Localization Methods for Excisional Biopsy in Women With Nonpalpable Mammographic Abnormalities

Rodhouse, Christine; Soliman, Iman; Cruse, Mariah; Kastrenakes, Joseph; Augustine, C.J.; Ludy, Alexis; Reintgen, Eric; Hoadley, A. E.; Desai, Divya; Nguyen, Minh; Reintgen, Douglas S.

doi:10.1016/j.clbc.2016.10.007

Cited by 5 publications

(2 citation statements)

References 3 publications

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“…In people, infection rate has been reported to range from 0 to 1% in patients where the guide wire was placed the day before the surgery and in patients that were moved from the radiological room (where the wire-guided was placed) to the operating room [20,21]. Since infections associated with wire-guided placement seemed infrequent in people, we could speculate that also in dogs moved from ultrasonography to the operating room, the risk of infection is low.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound-Guided Hook-Wire Localization for Surgical Excision of Non-Palpable Superficial Inguinal Lymph Nodes in Dogs: A Pilot Study

Pierini

Marchetti

Rossanese

et al. 2020

Animals

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The evaluation of loco-regional lymph nodes (LN) plays an important prognostic role and assists the clinical decision making in canine cancer patients. Excision of non-palpable LN can be challenging. The aim of the study was to evaluate surgical time, successful excision rate and surgical complications associated with the use of an ultrasound-guided hook-wire (UGHW) LN localization method for non-palpable superficial inguinal LN (SILN) in dogs. Dogs that presented for excision of non-palpable SILN, performed with the aid of an UGHW placement, were enrolled. Information including signalment, SILN width, UGHW placement and surgical procedure time, hook-wire position, successful excision and intra- and post-operative complications were reviewed. Seventeen dogs were enrolled. Median LN width was 3 mm (range 2–11). Median time of preoperative UGHW placement and surgical LN excision was 8 min and 15 min, respectively. Successful SILN excision was achieved in all cases. Two minor intra-operative (hook migration and wire fragmentation) and one minor post-operative complications (seroma) were observed. No major intraoperative or post-operative complications occurred. The UGHW LN localization method is safe and effective and may allow a high rate of successful SILN excisions in dogs. This method has the potential to facilitate LN excision for other superficial LN locations.

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Section: Discussionmentioning

confidence: 99%

Ultrasound-Guided Hook-Wire Localization for Surgical Excision of Non-Palpable Superficial Inguinal Lymph Nodes in Dogs: A Pilot Study

Pierini

Marchetti

Rossanese

et al. 2020

Animals

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“…Radical resection of all malignant tumor tissue remains the determined and standard method to remedy the cancerous lesion . To ensure precise excision, the nonpalpable tumor is labeled prior to surgery with a guidewire guided by ultrasound , or stereographic mammogram. , However, the wire localization could be an obstacle in the surgical process; the protruding wires can be nettlesome for patients, and moreover, the risk of displacement may lead to the failure of localization. Furthermore, this interventional operation is complicated and inefficient …”

Section: Introductionmentioning

confidence: 99%

Intraoperative Identification and Guidance of Breast Cancer Microfoci Using Ultrasound and Near-Infrared Fluorescence Dual-Modality Imaging

Lin

Zhang

Wang

et al. 2019

ACS Appl. Bio Mater.

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The traditional method of labeling the nonpalpable breast cancer is placing a guidewire or metal marker guided by ultrasound or stereographic mammogram prior to surgery. However, the wire localization has a risk of displacement and could be an obstacle in the surgical course. To avoid these issues, we tried to combine the near-infrared (NIR) fluorescence dye dioctadecyltetramethyl indotricarbocyanine iodide (DiR) and microbubbles (MBs) to realize the dual-modality imaging for breast cancer microfoci intraoperative identification and guidance as a more efficient workflow. First, 24 mice were divided into three groups, injected with DiR nanoparticles (NPs), DiR MBs, and DiR MBs + ultrasound (US), and then, in vivo and ex vivo NIR fluorescence imaging was conducted. The distinction of fluorescence imaging intensity at the tumor site among the three groups was statistically significant (P < 0.001). Group 3 (DiR MBs + US) exhibited the highest fluorescence imaging intensity; the distinctions between group 3 and group 1 (DiR NPs) and group 3 and group 2 (DiR MBs) were both statistically significant (P = 0.001, P = 0.003), while the distinction between group 1 and group 2 was not statistically significant (P = 1.0). The results above validated the advantage of fluorescence imaging by using ultrasound-targeted MB destruction. Second, two kinds of subcutaneous breast cancer mice models [4T1-luc(n = 5)/MCF-7(n = 3)] received tumor resection, and NIR fluorescence and bioluminescence images were obtained to detect tumor residuals. We found that the small residual tumor tissues, metastatic lymph nodes, and even the surrounding infiltrated tissue all can be indicated by the fluorescence imaging and verified with bioluminescence and histological examination. In addition, the residual tumor cells appeared as tumor recurrence 22 days post operation and was confirmed with contrast-enhanced ultrasound (CEUS) in vivo. Thereby, ultrasound-targeted DiR MB destruction and then conversion into DiR NPs was feasible for intraoperative identification and guidance of nonpalpable breast cancer foci.

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Current Trends in Localization Techniques for Non-palpable Breast Lesions: Making the Invisible Visible

Gunn

2017

Curr Breast Cancer Rep

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Localization Methods for Excisional Biopsy in Women With Nonpalpable Mammographic Abnormalities

Cited by 5 publications

References 3 publications

Ultrasound-Guided Hook-Wire Localization for Surgical Excision of Non-Palpable Superficial Inguinal Lymph Nodes in Dogs: A Pilot Study

Ultrasound-Guided Hook-Wire Localization for Surgical Excision of Non-Palpable Superficial Inguinal Lymph Nodes in Dogs: A Pilot Study

Intraoperative Identification and Guidance of Breast Cancer Microfoci Using Ultrasound and Near-Infrared Fluorescence Dual-Modality Imaging

Current Trends in Localization Techniques for Non-palpable Breast Lesions: Making the Invisible Visible

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