Localisation and stimulation of prostacyclin production in vascular cells

MacIntyre, D. Euan; Pearson, Jeremy D.; Gordon, John L.

doi:10.1038/271549a0

Cited by 360 publications

(90 citation statements)

References 23 publications

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“…As a matter of fact, endothelial cells used here were from bovine aorta and not from equine specific endothelial cells. However, a number of physiologic functions, such as the secretion of PGI 2 and ET-1 are shared by all endothelial cells [50,51]. As reported for the cow [22], these data show that LH did not cause a significant increase in angiogenic activity by any equine luteal structure evaluated.…”

Section: Discussionsupporting

confidence: 72%

Microvascularization and angiogenic activity of equine corpora lutea throughout the estrous cycle

Ferreira‐Dias¹,

Pinto‐Bravo²,

Mateus³

et al. 2006

Domestic Animal Endocrinology

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Corpus luteum growth and endocrine function are closely dependent on the formation of new capillaries. The objectives of this study were to evaluate (i) tissue growth and microvascular development in the equine cyclic luteal structures; (ii) in vitro angiogenic activity of luteal tissues in response to luteotrophic (LH, PGE 2 ) and luteolytic (PGF 2␣ ) hormones and (iii) to relate data to luteal endocrinological function. Our results show that microvascular density was increased in the early and mid luteal phase, followed by a fall in the late luteal phase and a further decrease in the corpus albicans. Hyperplasia of luteal tissue increased until the mid luteal phase and it was followed by tissue regression. Luteal explants were cultured with no hormone added, or with PGF 2␣ , LH, PGE 2 , LH + PGE 2 or LH + PGF 2␣ . Media conditioned by equine luteal tissue from different stages of the luteal phase were able to stimulate mitogenesis of bovine aortic endothelial cells (BAEC), suggesting the presence of angiogenic activity. No difference was observed among luteal structures on their mitogenic capacity, for any treatment used. Nevertheless, Late-CL conditioned-media with PGF 2␣ showed a significant decrease in BAEC proliferation (p < 0.05) and LH + PGF 2␣ a tendency to reduce mitogenesis. Thus, prostaglandin F 2␣ may play a role on vascular regression of the CL during the late luteal phase in the * Corresponding author. Tel.: +351 213652859; fax: +351 213652889. -mail address: gmlfdias@fmv.utl.pt (G. Ferreira-Dias Ferreira-Dias et al. / Domestic Animal Endocrinology 30 (2006) [247][248][249][250][251][252][253][254][255][256][257][258][259] mare. These data suggest that luteal angiogenesis and vascular regression in the mare are coordinated with the development of non-vascular tissue and might be regulated by many different factors. E

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Section: Discussionsupporting

confidence: 72%

Microvascularization and angiogenic activity of equine corpora lutea throughout the estrous cycle

Ferreira‐Dias¹,

Pinto‐Bravo²,

Mateus³

et al. 2006

Domestic Animal Endocrinology

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“…GCs block endothelial cell production and release of the vasodilators PGE 2 and PGI 2 in response to various stimuli. [28][29][30][31][32][33][34] Administration of GCs to thrombocytopenic rabbits results in a dose-dependent shortening of the bleeding time which may result from inhibition of endothelial PGI 2 production and consequent augmentation of platelet aggregation. 29 GCs also stimulate vascular endothelial cell synthesis of fibronectin matrix, which is capable of inducing platelet adhesion to the subendothelium by binding glycoprotein IIb/IIIa on platelet surface membranes.…”

Section: Discussionmentioning

confidence: 99%

Thrombotic microangiopathy following allogeneic bone marrow transplantation is associated with intensive graft-versus-host disease prophylaxis

Paquette

Tran

Landaw³

1998

Bone Marrow Transplant

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Summary:Thrombotic microangiopathy (TM), manifesting clinically as thrombotic thrombocytopenic purpura or hemolytic uremic syndrome, is an uncommon complication after bone marrow transplantation (BMT). A retrospective analysis of potential risk factors for TM following allogeneic BMT was performed. Clinical data were analyzed from seven patients diagnosed with severe TM and 409 patients who underwent BMT during the same time period and who survived for at least 100 days afterwards. Six of the seven patients with TM received intensive GVHD prophylaxis consisting of cyclosporine, methotrexate and glucocorticoids, whereas only 66 of the 409 patients without TM received this regimen (P Ͻ 0.001, Fisher's exact test). This regimen was administered to patients older than 40 years, or recipients of a mismatched or unrelated allograft. Univariate analysis also revealed an increased risk of TM associated with the use of an unrelated bone marrow donor (P = 0.02), but no significant association with patient age or gender, diagnosis, amount of prior chemotherapy, transplant conditioning regimen or severity of GVHD. A multivariate exact logistic regression analysis revealed that only the type of GVHD prophylaxis had a significant impact on the risk for TM. The combined use of cyclosporine, methotrexate and glucocorticoids as GVHD prophylaxis may predispose to the development of TM following BMT. Keywords: thrombotic thrombocytopenic purpura; hemolytic uremic syndrome; bone marrow transplantation; graftversus-host disease Thrombotic microangiopathy (TM) is a pathological process characterized by occlusion of the microvasculature by hyaline thrombi resulting in microangiopathic hemolytic anemia, thrombocytopenia and end organ dysfunction. Clinically, TM manifests as hemolytic uremic syndrome (HUS) when the renal vasculature is primarily affected, or as thrombotic thrombocytopenic purpura (TTP) when there is diffuse vascular involvement. The onset of TM has been associated with infection by a variety of bacterial or viral pathogens. 1 There is a well-documented association between infection with E. coli strain O157:H7 and the occurrence of HUS. 2,3 Individuals infected with the human immunodeficiency virus have an increased incidence of TTP. 4 TM also occurs in relation to pregnancy; TTP tends to occur in the ante-partum period while HUS is more frequent post-partum. 1 Administration of chemotherapy, especially mitomycin C, has been associated with the development of HUS. 5 These various etiologies are thought to share the ability to induce injury to the vascular endothelium. Plasma exchange is highly effective therapy for TTP; HUS may also respond to this therapy. 3,6 TM is an uncommon complication of allogeneic bone marrow transplantation (BMT). More than 63 cases of TM have been reported to occur in this setting. 7 The first case of TM following allogeneic BMT was observed during the earliest use of cyclosporine (CsA) prophylaxis for graftversus-host disease (GVHD). 8 Subsequently, the occurrence of TM was found to be signifi...

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“…Production of prostacyclin by cultured cells from vessel walls also shows that endothelial cells are the most active producers of prostacyclin (Weksler, Knapp & Jaffe, 1977; Maclntyre, Pearson & Gordon, 1978); moreover, this production persists after numerous subcultures in vitro (Christofinis, Moncada, Bunting & Vane, 1979).…”

Section: Generation By the Vessel Wallmentioning

confidence: 99%

Eighth Gaddum Memorial Lecture University of London Institute of Education December 1980: Biological Importance of Prostacyclin

Moncada¹

1982

British J Pharmacology

266

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Localisation and stimulation of prostacyclin production in vascular cells

Cited by 360 publications

References 23 publications

Microvascularization and angiogenic activity of equine corpora lutea throughout the estrous cycle

Microvascularization and angiogenic activity of equine corpora lutea throughout the estrous cycle

Thrombotic microangiopathy following allogeneic bone marrow transplantation is associated with intensive graft-versus-host disease prophylaxis

Eighth Gaddum Memorial Lecture University of London Institute of Education December 1980: Biological Importance of Prostacyclin

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