Local Use of Insulin in Wounds of Diabetic Patients

Martínez-Jiménez, Mario Aurelio; Aguilar-García, Jorge; Valdés‐Rodríguez, Rodrigo; Metlich-Medlich, Marco Antonio; Dietsch, Laura Judith Porro; Gaitan-Gaona, Francisco; Kolosovas-Machuca, Eleazar Samuel; González, Francisco; Sánchez-Aguilar, Jesús Martín

doi:10.1097/prs.0b013e3182a806f0

Cited by 45 publications

(24 citation statements)

References 17 publications

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“…The insulin liposomal formulation was added to chitosan gel that has a wound-healing activity. Our results were in accordance with several previous reports that have proven the efficacy of topical insulin in accelerating the healing process of skin burns, 20 acute and chronic wounds, 7,21 and diabetic foot 22 and pressure ulcers. 23 Our results could be attributed to the anabolic action of insulin as a growth factor in healing events.…”

Section: Discussionsupporting

confidence: 93%

“…were 45 (43-47.8) and 48 (41-50) for test and placebo groups, respectively, with a non-significant difference (P = .576). After 6 days, values were 13 (11)(12)(13)(14) and 21 (20)(21)(22)(23)(24)(25)(26)(27)(28) for test and placebo groups, respectively. The test group showed a statistically significantly lower median score than placebo (P < .001) ( Table 2).…”

Section: The Median and Iqr Values For Ohip-14 Scores At Base Linementioning

confidence: 99%

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Topical insulin‐liposomal formulation in management of recurrent aphthous ulcers: A randomized placebo‐controlled trial

El-Wakeel

Dawoud

2019

J of Invest & Clin Dent

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Aim To evaluate the effectiveness of topical insulin‐liposomal gel in aphthous ulcer treatment. Methods 80 participants with minor aphthous ulcers were randomly divided to receive either topical insulin‐liposomal gel or placebo gel (once daily) for 6 days. Assessment of outcomes included visual analog scale (VAS) for pain (primary outcome), and secondary outcomes included ulcer duration and impact of treatment on quality of life using the Oral Health Impact Profile 14 (OHIP‐14). Testing of the outcomes was carried out at 1, 2, 3, 4 and 6 days after treatment for VAS and at 6 days for OHIP‐14. Results For pain scores, the test group showed a significant decrease by time, this was evident from day 1 (P < .001); at day 3, median and interquartile range (IQR) values were 0 (0‐1). For the placebo group, a non‐significant change by time was reported between baseline and day 1; at day 3, the median value was 7 (IQR, 7‐9). The test group showed significantly lower mean duration than the placebo group (P < .001). OHIP‐14 scores after 6 days showed that the test group had a significantly lower score than placebo (P < .001). Conclusions Topical insulin‐liposomal formulation showed marked effectiveness in management of aphthous ulcers.

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Section: Discussionsupporting

confidence: 93%

Section: The Median and Iqr Values For Ohip-14 Scores At Base Linementioning

confidence: 99%

Topical insulin‐liposomal formulation in management of recurrent aphthous ulcers: A randomized placebo‐controlled trial

El-Wakeel

Dawoud

2019

J of Invest & Clin Dent

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“…The T sk obtained by IRT during different periods of the day show variations in all the regions, which corroborates other studies that also found variations in T rectal (Dijk et al, 2012;Monk et al, 1995;Thomas et al, 2004), T axillar (Edwards et al, 2002;Thomas et al, 2004), T gastrointestinal (Edwards et al, 2002), T oral (Edwards et al, 2008) and T sk (Pronina and Rybakov, 2011) during the day characterized by circadian rhythms. Unlike most of the aforementioned studies that monitored only one site or variable (i.e.…”

Section: Discussionsupporting

confidence: 90%

“…In participants with a normal lifestyle, the Tc has higher values between 14 h and 20 h, the acrophase around 17 h, and the bathyphase at 5 h (Krauchi and Wirz-Justice, 1994). Rectal temperature (T rectal ) (Dijk et al, 2012;Monk et al, 1995;Thomas et al, 2004), axillary temperature (T axillar ) (Edwards et al, 2002;Thomas et al, 2004), gastrointestinal temperature (T gastrointestinal ) (Edwards et al, 2002), oral ⁎ Correspondence to: Carlos Magno Amaral Costa, Rua Alcobaça, 1500, Bloco 5, 504, CEP: 31255-210, Belo Horizonte, MG, Brazil. E-mail address: amaral.adjunto@gmail.com (C.M.A.…”

Section: Introductionmentioning

confidence: 99%

Daily rhythm of skin temperature of women evaluated by infrared thermal imaging

Costa

Moreira

Quintana

et al. 2018

Journal of Thermal Biology

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It is well known that skin temperature varies due to circadian rhythm. Although there is information available for men, little is known about women's circadian rhythm in the analysis of skin temperature (Tsk) using infrared thermography. The objective of this study is to identify Tsk variations on different body regions in women through infrared thermography during the day. The sample consisted of 20 female (mean age of 20.5 ± 1.3 years, body weight of 62.2 ± 9.2kg and height of 165.0 ± 4.7cm). Oneway ANOVA for repeated measures, and Cosinor analysis was used to determine the MESOR, amplitude and acrophase of Tsk. The regions of the forearm, upper arm and anterior and posterior legs in the lower limbs, as well as the chest and scapulae in the upper limbs showed higher variability throughout the day. In general, distal regions had lower values compared with the central regions, and the pectoral region had the lowest standard deviation values. Tsk of the analyzed regions at different times show significant differences between periods of the day in young active women, showing the minimum absolute values for both Tsk in the early morning. These results highlight the need to consider the time of day when analyzing women's skin temperature. Future studies should report the time of day when the images were collected, as well as consider the circadian rhythm when making comparisons.

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“…Martinez et al (2013) investigated the effect of local insulin administration in 8 diabetic patients with acute and chronic diabetic wounds. 39 Half of the wound surface in each patient was treated with insulin (10 U) daily for 14 days, whereas the other half was not treated with insulin. There were significant differences in the number of vessels, percentage of fibrosis, and mean temperature between the insulin-treated and placebo sides.…”

Section: Clinical Studiesmentioning

confidence: 99%

<p>Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences</p>

Wang

2020

DMSO

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Wound healing is a complex biological process that repairs damaged tissues and restores skin integrity. Insulin, a potent factor of wound healing, has been reported for nearly a century to induce rapid recovery of various wounds, as shown by numerous human and animal studies. Although many studies have addressed the healing effect of systemic insulin on burn wound, only few have investigated the efficacy of topical insulin. Thus, this study aimed to review evidence of the effects of topical insulin on wound healing, including on diabetic and non-diabetic wounds. The presented animal and clinical studies support that topical insulin improves wound healing through several mechanisms without causing side effects. Additionally, various wound dressings accelerate the wound healing with controlled and sustained delivery of bioactive insulin. Therefore, topical insulin has been appreciated in field of wound healing, and further studies are needed to improve our understanding of the role of insulin in the healing of various wounds.

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Local Use of Insulin in Wounds of Diabetic Patients

Abstract: Therapeutic, II.

Cited by 45 publications

References 17 publications

Topical insulin‐liposomal formulation in management of recurrent aphthous ulcers: A randomized placebo‐controlled trial

Topical insulin‐liposomal formulation in management of recurrent aphthous ulcers: A randomized placebo‐controlled trial

Daily rhythm of skin temperature of women evaluated by infrared thermal imaging

<p>Effects of Topical Insulin on Wound Healing: A Review of Animal and Human Evidences</p>

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