Local wound infiltration with a mixture of tramadol and bupivacaine versus bupivacaine alone in those undergoing lower abdominal surgery: Prospective cohort study, 2020

Abstract

Background: Postoperative pain can have immediate and long-term consequences, including poor outcomes and prolonged hospitalization. It can also lead to chronic pain if not treated. Wound site infiltration with local anesthetic agents provides desirable analgesia for postoperative pain relief. The purpose of this study was to compare the analgesic effectiveness of local wound infiltration with a mixture of bupivacaine and tramadol (BT) versus bupivacaine alone (BA) for postoperative analgesia. Method: A prospective cohort study design was employed on 120 patients who underwent elective lower abdominal surgery under general or spinal anesthesia and were selected by using a systematic random sampling technique. Patients were divided into two groups based on the anesthetist in charge of postoperative pain management. Patients who received BT at the end of surgery are called BT groups, and patients who received BA are called BA groups (control). Result: The median (interquartile range) of pain severity score was significantly lower in the BT group as compared to the BA group with a p-value of 0.001. And, the median time to first analgesic request in the BT group was significantly longer as compared to patients in the BA group, with a p-value of 0.001. Conclusion: Local wound infiltration with BT decreases the postoperative pain score, total analgesic consumption, and has a prolonged time to first analgesia request as compared to BA. Therefore, we recommend using a local wound infiltration with BT to be effective for postoperative analgesia in patients undergoing elective lower abdominal surgery under general or spinal anesthesia. Highlights

Analgesic Effectiveness of Wound Infiltration with Bupivacaine Versus a Mixture of Bupivacaine with Tramadol for Postoperative Pain Management Among Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia at Dilla University Referal Hospital, 2023: A Double-Blind Randomized Controlled Trial

“…The estimated postoperative pain-free period was comparable (P = 0.01) for the two groups. The rst rescue periods for both groups and the total amount of rescue analgesic required were comparable (P > 0.05) (31). The discrepancies may be due to the difference in the study population, sample size, and drug dosage used.…”

Effect of Intraligamentary Tramadol Hydrochloride on Anesthetic Success During Endodontic Management of Mandibular Molars: A Randomized Clinical Controlled Trial

“…It was reported that the addition of 100 mg tramadol to 0.25% bupivacaine fastens the onset and prolongs the duration, compared with 0.25% bupivacaine given alone ( 38 ). Similarly, local wound infiltration of bupivacaine-plus-tramadol was more effective than bupivacaine alone in decreasing postoperative pain during lower abdominal surgery ( 39 ). In dentistry, the local anesthetic efficacy of tramadol has been mainly evaluated during oral surgical procedures.…”