Local Zones of Endoplasmic Reticulum Complexity Confine Cargo in Neuronal Dendrites

Wang, Tingting; Hanus, Cyril; Cui, Tao; Helton, Thomas D.; Bourne, Jennifer N.; Watson, Deborah; Harris, Kristen M.; Ehlers, Michael

doi:10.1016/j.cell.2011.11.056

Cited by 184 publications

(237 citation statements)

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“…Dendritic development involves dynamic rearrangements of the actin and microtubule cytoskeleton, which provide the framework necessary for directional intracellular motility. Local control of ER complexity has also been shown to spatially control secretory trafficking within elaborate dendritic arbors by acting as focal points of ER export and sites of new dendritic branch formation (Cui-Wang et al, 2012). In addition, the ER-Golgi bi-directional secretory trafficking network interacts closely with the actin cytoskeleton.…”

Section: Discussionmentioning

confidence: 99%

“…Morphological changes that occur during neuronal differentiation, particularly dendritic branching, are highly dynamic involving cyto-architecture and signaling events that require the coordinated addition of membrane to particular regions. Given the extremely large areas and distances over which secreted molecules and membrane must be transported in neurons to promote growth, the secretory pathway has specialized functional significance in providing the major source of plasma membrane to promote dendritic growth and facilitate branching (Cui-Wang et al, 2012). Neurons have evolved a rather novel spatial organization of the endoplasmic reticulum (ER) and Golgi compared with non-neuronal cells: they have somatic and satellite dendritic ER and Golgi compartments known as ER or Golgi outposts (Aridor et al, 2004;Horton and Ehlers, 2003;Ye et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Cut via CrebA transcriptionally regulates the COPII secretory pathway to direct dendrite development inDrosophila

Iyer

Meduri

et al. 2013

Journal of Cell Science

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SummaryDendrite development is crucial in the formation of functional neural networks. Recent studies have provided insights into the involvement of secretory transport in dendritogenesis, raising the question of how the secretory pathway is controlled to direct dendritic elaboration. Here, we identify a functional link between transcriptional regulatory programs and the COPII secretory machinery in driving dendrite morphogenesis in Drosophila dendritic arborization (da) sensory neurons. MARCM analyses and gain-of-function studies reveal cell-autonomous requirements for the COPII coat protein Sec31 in mediating da neuron dendritic homeostasis. We demonstrate that the homeodomain protein Cut transcriptionally regulates Sec31 in addition to other components of COPII secretory transport, to promote dendrite elaboration, accompanied by increased satellite secretory endoplasmic reticulum (ER) and Golgi outposts primarily localized to dendritic branch points. We further establish a novel functional role for the transcription factor CrebA in regulating dendrite development and show that Cut initiates a gene expression cascade through CrebA that coordinately affects the COPII machinery to mediate dendritic morphology.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cut via CrebA transcriptionally regulates the COPII secretory pathway to direct dendrite development inDrosophila

Iyer

Meduri

et al. 2013

Journal of Cell Science

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“…A range of neuronal transmembrane proteins, including AMPARs, NMDARs and GABA B Rs, can be translated using both somatic and dendritically localised ribosome patterned rough ER. They then traffic from the ER using dendritic ER exit sites and utilise the somatic Golgi or dendritic Golgi outposts for mature glycosylation [48, [58][59][60][61][62]. Importantly, all of the secretory pathway machinery appears to be present in neurites as iGluRs can mature in isolated dendrites [63].…”

Section: Local Dendritic Translation and Secretory Pathway Traffickingmentioning

confidence: 99%

Exciting Times: New Advances Towards Understanding the Regulation and Roles of Kainate Receptors

et al. 2017

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Kainate receptors (KARs) are glutamate-gated ion channels that play fundamental roles in regulating neuronal excitability and network function in the brain. After being cloned in the 1990s, important progress has been made in understanding the mechanisms controlling the molecular and cellular properties of KARs, and the nature and extent of their regulation of wider neuronal activity. However, there have been significant recent advances towards understanding KAR trafficking through the secretory pathway, their precise synaptic positioning, and their roles in synaptic plasticity and disease. Here we provide an overview highlighting these new findings about the mechanisms controlling KARs and how KARs, in turn, regulate other proteins and pathways to influence synaptic function.

