Localization and activity of tissue factor in human aortic atherosclerotic lesions

Circadian rhythm disorder of thrombosis and thrombolysis-related gene expression in apolipoprotein E knock-out mice

“…It is an important determinant of thrombogenicity which contributes to fibrin-rich thrombus formation after plaque disruption and contributes to the progression of atherosclerotic lesions (27)(28)(29). In the present study, we found a clear circadian rhythm in the hearts of all three groups.…”

Combination of a Brief Irrigation With Tissue Factor Pathway Inhibitor (TFPI) and Adenovirus-Mediated Local TFPI Gene Transfer Additively Reduces Neointima Formation in Balloon-Injured Rabbit Carotid Arteries

“…28,29 Conversely, Gallo et al 12 showed that thrombin activity in the plasma is detectable even 2 weeks after such injury. Hatakeyama et al 6 reported that the level of TF mRNA and its activity increased continuously in the neointima for 2 to 8 weeks after injury. In our study, an enhanced activity of TF persisted for Ն1 week after injury (Figure 2).…”

“…4 In atherosclerotic arteries, however, it is expressed ubiquitously in the plaques. 5,6 Furthermore, once injury occurs, TF becomes expressed within hours in almost all layers of the arterial wall. 7,8 Accumulating evidence suggests that TF may have a variety of actions in addition to initiating thrombin formation.…”

CRP regulates the expression and activity of tissue factor as well as tissue factor pathway inhibitor via NF‐κB and ERK 1/2 MAPK pathway

“…Tissue factor (TF), a critical initiator of blood clotting, is present in atherosclerotic plaque and triggers thrombosis after plaque rupture [12,13]. Several studies demonstrated that TF played a pivotal role in the pathophysiology of acute coronary syndrome (ACS) by inducing the intracoronary thrombosis following endothelial injury [14][15][16].…”