Localization of dopamine receptor subtypes occupied by intra-accumbens antagonists that reverse cocaine-induced locomotion

Neisewander, Janet L.; O’Dell, Laura E.; Redmond, John C.

doi:10.1016/0006-8993(94)01317-b

Cited by 38 publications

(43 citation statements)

References 40 publications

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“…However, in the present study and many other intracranial infusion studies, SCH-23390 amounts used intracranially are similar to those used systemically, with less than a 10-fold difference between them. Previous research has sought to address this concern by examining the percentage of D1 receptors occupied following either systemic or intra-accumbens SCH-23390 administration (Neisewander et al, 1995. These studies showed that similar percentages of receptors in the nucleus accumbens were occupied following approximately 9 mg SCH-23390 administered systemically or 6 mg infused directly into the nucleus accumbens (3 mg/side; Neisewander et al, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…Previous research has sought to address this concern by examining the percentage of D1 receptors occupied following either systemic or intra-accumbens SCH-23390 administration (Neisewander et al, 1995. These studies showed that similar percentages of receptors in the nucleus accumbens were occupied following approximately 9 mg SCH-23390 administered systemically or 6 mg infused directly into the nucleus accumbens (3 mg/side; Neisewander et al, 1995). While it is not clear why direct intracranial administration does not more potently occupy D1 receptors than systemic administration, this finding is consistent with the common practice of utilizing similar amounts of SCH-23390 systemically and intracranially.…”

Section: Discussionmentioning

confidence: 99%

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Effects of SCH-23390 Infused into the Amygdala or Adjacent Cortex and Basal Ganglia on Cocaine Seeking and Self-Administration in Rats

Alleweireldt

Hobbs

Taylor

et al. 2005

Neuropsychopharmacol

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Amygdala D1 receptors have been implicated in the motivating effects of cocaine-conditioned cues and cocaine itself, but the specific nucleus involved is unclear. Thus, we infused the D1 antagonist, SCH-23390, into the rostral basolateral amygdala (rBLA), caudal basolateral amygdala (cBLA), or central amygdala (CEA), and tested its effects on self-administration of cocaine, as well as reinstatement of extinguished cocaine-seeking behavior by cocaine-conditioned cues or cocaine itself. Two anatomical controls, the posterior regions of basal ganglia (BG) and somatosensory/insular cortices (CTX), were also examined. Cocaine self-administration was increased and cue and cocaine reinstatement were decreased by SCH-23390 infusion into every region when examined across the hour test session, with the exception that cBLA infusion did not alter cocaine reinstatement. In the first 20 min of the session, when SCH-23390 was more localized in the target sites, self-administration was increased by infusion into the CEA, cBLA, BG, and CTX, with lesser increases in the rBLA. Cocaine reinstatement was attenuated during the first 20 min only by infusion into the CEA, rBLA, and CTX. Cue reinstatement was not reliably observed in the first 20 min, but there was a trend for attenuation by infusion into the cBLA, and surprisingly, significant attenuations in the BG and CTX. The findings suggest that D1 receptors in subregions of the amygdala play differential roles in the reinforcing/motivational effects of cocaine, while the cue reinstatement effects are less clear. Further research is needed to examine the novel findings that neighboring regions of the BG and CTX may play a role in motivation for cocaine.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of SCH-23390 Infused into the Amygdala or Adjacent Cortex and Basal Ganglia on Cocaine Seeking and Self-Administration in Rats

Alleweireldt

Hobbs

Taylor

et al. 2005

Neuropsychopharmacol

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“…Furthermore, stereotypies are more prevalent following intracaudate cocaine administration, whereas locomotion is more prevalent following intraaccumbens cocaine administration . D2-selective antagonists reverse cocaineinduced stereotypies when infused into the CPu (Arnt, 1985), and reverse cocaine-induced locomotion when infused into the NAc (Baker et al, 1996;Neisewander et al, 1995). D1-selective antagonists also reverse cocaine-induced stereotypies when administered into the CPu (Arnt, 1985).…”

Section: Introductionmentioning

confidence: 88%

Effects of intraaccumbens administration of SCH-23390 on cocaine-induced locomotion and conditioned place preference

