Localization of cellular changes within multimodal sensory regions in aged monkey brain: Possible implications for age-related cognitive loss☆

Brizzee, Kenneth R.; Ordy, J. M.; Bartus, Raymond T.

doi:10.1016/0197-4580(80)90023-8

Cited by 93 publications

(33 citation statements)

References 25 publications

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“…Early studies by Brizzee and colleagues (Brizzee et al 1980) utilized density measures to evaluate the brain of aged monkeys and reported a reduction of neuron density in the CA1 field of the hippocampus and in area 46 of the prefrontal cortex, two areas critical to cognitive function. Despite the limited sampling, this study appeared to corroborate studies of the aging human brain such as Brody (1955) and Ball (1977) that reported similar findings for human brains using similar sampling methods.…”

Section: The Non-human Primate As a Model Of Normative Agingmentioning

confidence: 99%

Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline

Kohama

Rosene

Sherman

2011

AGE

115

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The cognitive decline associated with normal aging was long believed to be due primarily to decreased synaptic density and neuron loss. Recent studies in both humans and non-human primates have challenged this idea, pointing instead to disturbances in white matter (WM) including myelin damage. Here, we review both cross-sectional and longitudinal studies in humans and non-human primates that collectively support the hypothesis that WM disturbances increase with age starting at middle age in humans, that these disturbances contribute to age-related cognitive decline, and that age-related WM changes may occur as a result of free radical damage, degenerative changes in cells in the oligodendrocyte lineage, and changes in microenvironments within WM.

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Section: The Non-human Primate As a Model Of Normative Agingmentioning

confidence: 99%

Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline

Kohama

Rosene

Sherman

2011

AGE

115

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“…An assumption-based study reported an age-related neuron loss in the CA1 region [9], whereas another nonstereological study showed no significant difference in the CA1 region or the subiculum [52]. However, one report that used a stereological approach showed no decrease in CA1 neuronal number, but a decreasing trend in the subiculum [65].…”

Section: Introductionmentioning

confidence: 99%

Preservation of hippocampal neuron numbers in aged rhesus monkeys

Keuker

Luiten

Fuchs

2003

Neurobiology of Aging

122

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Preservation of hippocampal neuron numbers in aged rhesus monkeys Keuker, J.I.H.; Luiten, P.G.M.; Fuchs, E. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. AbstractTo investigate whether or not aging of nonhuman primates is accompanied by a region-specific neuron loss in the hippocampal formation, we used the optical fractionator technique to obtain stereological estimates of unilateral neuron numbers of the hippocampi of eight young (0-4 years) and five aged (18-31 years) male rhesus monkeys (Macaca mulatta). Our results show a preservation of neurons (mean × 10 3 ± S.D. × 10 3 ) in the subiculum (young = 588 ± 124, aged = 612 ± 207), CA1 (young = 1051 ± 249, aged = 1318 ± 311), CA2 (young = 100 ± 18, aged = 113 ± 12), CA3 (young = 478 ± 125, aged = 509 ± 139), hilus (young = 337 ± 115, aged = 394 ± 90), and dentate gyrus (young = 5550 ± 1725, aged = 7799 ± 2087) of the hippocampal formation. These results confirm a previous stereological study in rhesus monkeys, but are in conflict with data for humans, showing age-dependent region-specific alterations in the hippocampal formation.

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“…They therefore concluded that there is neuronal loss from this cortex with age. Sub-sequently, the gyri bordering the principal sulcus in the frontal lobe were examined (Brizzee et al, 1980) and it was also concluded that neurons are lost from this portion of the cortex with age. From their analysis of the data, Coleman and Flood (1987) calculated that the reported neuronal loss amounted to as much as 20%.…”

mentioning

confidence: 99%

“…However, as with the human studies, the first accounts of the effect of aging on the cerebral hemispheres of monkeys also concluded that aging brings about a loss of neurons. Thus, Brizzee and his colleagues (Brizzee, 1973;Brizzee et al, 1975Brizzee et al, , 1980 examined the sensorimotor cortex from rhesus monkeys 4-6 years of age and compared it with that of 18-to 20-year-old monkeys. They recorded no age-associated change in the thickness of the sensorimotor cortex, but found a significant decrease in the packing density of small granular neurons, presumably at the level of layer IV.…”

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confidence: 99%

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Feature article: are neurons lost from the primate cerebral cortex during normal aging?

et al. 1998

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Localization of cellular changes within multimodal sensory regions in aged monkey brain: Possible implications for age-related cognitive loss☆

Cited by 93 publications

References 25 publications

Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline

Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline

Preservation of hippocampal neuron numbers in aged rhesus monkeys

Feature article: are neurons lost from the primate cerebral cortex during normal aging?

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