Localization of factor VII (proconvertin) in a microsomal subfraction

Gaarder, Anne; Prydz, Hans

doi:10.1016/0304-4165(69)90122-6

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1971

1975

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Cited by 7 publications

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“…Phenylindanedione (and other similar anticoagulants) therefore probably acted after the polypeptide synthesis had taken place. Kinetic studies on the factor VII content of a smooth microsomal fraction from rat liver (3,4) indicated that warfarin acted shortly after cycloheximide in the biosynthetic pathway (21 ). The final stages of factor VII transport out of the liver cells were not inhibited by warfarin (17,21), leaving the coupling of carbohydrates to the polypeptide chain as the most likely process to be inhibited.…”

Section: Discussionmentioning

confidence: 99%

Factor X

Prydz¹,

Gladhaug²

1971

Thromb Haemost

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SummaryA monospecific antiserum against factor X was prepared in rabbits. The antiserum precipitated factor X in human plasma and serum and monkey serum. The antiserum was used to :1. demonstrate the presence of factor X precursor in blood from patients under anticoagulant therapy,2. produce an artificial factor X deficiency substrate useful for testing factor X,3. study the species specificity of factor X from various common laboratory mammals.

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