Baker

Fuchs

Specio

et al. 1998

Synapse

Self Cite

102

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The effects of systemic (0-1.0 mg/kg) or intraaccumbens (0-1.0 microg/side) administration of SCH-23390 on cocaine-induced (0 or 4.2 mg/kg, i.v.) locomotion, sniffing, and conditioned place preference (CPP) were investigated in rats. After behavioral testing was completed, animals were injected with their respective dose of SCH-23390 into the nucleus accumbens (NAc), followed by a systemic injection of the irreversible antagonist N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). Receptors occupied by intraaccumbens SCH-23390, and therefore protected from EEDQ-induced inactivation, were then quantified from autoradiograms of sections labeled with 3H-SCH-23390. Systemic administration of 0.5 and 1.0 mg/kg SCH-23390 reversed cocaine-induced locomotion, sniffing, and CPP, suggesting that stimulation of D1-like receptors is necessary for these behavioral changes. Intraaccumbens administration of 1.0 microg/side SCH-23390 reversed cocaine-CPP, and this dose occupied D1-like receptors primarily in the rostral pole of the NAc. Intraaccumbens administration of 0.5 microg/side SCH-23390 reversed cocaine-induced locomotion. However, this dose occupied a similar number of D1-like receptors in the NAc as a lower and behaviorally ineffective dose of 0.1 microg/side, but occupied more receptors in the caudate-putamen relative to both the 0.1 and 1.0 microg/side doses. These findings suggest that stimulation of D1-like receptors in the NAc is necessary for cocaine-CPP, but not for cocaine-induced locomotion.

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“…All drugs were dissolved in PBS, except SCH 23390, which was dissolved in sterile saline. Doses of all four drugs were chosen based on previous work indicating a lack of effect of the high dose of the drug on locomotor activity and/or reinstatement lever pressing (Neisewander et al, 1995;Cornish and Kalivas, 2000;McFarland and Kalivas, 2001;Anderson et al, 2003Anderson et al, , 2006.…”

Section: Methodsmentioning

confidence: 99%

Glutamate Release in the Nucleus Accumbens Core Is Necessary for Heroin Seeking

LaLumiere¹,

Kalivas²

2008

J. Neurosci.

325

286

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Long-term changes in glutamate transmission in the nucleus accumbens core (NAcore) contribute to the reinstatement of drug seeking after extinction of cocaine self-administration. Whether similar adaptations in glutamate transmission occur during heroin and cueinduced reinstatement of heroin seeking is unknown. After 2 weeks of heroin self-administration and 2 weeks of subsequent extinction training, heroin seeking was induced by a noncontingent injection of heroin or by presentation of light/tone cues previously paired with heroin infusions. Microdialysis was conducted in the NAcore during reinstatement of heroin seeking in animals extinguished from heroin self-administration or in subjects receiving parallel (yoked) noncontingent saline or heroin. Reinstatement by either heroin or cue increased extracellular glutamate in the NAcore in the self-administration group, but no increase was elicited during heroin-induced reinstatement in the yoked control groups. The increase in glutamate during heroin-induced drug seeking was abolished by inhibiting synaptic transmission in the NAcore with tetrodotoxin or by inhibiting glutamatergic afferents to the NAcore from the prelimbic cortex. Supporting critical involvement of glutamate release, heroin seeking induced by cue or heroin was blocked by inhibiting AMPA/kainate glutamate receptors in the NAcore. Interestingly, although a heroin-priming injection increased dopamine equally in animals trained to self-administer heroin and in yoked-saline subjects, inhibition of dopamine receptors in the NAcore also blocked heroin-and cueinduced drug seeking. Together, these findings show that recruitment of the glutamatergic projection from the prelimbic cortex to NAcore is necessary to initiate the reinstatement of heroin seeking.

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Localization of dopamine receptor subtypes occupied by intra-accumbens antagonists that reverse cocaine-induced locomotion

Cited by 38 publications

References 40 publications

Effects of SCH-23390 Infused into the Amygdala or Adjacent Cortex and Basal Ganglia on Cocaine Seeking and Self-Administration in Rats

Effects of SCH-23390 Infused into the Amygdala or Adjacent Cortex and Basal Ganglia on Cocaine Seeking and Self-Administration in Rats

Effects of intraaccumbens administration of SCH-23390 on cocaine-induced locomotion and conditioned place preference

Glutamate Release in the Nucleus Accumbens Core Is Necessary for Heroin Seeking

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