Localization of 14C-pancuronium by histo- and wholebody-autoradiography in normal and pregnant mice

Waser, Peter G.

doi:10.1007/bf00500805

Cited by 35 publications

(15 citation statements)

References 9 publications

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“…The study of drug disposition and metabolism is of considerable value, not only in understanding drug action in clinical practice, but also in defining those physicochemical properties which are important for the design of new drugs. Renal elimination of pancuronium appears to be the major excretory pathway in mice (WASER 1973), rats (SHINDO et al 1974, dogs (VAN DER VEEN 1971) and men (ACOSTON et al 1973b. TANAKA et al 1974, BUZELLO 1975.…”

Section: Discussionmentioning

confidence: 99%

“…The present studies were designed to determine the rate and extent of the hepatic uptake of the two newer compounds. I n addition to the earlier findings with pancuronium, our interest was stimulated by HUGHES ' (1972) report that, besides the acid mucopolysaccharides of the connective tissue (CHAGAS 1962, WASER & LUTHI 1968, ASGHAR & ROTH 1971, WASER 1973, the liver also may play an important role in the early removal of the…”

mentioning

confidence: 95%

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The Relationship between Disposition and Duration of Action of a Congeneric Series of Steroidal Neuromuscular Blocking Agents

Ágoston

Crul

Kersten

et al. 1977

Acta Anaesthesiol Scand

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The renal and hepatic elimination and biotransformation, as well as the relation between disposition and duration of action of pancuronium and two of its analogues, dacuronium and ORG.6368, have been investigated in the cat. In pharmacokinetic studies, appreciable amounts of the latter two compounds were found in the urine, bile and liver 8 h after their intravenous administration. Various proportions of the injected dose of the respective drugs were metabolized. In another series of experiments it was shown that the early hepatic uptake (during the first 3 min after the injection) of ORG.6368 was significantly greater than that of dacuronium and pancuronium. The intensity and duration of action of the neuromuscular blocking effect of the three compounds were studied after intravenous and "close" intraarterial injection. On the basis of these pharmacokinetic and neuromuscular studies, it was concluded that the short duration of action of ORG.6368 is due primarily to its early hepatic uptake. The possibility cannot be excluded, however, that differences in the kinetics of the drug action of ORG.6368 and the other two compounds also contributed significantly to the differences seen in the duration of action of these compounds.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 95%

The Relationship between Disposition and Duration of Action of a Congeneric Series of Steroidal Neuromuscular Blocking Agents

Ágoston

Crul

Kersten

et al. 1977

Acta Anaesthesiol Scand

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“…Albumin is quantitatively the most important plasma protein responsible for drug binding, but many drugs, especially basic drugs, may be bound to other plasma proteins as well (Ghoneim and Pandya, 1975). The literature on the extent of plasma protein binding of pancuronium is conflicting; Waser (1973), reported 20% binding for pancuronium in man and Thompson (1976) reported strong binding to gamma-globulin and moderate binding to albumin. Nevertheless, a decrease in plasma protein binding in patients with extrahepatic cholestasis may be one of the factors leading to the enlarged volume of distribution.…”

Section: Discussionmentioning

confidence: 99%

Hepatic and Renal Disposition of Pancuronium and Gallamine in Patients With Extrahepatic Cholestasis

Westra

Vermeer

Lange

et al. 1981

British Journal of Anaesthesia

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SUMMARYThe plasma clearance of pancuronium in patients with extrahepatic cholestasis was 16% lower than in a control group (1.47 ±0.11 mlmin"'kg" ' v. 1.76±0.21 mlmin"'kg"'), but the difference was not significant. A significant increase in the elimination half-life T± of pancuronium (from 141 to 224 min) and a significant increase in the volume of the peripheral compartment ( V 2 ) was found in patients with extrahepatic cholestasis when compared with control patients. There was a significantly lower cumulative biliary excretion of pancuronium (0.3±0.3% v. 10.9±3.2% in the controls) during the 48-h period of observation. The biotransformation and cumulative urinary excretion patterns of pancuronium revealed no significant differences between the two groups of patients. The increase of 7* + pancuronium in patients with extrahepatic cholestasis was mainly a consequence of the increase in the volume of distribution. No significant differences in the plasma clearance, 7*/ or in the volume of distribution were observed with gallnminr in the patients with extrahepatic cholestasis when compared with the control group. The cumulative urinary excretion of gallamine during 48 h in both groups of patients was approximately 100%. We concluded that in patients with cholestasis and normal glomerular nitration, gallamine is probably more reliable than pancuronium for neuromuscular blockade.

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“…The cationic binding properties of mucopolysaccharides (Laurent 1972) are supposed to be the factor behind the accumulation of these compounds in connective tissue (Waser 1973;Larsson et al 1978;Oskarsson and Tj~ilve 1979).…”

Section: Fetal L I V E Rmentioning

confidence: 97%

Selective binding of aldrin and dieldrin in cartilage

Brandt

Högman

1980

Arch Toxicol

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Localization of 14C-pancuronium by histo- and wholebody-autoradiography in normal and pregnant mice

Cited by 35 publications

References 9 publications

The Relationship between Disposition and Duration of Action of a Congeneric Series of Steroidal Neuromuscular Blocking Agents

The Relationship between Disposition and Duration of Action of a Congeneric Series of Steroidal Neuromuscular Blocking Agents

Hepatic and Renal Disposition of Pancuronium and Gallamine in Patients With Extrahepatic Cholestasis

Selective binding of aldrin and dieldrin in cartilage

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