Localization of breakpoints in the karyotype of workers professionally exposed to benzene

The Nature of Chromosomal Aberrations Detected in Humans Exposed to Benzene

“…Increased structural changes in general have been detected in benzene-exposed workers (Damrau et al, 1986;Gao et al, 1994;Gundy, 1989;Khan and Khan, 1973;Tompa et al, 1994), with much larger increases reported among a group of subjects with longer exposure periods (Khan and Khan, 1973). Gaps and breaks were the types of structural CA most frequently increased in exposed workers (Fredga et al, 1979;FunesCravioto et al, 1977;Hartwich and Schwanitz, 1972;Jablonická et al, 1987;Major et al, 1994;Picciano, 1979;Sarto et al, 1984;Sasiadek, 1984;Sasiadek, 1992;Sasiadek and Jagielski, 1990;Sasiadek et al, 1989;Tunca and Egeli, 1994;Tunca and Egeli, 1996;Werner, 1986). In Sasiadek's series of studies from 1989 to 1992, higher than expected levels of breakage were located on chromosomes 2, 4, 7, and 9 (Sasiadek, 1992;Sasiadek and Jagielski, 1990;Sasiadek et al, 1989).…”

“…Gaps and breaks were the types of structural CA most frequently increased in exposed workers (Fredga et al, 1979;FunesCravioto et al, 1977;Hartwich and Schwanitz, 1972;Jablonická et al, 1987;Major et al, 1994;Picciano, 1979;Sarto et al, 1984;Sasiadek, 1984;Sasiadek, 1992;Sasiadek and Jagielski, 1990;Sasiadek et al, 1989;Tunca and Egeli, 1994;Tunca and Egeli, 1996;Werner, 1986). In Sasiadek's series of studies from 1989 to 1992, higher than expected levels of breakage were located on chromosomes 2, 4, 7, and 9 (Sasiadek, 1992;Sasiadek and Jagielski, 1990;Sasiadek et al, 1989). Increased rates of dicentric chromosomes were found in two recent reports (BogadiSare et al, 1997; Karacic et al, 1995).…”

Biomarkers of leukemia risk: benzene as a model.

“…An increased GPA mutation frequency has been found in children with leukemia and in people exposed to radiation and leukemogenic anticancer drugs (72). An increased level of gene-duplicating mutations in GPA has also been found in benzene-exposed workers (73 (84)(85)(86)(87). We are currently investigating the utility of these data in improving the risk assessment for benzene.…”

“…The incidence of leukemia grew steeply between 1900 and 1940 (11), and in Denmark increased 3-fold between 1943 and 1977, primarily because of increases in AML (12). Between 1969 and 1977, AML also increased 20% in 85 …”

Short Communication Genotoxic effects caused by indoor exposure to petroleum derivatives in a fuel quality control laboratory

“…Benzene is a genotoxic agent that shows clastogenic and carcinogenic properties, due to benzoquinone, one of its main metabolites, which commonly causes DNA breaks, chromosomal damage and sister chromatid exchanges (Dean, 1985;Sasiadek et al, 1989). Tunka and Egeli (1996) reported an increased frequency of chromosomal aberrations in 58 shoe workers, which was attributed to the high content of benzene and hexane in the glues.…”