by 47 publications

References 21 publications

Distinct Fibroblast Growth Factor (FGF)/FGF Receptor Signaling Pairs Initiate Diverse Cellular Responses in the Oligodendrocyte Lineage

Distinct Fibroblast Growth Factor (FGF)/FGF Receptor Signaling Pairs Initiate Diverse Cellular Responses in the Oligodendrocyte Lineage

Fibroblast growth factors-5 and -9 distinctly regulate expression and function of the gap junction protein connexin43 in cultured astroglial cells from different brain regions

Fibroblast Growth Factors and Their Receptors in Oligodendrocyte Development: Implications for Demyelination and Remyelination

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