Localization of a novel tumor suppressor gene associated with human oral cancer on chromosome 4q25

Functional evidence for a squamous cell carcinoma mortality gene(s) on human chromosome 4

“…Immortality is known to be an early event in multistage oral cancer, detectable at the dysplasia stage (McGregor et al, 1997), and comparative genomic hybridization has shown that a similar fraction of these lesions show a loss of chromosome 4q. Moreover, LOH has been reported within our candidate region at higher than background frequencies in squamous cell carcinoma of the head and neck (Pershouse et al, 1997;Shah et al, 2000;Wang et al, 1999). There is also strong evidence to link a 24 Mb region, spanning our region, with Huriez syndrome (MIM 181600), a heritable skin disorder which can predispose to squamous cell carcinoma of the skin and perhaps other tissues .…”

PRDM5 is silenced in human cancers and has growth suppressive activities

“…This gene maps to chromosome 4q25-q26. This region is commonly deleted in human breast cancer (Tirkkonen et al, 1997;Schwendel et al, 1998), ovarian cancer (Sonoda et al, 1997), lung cancer (Shivapurkar et al, 1999), hepatoma (Chou et al, 1998;Piao et al, 1998), cervical cancer (Mitra et al, 1994), head and neck squamous cell carcinoma (Pershouse et al, 1997), colon cancer (Arribas et al, 1999), and oral cancer (Wang et al, 1999). A candidate for the iris hypoplasia locus also maps on 4q25 (Heon et al, 1995).…”

The c-Jun NH2-terminal kinase3 (JNK3) gene: genomic structure, chromosomal assignment, and loss of expression in brain tumors

“…Shoko Yoshida · Koichi Fukino · Haruhito Harada Hisaki Nagai · Issei Imoto · Johji Inazawa Hiroshi Takahashi · Akira Teramoto · Mitsuru Emi (Simons et al 1999), esophageal adenocarcinomas (Rumpel et al 1999), and oral squamous cell carcinomas (Wang et al 1999); we ourselves have defined a 1-cM region at chromosome 4q21-22 that is commonly deleted in hepatocellular carcinomas (Bando et al 1999).…”