Local Usage of Nigella sativa Oil as an Innovative Method to Attenuate Primary Dysmenorrhea: A Randomized Double-blind Clinical Trial

Abstract

Objectives We sought to determine the effect of topical application of Nigella sativa (black seed) oil, on the primary dysmenorrhea intensity. Methods We conducted a randomized, double-blind clinical trial on 124 female students, 18–22 years old, living in the dormitories of Sabzevar Universities. After a primary assessment, participants were randomly divided into two groups. The first group rubbed two drops of N. sativa oil, and the second group rubbed liquid olive oil, as the placebo. Massage was performed on the fontanel lobe 3, at night, three days before menstruation, for eight consecutive days (about five days after menses). This procedure was repeated for three menstrual cycles. After three cycles, pain severity was measured by the visual analog scale. Data analysis was carried out using the Mann-Whitney U test and analysis of covariance (ANCOVA). Results This study was conducted on 124 female students. The mean age of students, mean age of first menarche, body mass index, and pain severity were not significantly different in the two groups ( p > 0.050). No adverse effects were observed during the study. The results of ANCOVA showed that pain intensity in N. sativa oil group was significantly decreased compared to that of the placebo group (0.6 score; p < 0.050). Conclusions N . sativa could be a promising, safe, and easily available analgesic supplement in women suffering from primary dysmenorrhea.

Nigella sativa and Thymoquinone: A Natural Blessing for Periodontal Therapy

“…The drug formulation and bioavailability of TQ is restricted by its hydrophobic characteristics [ 59 ]. Administration of TQ can occur through several routes, including systemic intraperitoneal, intravenous, oral subacute and sub-chronic administration, besides the localized drug delivery of TQ [ 6 , 60 , 61 ]. In the current investigation the reviewed in vivo studies reported the local periodontal application of 0.1–0.2% TQ gel [ 62 , 63 , 64 ] and similarly in the form of fabricated periodontal chips containing 2.5 mg of TQ [ 65 ].…”

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“…The volatile oil from Nigella seeds suppressed both spontaneous and oxytocin-induced contractions in the uterine smooth muscle of rats and guinea pigs 7 . N. sativa's analgesic effect has also been clinically demonstrated 8,9 . Except for depression and stomach bloating, Nigella sativa oil was found to diminish the intensity of all Premenstrual syndrome symptoms 10 and Huseini et al verified the analgesic effects of Nigella sativa on patients with cyclic mastalgia 11 .…”

Complementary therapies and factors related to dysmenorrhoea in adolescents: A bibliometric analysis

“…Female adolescents are populations that expe-rience various changes in hormonal, physical, cognitive and emotional maturity as well as social status in society. [1][2][3][4] This change can be identified from the responsibilities they will face in society and their new roles. 5 Physical changes are anoth-er issue that occurs in the adolescent population.…”