Localised deposition of amyloid in tears of the rotator cuff

Cole, Andrew S.; Cordiner-Lawrie, S.; Carr, Andrew; Athanasou, N A

doi:10.1302/0301-620x.83b4.0830561

Cited by 13 publications

(6 citation statements)

References 19 publications

(32 reference statements)

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“…However, the failure rate of these repairs is very high, estimated at up to 75 % (Galatz et al, 2004;Bishop et al, 2006;Huijsmans et al, 2007;Sugaya et al, 2007). A number of studies have shown that in late disease stages the tendon itself is extremely degenerate, with reduced cell numbers and poor matrix organisation (Cole et al, 2001;Benson et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

An electrospun polydioxanone patch for the localisation of biological therapies during tendon repair

Hakimi

Murphy²,

Stachewicz³

et al. 2012

eCM

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Rotator cuff tendon pathology is thought to account for 30-70 % of all shoulder pain. For cases that have failed conservative treatment, surgical re-attachment of the tendon to the bone with a non-absorbable suture is a common option. However, the failure rate of these repairs is high, estimated at up to 75 %. Studies have shown that in late disease stages the tendon itself is extremely degenerate, with reduced cell numbers and poor matrix organisation. Thus, it has been suggested that adding biological factors such as platelet rich plasma (PRP) and mesenchymal stem cells could improve healing. However, the articular capsule of the glenohumeral joint and the subacromial bursa are large spaces, and injecting beneficial factors into these sites does not ensure localisation to the area of tendon damage. Thus, the aim of this study was to develop a biocompatible patch for improving the healing rates of rotator cuff repairs. The patch will create a confinement around the repair area and will be used to guide injections to the vicinity of the surgical repair. Here, we characterised and tested a preliminary prototype of the patch utilising in vitro tools and primary tendon-derived cells, showing exceptional biocompatibility despite rapid degradation, improved cell attachment and that cells could migrate across the patch towards a chemoattractant. Finally, we showed the feasibility of detecting the patch using ultrasound and injecting liquid into the confinement ex vivo. There is a potential for using this scaffold in the surgical repair of interfaces such as the tendon insertion in the rotator cuff, in conjunction with beneficial factors.

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Section: Introductionmentioning

confidence: 99%

An electrospun polydioxanone patch for the localisation of biological therapies during tendon repair

Hakimi

Murphy²,

Stachewicz³

et al. 2012

eCM

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“…This reduced suture tissue‐holding strength in degenerative tears is most likely an irreversible structural change. Matthews et al [32] and Cole et al [8] demonstrated the marked degeneration, amyloid deposition and chondroid metaplasia in chronic tears. Additionally, torn and degenerated cuffs are much thinner than intact ones in the area where the sutures are placed.…”

Section: Discussionmentioning

confidence: 99%

Biomechanical evaluation of suture–tendon interface and tissue holding of three suture configurations in torn and degenerated versus intact human rotator cuffs

Wlk¹,

Abdelkafy

Hexel

et al. 2014

Knee Surg Sports Traumatol Arthrosc

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“…Sulfated GAG are associated with acute inflammation and new matrix formation, as well as amyloid production. A study conducted by Cole [42] demonstrated that supraspinatus chronic tears were characterized by 70% amyloid deposition on tendon context, unlike only 25% in patients suffering from acute traumatic injuries.…”

Section: Advances In Shoulder Surgerymentioning

confidence: 99%

The Role of Physical Medicine and Rehabilitation in Shoulder Disorders

Saggini¹,

Carmignano²,

Cosenza³

et al. 2018

Advances in Shoulder Surgery

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Shoulder pain is a common problem and it is responsible for a high proportion of patients presenting to general practice, causing work absenteeism and claims for sickness. A lot of factors and conditions can contribute to shoulder pain. The most prevalent cause is rotator cuff tendinitis; its relevance is correlated not only to its high prevalence rate but also to the fact that is disabling, causing high direct and indirect cost in industrialized country. Other causes of shoulder pain are shoulder impingement syndrome, calcific tendonitis, frozen shoulder, etc. In this context, physical medicine and rehabilitation plays a fundamental role. The conservative approach consists of several interventions. The aim is to decrease shoulder pain and to regain shoulder function, with the goal to reduce the degree of impingement, decreasing swelling and inflammation, and to minimize the risk of further injuries. The purpose of this chapter is to give an overview about shoulder disorders and their conservative treatment by means of physical therapy.

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Localised deposition of amyloid in tears of the rotator cuff

Cited by 13 publications

References 19 publications

An electrospun polydioxanone patch for the localisation of biological therapies during tendon repair

An electrospun polydioxanone patch for the localisation of biological therapies during tendon repair

Biomechanical evaluation of suture–tendon interface and tissue holding of three suture configurations in torn and degenerated versus intact human rotator cuffs

The Role of Physical Medicine and Rehabilitation in Shoulder Disorders

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