Localization of bombesin-, neuropeptide Y-, enkephalin-and tyrosine hydroxylase-like immunoreactivities in rat coeliac-superior mesenteric ganglion

Järvi, Riitta

doi:10.1007/bf00500923

Cited by 18 publications

(7 citation statements)

References 24 publications

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“…It is well known that the coeliac ganglion-mesenteric complex is also innervated by fibres of an adrenergic nature that come from other preaortic ganglia, and that it exhibits α and β adrenergic receptors [24,25]. The presence of such receptors in coeliac ganglion was demonstrated physiologically in adult rats [8,26].…”

Section: Discussionmentioning

confidence: 99%

Ganglionic Adrenergic Action Modulates Ovarian Steroids and Nitric Oxide in Prepubertal Rat

et al. 2006

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Abstract. Both peripheral innervation and nitric oxide (NO) participate in ovarian steroidogenesis. The purpose of this work was to analyse the ganglionic adrenergic influence on the ovarian release of steroids and NO and the possible steroids/ NO relationship. The experiments were carried out in the ex vivo coeliac ganglion-superior ovarian nerve (SON)-ovary system of prepubertal rats. The coeliac ganglion-SON-ovary system was incubated in Krebs Ringer-bicarbonate buffer in presence of adrenergic agents in the ganglionic compartment. The accumulation of progesterone, androstenedione, oestradiol and NO in the ovarian incubation liquid was measured. Norepinephrine in coeliac ganglion inhibited the liberation of progesterone and increased androstenedione, oestradiol and NO in ovary. The addition of α and β adrenergic antagonists also showed different responses in the liberation of the substances mentioned before, which, from a physiological point of view, reveals the presence of adrenergic receptors in coeliac ganglion. In relation to propranolol, it does not revert the effect of noradrenaline on the liberation of progesterone, which leads us to think that it might also have a "per se" effect on the ganglion, responsible for the ovarian response observed for progesterone. Finally, we can conclude that the ganglionic adrenergic action via SON participates on the regulation of the prepubertal ovary in one of two ways: either increasing the NO, a gaseous neurotransmitter with cytostatic characteristics, to favour the immature follicles to remain dormant or increasing the liberation of androstenedione and oestradiol, the steroids necessary for the beginning of the near first estral cycle. AT present, there is clear evidence that ovarian steroidogenesis, besides being regulated by the classic hypothalamo-hypophyseal-ovarian axis, is influenced by the neural pathway. The main neural information reaches the ovaries by the hilium via the superior ovarian nerve and ovarian plexus [1,2]. Hirshfield [3] confirmed that the first follicles to start growing are those assembled near the ovarian hilium, the first region in the ovaries of the rat to be innervated during its fetoneonatal life [4]. The sympathetic innervation terminals are closely related to the steroidogenic ovarian cells [5], and peptidergic and catecholaminergic neurotransmitters, mainly norepinephrine [6][7][8], are released from the superior ovarian nerve (SON) to the ovary. Both peptides and norepinephrine act via adenylate cyclase coupled receptors that are present in the ovary at the beginning of the folliculogenesis [9,10]. Several experimental designs have been used to investigate the role of innervation in the control of the ovarian function of prepubertal rat. In this respect, it has been reported in ovarian cell culture that the effect of adrenergic agents depends on the number of betareceptor sites present in the ovaries of pre and peripubertal rats [11].Experiments carried out by our group have shown that the bilateral transection of the neonatal SON ...

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Section: Discussionmentioning

confidence: 99%

Ganglionic Adrenergic Action Modulates Ovarian Steroids and Nitric Oxide in Prepubertal Rat

et al. 2006

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“…Bars 250 nm Fig. 2b,c;Lindh et al 1988;Elfvin et al 1989;Gibbins et al 2003a), whereas in rats and mice, they are most easily recognised by their immunoreactivity to bombesin/gastrinreleasing peptide (Järvi 1989).…”

Section: Neuropeptides and Schwann Cellsmentioning

confidence: 96%

“…Prior to these studies, most of the information on the structure of enteric synapses came from ultrastructural analyses (e.g. see Gabella 1976Gabella , 1979Llewellyn-Smith et al 1981, 1989 showing that synapses within the enteric ganglia have a typical morphological appearance but that many boutons closely appose the somata of enteric neurons without obvious synaptic specialisations (Wilson et al 1981a,b;Li and Furness 2000). Subsequent ultrastructural immunohistochemistry has revealed that some types of enteric neurons form interconnected chains, within which most morphologically defined synapses are of a similar type (e.g.…”

Section: Enteric Ganglia -Complex Local Circuitsmentioning

confidence: 99%

Structure of peripheral synapses: autonomic ganglia

Gibbins

Morris

2006

Cell Tissue Res

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Final motor neurons in sympathetic and parasympathetic ganglia receive synaptic inputs from preganglionic neurons. Quantitative ultrastructural analyses have shown that the spatial distribution of these synapses is mostly sparse and random. Typically, only about 1%-2% of the neuronal surface is covered with synapses, with the rest of the neuronal surface being closely enclosed by Schwann cell processes. The number of synaptic inputs is correlated with the dendritic complexity of the target neuron, and the total number of synaptic contacts is related to the surface area of the post-synaptic neuron. Overall, most neurons receive fewer than 150 synaptic contacts, with individual preganglionic inputs providing between 10 and 50 synaptic contacts. This variation is probably one determinant of synaptic strength in autonomic ganglia. Many neurons in prevertebral sympathetic ganglia receive additional convergent synaptic inputs from intestinofugal neurons located in the enteric plexuses. The neurons support these additional inputs via larger dendritic arborisations together with a higher overall synaptic density. There is considerable neurochemical heterogeneity in presynaptic boutons. Some synapses apparently lack most of the proteins normally required for fast transmitter release and probably do not take part in conventional ganglionic transmission. Furthermore, most preganglionic boutons in the ganglionic neuropil do not form direct synaptic contacts with any neurons. Nevertheless, these boutons may well contribute to slow transmission processes that need not require conventional synaptic structures.

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“…The superior mesenteric ganglion is constituted by specific structures responding to the cholinergic stimulus such as the nicotinic and muscarinic receptors in the ganglionic neurons called principal neurons [5] and the muscarinic receptors present in the interneurons, such as the small intensely fluorescent (SIF) cells, and peptidergic cells [6]. Recent studies have shown that the superior mesenteric ganglion, through the ONP, participates not only in the regulation of the blood flow [7,8] but also in the ovary physiology [9].…”

Section: Introductionmentioning

confidence: 99%

Involvement of ganglionic cholinergic receptors on the steroidogenesis in the luteal phase in rat

Orozco

Sosa

Delgado

et al. 2010

The Journal of Steroid Biochemistry and Molecular Biology

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Localization of bombesin-, neuropeptide Y-, enkephalin-and tyrosine hydroxylase-like immunoreactivities in rat coeliac-superior mesenteric ganglion

Cited by 18 publications

References 24 publications

Ganglionic Adrenergic Action Modulates Ovarian Steroids and Nitric Oxide in Prepubertal Rat

Ganglionic Adrenergic Action Modulates Ovarian Steroids and Nitric Oxide in Prepubertal Rat

Structure of peripheral synapses: autonomic ganglia

Involvement of ganglionic cholinergic receptors on the steroidogenesis in the luteal phase in rat

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