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“…Recent studies suggest that the dendritic endoplasmic reticulum (ER) might also play a role in the localization of essential proteins at branch points, highlighting an important role for protein kinase C (PKC) and the ER protein CLIMP-63 (also known as Ckap4) in spatially limiting AMPA receptors in response to type I metabotropic glutamate receptor (mGluR) signaling (Cui-Wang et al, 2012). Remarkably, local zones of ER complexity reside at branch points that work with these proteins to concentrate AMPA receptors.…”

Section: Motor Proteins and Microtubule Regulatorsmentioning

confidence: 99%

Cell-intrinsic drivers of dendrite morphogenesis

Puram

Bonni

2013

Development

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The proper formation and morphogenesis of dendrites is fundamental to the establishment of neural circuits in the brain. Following cell cycle exit and migration, neurons undergo organized stages of dendrite morphogenesis, which include dendritic arbor growth and elaboration followed by retraction and pruning. Although these developmental stages were characterized over a century ago, molecular regulators of dendrite morphogenesis have only recently been defined. In particular, studies in Drosophila and mammalian neurons have identified numerous cell-intrinsic drivers of dendrite morphogenesis that include transcriptional regulators, cytoskeletal and motor proteins, secretory and endocytic pathways, cell cycle-regulated ubiquitin ligases, and components of other signaling cascades. Here, we review cell-intrinsic drivers of dendrite patterning and discuss how the characterization of such crucial regulators advances our understanding of normal brain development and pathogenesis of diverse cognitive disorders. KEY WORDS: Cell-intrinsic driver, Dendrite development, Dendrite morphogenesis, Dendrite patterning, Transcription factor, Ubiquitin ligases IntroductionWith their tremendous complexity and diversity, dendrites are one of nature's architectural masterpieces. More than a century ago, Ramón y Cajal proposed an important role for dendrites (referred to at that time as protoplasmic processes) as specialized morphological structures that receive neuronal input (Ramón y Cajal, 1995). Further studies using a variety of neuronal cell types (see Glossary, Box 1) have vastly improved our understanding of dendrite development (Scott and Luo, 2001;Grueber and Jan, 2004). The development of new approaches for studying dendrite morphogenesis (see Box 2) has led to the view that axons and dendrites work in concert to define neuronal connectivity. A key concept that has emerged from such functional studies is that the particular shapes of dendrites are intimately tied to the proper wiring of neuronal circuits and their function (Häusser et al., 2000;Parrish et al., 2007b;Branco et al., 2010;Branco and Häusser, 2011;Gidon and Segev, 2012; Lavzin et al., 2012).Prior to the elaboration of dendrites, neurons undergo axodendritic polarization, whereby the morphologically and functionally distinct axonal and dendritic compartments (see Box 3) are specified. In most neurons, including retinal ganglion neurons, forebrain pyramidal neurons and cerebellar granule neurons, the generation of an axon precedes the development and elaboration of dendrites (Ramón y Cajal, 1995). Although individual neuronal cell Anterodorsal and lateral projection neurons (aPNs and lPNs). These neurons of the Drosophila antennal lobe are crucial for olfactory processing. They receive excitatory input from olfactory receptor neurons in glomeruli and transmit signals to the mushroom body and lateral horn. Cerebellar granule neurons. The most numerous neurons of the brain, these offer an ideal system for biochemical, morphological and physiological studi...

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Local Zones of Endoplasmic Reticulum Complexity Confine Cargo in Neuronal Dendrites

Cited by 184 publications

References 56 publications

Cut via CrebA transcriptionally regulates the COPII secretory pathway to direct dendrite development inDrosophila

Cut via CrebA transcriptionally regulates the COPII secretory pathway to direct dendrite development inDrosophila

Exciting Times: New Advances Towards Understanding the Regulation and Roles of Kainate Receptors

Cell-intrinsic drivers of dendrite morphogenesis

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