Localization of Estrogen Receptor in the Central Lymphoid Organs of Chickens during the Late Stage of Embryogenesis

Katayama, Masafumi; Fukuda, T.; Narabara, Kiyoaki; Abe, Asaki; Kondo, Yasuhiro

doi:10.1271/bbb.120182

Cited by 6 publications

(10 citation statements)

References 30 publications

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“…In the embryonic thymus, T-cell receptor (TcR)αβ-positive T cells appear at day 14 and start entry into the medulla of the thymus at day 17 of development (Bucy et al 1990). These results are consistent with our previous publication, indicating the high expression of ER in thymus tissue (Katayama et al 2012). The high expression level of ER at the 16th day of the developmental stage detected in this study suggests the association of ER expression with T-cell differentiation.…”

Section: Discussionsupporting

confidence: 94%

“…We could not detect any gender-or agerelated differences from all the microscopy results. These results of staining, including intra-cellar localization, are consistent with that of our previous report (Katayama et al 2012). 3C).…”

Section: Histological Detection Of Er-expressing Cells In the Thymussupporting

confidence: 93%

“…As a consistent result to support the effect of estrogen on the chick immune function, estrogen treatment on the third day of embryogenesis impaired antibody formation posthatching (Verheul et al 1986). Furthermore, the detailed distribution of ER in the chick thymus has already been reported (Katayama et al 2012). In the chick thymus, the expression of ERα was detected, but there was no expression in the case of ERβ .…”

Section: Introductionmentioning

confidence: 80%

“…In the chick thymus, the expression of ERα was detected, but there was no expression in the case of ERβ ). Furthermore, the detailed distribution of ER in the chick thymus has already been reported (Katayama et al 2012). We hypothesized that in the embryonic stage of the chick, there is a possibility that the expression level of ERα messenger RNA (mRNA) might change dramatically in the thymus tissue.…”

Section: Introductionmentioning

confidence: 99%

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Changes in estrogen receptor expression in the chick thymus during late embryonic development

Katayama

Fukuda

Hatabu

et al. 2013

Animal Science Journal

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In chickens, although estrogen receptors (ER) are reported to be associated with the immunological processes, detailed information about the differences in ER expression in the tissues related to the development of lymphocytes is not fully known, especially during the developmental stage. To learn more about this immunological relationship, we used semi-quantitative polymerase chain reaction method to detect the ER expression levels in the thymus tissues of chicks during the developmental stage. Furthermore, ER-expressing cells were detected by immunohistochemistry. The results of this study show that the expression level of ER increased on embryonic day 16 and decreased on day 20. Furthermore, ER expression was significantly higher in male than in female chickens at day 16. The increased expression on day 16 and decreased level on day 20 were also reproduced in the incidence of immunoreactive cells, although there was a 1-day delay in the elevated incidence of the cells. This study revealed the changes in ER expression and the incidence of ER-positive cells in the thymus of chickens during the developmental stage.

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Section: Discussionsupporting

confidence: 94%

Section: Histological Detection Of Er-expressing Cells In the Thymussupporting

confidence: 93%

Section: Introductionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Changes in estrogen receptor expression in the chick thymus during late embryonic development

Katayama

Fukuda

Hatabu

et al. 2013

Animal Science Journal

Self Cite

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“…Receptors for estrogen are expressed in lymphocytes from the thymus, bursa, and spleen of chickens [49]. Receptors for estrogen are expressed in lymphocytes from the thymus, bursa, and spleen of chickens [49].…”

Section: Estrogenmentioning

confidence: 99%

Factors Modulating the Avian Immune System

Koutsos

Klasing

2014

Avian Immunology

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Endocrine-Disrupting Chemical Exposure and the American Alligator: A Review of the Potential Role of Environmental Estrogens on the Immune System of a Top Trophic Carnivore

Finger

Gogal

2013

Arch Environ Contam Toxicol

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Endocrine-disrupting chemicals (EDCs) alter cellular and organ system homeostasis by interfering with the body's normal physiologic processes. Numerous studies have identified environmental estrogens as modulators of EDC-related processes in crocodilians, notably in sex determination. Other broader studies have shown that environmental estrogens dysregulate normal immune function in mammals, birds, turtles, lizards, fish, and invertebrates; however, the effects of such estrogenic exposures on alligator immune function have not been elucidated. Alligators occupy a top trophic status, which may give them untapped utility as indicators of environmental quality. Environmental estrogens are also prevalent in the waters they occupy. Understanding the effects of these EDCs on alligator immunity is critical for managing and assessing changes in their health and is thus the focus of this review.

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Localization of Estrogen Receptor in the Central Lymphoid Organs of Chickens during the Late Stage of Embryogenesis

Cited by 6 publications

References 30 publications

Changes in estrogen receptor expression in the chick thymus during late embryonic development

Changes in estrogen receptor expression in the chick thymus during late embryonic development

Factors Modulating the Avian Immune System

Endocrine-Disrupting Chemical Exposure and the American Alligator: A Review of the Potential Role of Environmental Estrogens on the Immune System of a Top Trophic Carnivore

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